Connecting omics signatures and revealing biological mechanisms with iLINCSiLINCS로 omics 서명 연결 및 생물학적 메커니즘 공개Article Published on 2022-08-092022-09-11 Journal: Nature Communications [Category] 신약개발, 유전자 메커니즘, 임상, 치료법, 치료제, [키워드] analysis Analysis analytics bioinformatics Cancer cellular COVID 19 dataset disease facilitate iLINCS mechanism mechanism of action mTOR mTOR signaling perturbations platform programming resource transcriptomic utility Visualization web-based platform [DOI] 10.1038/s41467-022-32205-3 PMC 바로가기 [Article Type] Article
Network approaches for modeling the effect of drugs and diseases약물 및 질병의 영향 모델링을 위한 네트워크 접근 방식Review Published on 2022-07-182022-09-11 Journal: Briefings in Bioinformatics [Category] COVID19(2023년), SARS, 신약개발, [키워드] adverse effects Algorithm approach approach biological networks biological response Chronic diseases Compound computational method Computational methods COVID-19 disease disease modeling Diseases drug drug combination drug combinations drug target drug treatments drug’s MOA drugs explain FDA-approved drug generate IMPROVE in silico induce mechanism mechanism of action network network analysis network analysis. omics technologies Perturbation perturbations SARS-COV-2 infection SARS-CoV-2 infections Stage study drug Support targets therapeutic effect These data to define Treatment [DOI] 10.1093/bib/bbac229 PMC 바로가기 [Article Type] Review
Immune Cells Profiles In The Peripheral Blood Of Patients With Moderate To Severe COVID-19 And Healthy Subjects With and Without Vaccination With The Pfizer-BioNTech mRNA VaccinePfizer-BioNTech mRNA 백신 접종 여부에 관계없이 중등도에서 중증 COVID-19 환자 및 건강한 피험자의 말초혈 면역 세포 프로필Article Published on 2022-07-112022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 치료기술, [키워드] acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 adaptive analyzed B cell B cells Blood causative agent caused CD14 CD16 CD19 CD19+ CD3+ CD4+ CD4+ T cells CD4+ T lymphocyte CD56 CD56+ CD8+ T cell CD8+ T cells clinical manifestations coronavirus 2 coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient COVID-19 patients detectable determine dysregulated flow cytometry Frequency group healthy control healthy subject healthy subjects HLA-DR host response immune Immune cell immune cells immune response Inflammatory Kuwait lymphocyte Lymphocyte subset Lymphocyte subsets Lymphocytes moderate moderate to severe monocyte monocyte subsets Monocytes mRNA mRNA vaccine NK cell NK cells no symptom no symptoms percentage percentages peripheral Peripheral blood Perturbation perturbations Pfizer Pfizer-BioNTech profile profiles PROTECT required respiratory SARS-CoV-2 Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe disease significantly higher significantly lower subjects subset T cells T lymphocytes the patient three group three groups vaccination vaccination. was performed with COVID-19 [DOI] 10.3389/fimmu.2022.851765 PMC 바로가기 [Article Type] Article
A cautionary note on altered pace of aging in the COVID-19 era코로나19 시대 고령화 속도 변화에 대한 주의사항Article Published on 2022-07-012022-09-11 Journal: Forensic science international. Genetics [Category] COVID19(2023년), MERS, SARS, 바이오마커, 유전자 메커니즘, [키워드] accumulated acute respiratory syndrome Affect age aging all-cause mortality Alter Blood chronological age Clinical research CLOCK confounder Corona virus coronavirus disease Coronavirus disease 2019 COVID COVID-19 COVID-19 pandemic DNA methylation DNA methylation markers Effect Epigenetic Forensic Forensic age estimation heterogeneous nature Immune cell immune cells immune response individual individuals Interpretation joint life style management marker Modification modify molecular mortality risk pace pandemic pathogen Pathogens Pathologies pathology performed persistence Perturbation perturbations reliability Research respiratory risk SARS-CoV-2 SARS-CoV-2 pandemic scar Severe acute respiratory syndrome SjTREC syndrome T-cell receptor telomere Telomere length. the SARS-CoV-2 These data vaccination virus [DOI] 10.1016/j.fsigen.2022.102724 PMC 바로가기 [Article Type] Article
COVID-19-specific metabolic imprint yields insights into multiorgan system perturbationsCOVID-19 관련 대사 흔적은 다기관 시스템 섭동에 대한 통찰력을 제공합니다Article Published on 2022-03-012022-09-11 Journal: European Journal of Immunology [Category] MERS, SARS, 유전자 메커니즘, 진단, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 Affect aligned alteration capture cellular circulating metabolome Comorbidities Comorbidity confounding factor Corona Coronavirus-2 COVID-19 COVID-19 severity damage defined disease driven by hospitalized COVID-19 patient immune activation immunological immunology indicated Inflammation integration metabolite metabolome metabolomics molecular multi Multi-omics Multiorgan multiple pathway multiple pathways network Neuroinflammation neurological organ damage organ systems performed Perturbation perturbations proteomic question recent resource respiratory SARS-CoV-2 SARS-CoV-2. Seroconversion severe acute respiratory syndrome Coronavirus severe COVID-19 patients severity switch trajectory unique [DOI] 10.1002/eji.202149626 PMC 바로가기 [Article Type] Article
Insights on the mutational landscape of the SARS-CoV-2 Omicron variant receptor-binding domainSARS-CoV-2 Omicron 변이 수용체 결합 도메인의 돌연변이 환경에 대한 통찰력Article Published on 2022-01-242022-09-11 Journal: Cell Reports Medicine [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] Amino acid analyses antibody antibody epitopes antibody escape antigenic antigenic drift breadth conformational Disruption domain driving epistasis epitope epitope-paratope Epitopes Evidence feature initial insight Interaction interface Mutation network analysis neutralization omicron Omicron variant Perturbation perturbations Point mutation predicted RBD RBD interface stability RBD mutations resulting SARS-CoV-2 sequence stability the RBD the SARS-CoV-2 therapeutic therapeutic antibodies Transmissibility variant Variant of concern. [DOI] 10.1016/j.xcrm.2022.100527 PMC 바로가기 [Article Type] Article
COVID-19 in Joint Ageing and Osteoarthritis: Current Status and Perspectives관절 노화 및 골관절염의 COVID-19: 현황 및 전망Review Published on 2022-01-102022-09-12 Journal: International Journal of Molecular Sciences [Category] 진단, [키워드] accelerated adipose Adipose tissue Ageing aging aging process analyzed angiotensin angiotensin-converting enzyme 2 calcium Characteristics Connective tissues contribute COVID-19 COVID-19 patients current deficiency dysfunction Effect endothelial evaluated explain exploration expression hypovitaminosis Hypovitaminosis D Inflammation joint joint and muscle pain knowledge long-COVID long-lasting molecular morbidity muscle pain Musculoskeletal musculoskeletal aging musculoskeletal symptom neuronal function new treatment strategy Osteoarthritis Pain Perturbation perturbations phenotype primary site recent Renin renin-angiotensin system road SARS-CoV-2 Society status Symptom tissue Topic Treatment [DOI] 10.3390/ijms23020720 PMC 바로가기 [Article Type] Review
Systematic identification of ACE2 expression modulators reveals cardiomyopathy as a risk factor for mortality in COVID-19 patientsACE2 발현 조절제의 체계적인 식별은 심근병증을 COVID-19 환자의 사망 위험 인자로 밝혀줍니다Research Published on 2022-01-102022-09-11 Journal: Genome Biology [Category] 유전자 메커니즘, [키워드] ACE2 ACE2 expression Analysis angiotensin angiotensin-converting enzyme 2 Cardiomyopathy cardiovascular conditions categories characterized Comprehensive condition COVID-19 illness COVID-19 patient COVID-19 patients Critical dataset datasets develop disease drug drug treatment drug treatments drugs Electronic health record Electronic health records enzyme expression Genetic healthy heart HNF1A human tissue identify increased mortality Infection itraconazole joint Mortality overexpression Pathogenesis pathogenesis of COVID-19 Patient perturbations RAD140 receptor Result reveal risk risk factor Risk factors RNA-Seq SARS-CoV-2 SARS-COV-2 infection Seven severe COVID-19 illness supplementary material Transmission upregulation variance while [DOI] 10.1186/s13059-021-02589-4 PMC 바로가기 [Article Type] Research
Prediction and analysis of microRNAs involved in COVID-19 inflammatory processes associated with the NF-kB and JAK/STAT signaling pathwaysNF-kB 및 JAK/STAT 신호 전달 경로와 관련된 COVID-19 염증 과정에 관여하는 microRNA의 예측 및 분석Review Published on 2021-11-012022-09-11 Journal: International immunopharmacology [Category] SARS, 유전자 메커니즘, [키워드] activated Acute inflammation Analysis approved Cityscape connection contribute COVID-19 COVID-19 complications COVID-19 disease COVID-19 patient Critical Diseases Evidence exacerbate feature Host Inflammation Inflammatory inflammatory gene inflammatory genes inflammatory pathway inflammatory pathways inflammatory process Inflammatory response Inflammatory responses Interaction involved JAK-STAT signaling pathway JAK/STAT JAK/STAT signaling pathway manifestation microRNA miR-214 miR-223 miR-9 miRNA miRNA. miRNAs mitigate morbidity and mortality NF-kB non-coding RNA Non-coding RNAs pandemic pathophysiological mechanism pathway Perturbation perturbations prediction Previous studies previous study Regulation STAT target target gene Target genes therapeutic target therapeutic targets virus [DOI] 10.1016/j.intimp.2021.108071 PMC 바로가기 [Article Type] Review
Confronting false discoveries in single-cell differential expressionArticle Published on 2021-09-282022-10-04 Journal: Nature Communications [Category] 유전자 메커니즘, 진단, [키워드] absence biological replicates Computational biology and bioinformatics differential expression Differential expression analysis differentially expressed gene Differentially expressed genes disease dissect Functional genomics Gene expression analysis identify Perturbation perturbations response single-cell Spinal cord injury statistical Statistics transcriptomics trauma Variation while [DOI] 10.1038/s41467-021-25960-2 PMC 바로가기 [Article Type] Article