Comparative RNA-Seq of Ten Phaeodactylum tricornutum Accessions: Unravelling Criteria for Robust Strain Selection from a Bioproduction Point of ViewArticle Published on 2024-07-302024-09-05 Journal: Marine Drugs [Category] update2024, [키워드] biologics bioproduction Diatom microalgae P. tricornutum pharmaceutical recombinant proteins RNA-Seq [DOI] 10.3390/md22080353 PMC 바로가기 [Article Type] Article
A Roadmap for Using Causal Inference and Machine Learning to Personalize Asthma Medication SelectionViewpoint Published on 2024-04-172024-09-05 Journal: JMIR Medical Informatics [Category] update2024, [키워드] artificial intelligence Asthma Causal inference Corticosteroid Corticosteroids customized Decision support drug drugs Forecast Forecasting ICS Inhaled inhaled corticosteroid inhaler machine learning medication medication selection medications personalized pharmaceutic pharmaceutical Pharmaceuticals Pharmaceutics pharmacies Pharmacology pharmacotherapy Pharmacy pulmonary respiratory [DOI] 10.2196/56572 PMC 바로가기 [Article Type] Viewpoint
The Role of Small Molecules Containing Fluorine Atoms in Medicine and Imaging ApplicationsReview Published on 2024-02-222024-09-05 Journal: Pharmaceuticals [Category] update2024, [키워드] chromophore Dye fluorine fluorophore imaging pharmaceutical [DOI] 10.3390/ph17030281 PMC 바로가기 [Article Type] Review
The Effect of Nonpharmaceutical Interventions Implemented in Response to the COVID-19 Pandemic on Seasonal Respiratory Syncytial Virus: Analysis of Google Trends DataArticle Published on 2022-12-212023-07-11 Journal: Journal of Medical Internet Research [Category] COVID19(2023년), [키워드] children COVID-19 Google Google Trends Health Infection Intervention pandemic pharmaceutical respiratory respiratory syncytial virus RSV search engine virus [DOI] 10.2196/42781 PMC 바로가기
Immunogenicity and safety of BNT162b2 mRNA vaccine in Chinese adults: A phase 2 randomised clinical trialArticle Published on 2022-12-012022-10-06 Journal: The Lancet Regional Health - Western Pacific [Category] 진단, [키워드] acute respiratory syndrome Administered Adults adverse event AEs age Analysis assessment assigned BNT162b2 BNT162b2 mRNA BNT162b2 mRNA vaccine China Chinese clinical trial Complete Completed conducted coronavirus COVID-19 development dose double-blind Efficacy and safety enrolled Follow-up geometric mean titer GMT GMTs Han Chinese healthy immune response immunogenicity immunogenicity endpoint Inc independent individual injection intramuscular Intramuscular injection investigators Laboratory parameters management messenger Messenger RNA Mild moderate mRNA vaccine Neutralising Antibodies neutralising antibody of BNT162b2 participant Participants pharmaceutical Placebo placebo-controlled trial randomisation randomised Randomly reactogenicity receive recipients recruited reduced remained reported resolved Result robust Safety SARS-CoV-2 SARS-CoV-2 variant SCR second dose sera serious AE seroconversion rate severity Shanghai Sponsor statisticians stratified T-cell Response the placebo group Tolerability Treatment Trial utilised vaccination vaccine administration were blinded [DOI] 10.1016/j.lanwpc.2022.100586 PMC 바로가기 [Article Type] Article
Development and applications of diffusive gradients in thin films for monitoring pharmaceuticals in surface watersResearch article Published on 2022-10-012022-10-05 Journal: Environmental pollution (Barking, Essex : 1987) [Category] 치료제, [키워드] antibiotic antiviral drug antiviral drugs average comparable Concentration contaminant coronavirus disease COVID-19 demonstrated development Diffusive gradients in thin films (DGT) ecological Effect exhibited Health include independent linear pharmaceutical Pharmaceuticals Previous studies provided raised reduce released required robust Treatment [DOI] 10.1016/j.envpol.2022.119979 [Article Type] Research article
RP-HPLC Method Development, Validation, and Drug Repurposing of Sofosbuvir Pharmaceutical Dosage Form: A Multidimensional StudyResearch article Published on 2022-09-012022-10-05 Journal: Environmental research [Category] COVID19(2023년), SARS, 신약개발, [키워드] Accuracy Agilent binding can be used carried Cell Chromatograph clinical trial complex component correlation coefficient demonstrated Detector development dosage drug Dynamics effective experiment forms high affinity hydrogen bonds Infection injected interacting residue less linear liquid methanol molecular docking Nsp12 occurred parameter parameters pharmaceutical Phenomenex phosphoric acid Photodiode Precision pump quantification ranged repurposing sofosbuvir specificity Standard deviation temperature thresholds treating COVID-19 USA validation was used [DOI] 10.1016/j.envres.2022.113282 [Article Type] Research article
SARS-CoV-2 accelerated clearance using a novel nitric oxide nasal spray (NONS) treatment: A randomized trialArticle Published on 2022-08-012022-10-06 Journal: Lancet Reg Health Southeast Asia [Category] 진단, [키워드] 1:1 95% CI accelerate accelerated age Anti-viral treatment assessment baseline clearance clinical trial Comorbidities comparable Concentration COVID-19 COVID-19 illness defined demonstrated double-blind Endpoint evaluated funding greater greater transmissibility high risk individuals infected with SARS-CoV-2 Laboratory Limited median Mild multicentre mutate nasal Nasal spray nasal swab nitric oxide nostril parallel group Patient pharmaceutical Placebo placebo-controlled polymerase chain primary analysis population progression proportion provided Randomized randomized trial receiving reduce reverse transcription RT-PCR SARS-CoV-2 SARS-CoV-2 RNA secondary Seven study medication symptomatic the placebo group therapy Treatment treatment difference vaccination Viral load virus virus clearance virus RNA [DOI] 10.1016/j.lansea.2022.100036 PMC 바로가기 [Article Type] Article
Environmentally azithromycin pharmaceutical wastewater management and synergetic biocompatible approaches of loaded azithromycin@hematite nanoparticles환경적으로 아지스로마이신 제약 폐수 관리 및 로딩된 아지트로마이신@적철석 나노입자의 상승적 생체 적합성 접근법Article Published on 2022-06-292022-09-11 Journal: Scientific Reports [Category] COVID19(2023년), SARS, 진단, 치료제, [키워드] activity Adsorption adsorption capacity Antibacterial antibacterial activity antibiotic anticancer Antiviral antiviral activities antiviral activity approach Azithromycin Bacteria biosynthesized Cancer cell line Concentration condition conducted contaminant Contamination COVID-19 virus cytotoxicity described dose Echinacea experiments gram Gram-negative bacteria Hematite HepG2 investigated isothermal kinetic Kinetics Langmuir model management manifested parameter pharmaceutical platform R 2 removal reported SARS-CoV-2 strain synergistic synergistic effect therapeutic therapeutic index thermodynamic Treatment virus [DOI] 10.1038/s41598-022-14997-y PMC 바로가기 [Article Type] Article
Safety and immunogenicity of NVX-CoV2373 (TAK-019) vaccine in healthy Japanese adults: Interim report of a phase I/II randomized controlled trial건강한 일본 성인을 대상으로 한 NVX-CoV2373(TAK-019) 백신의 안전성 및 면역원성: I/II상 무작위 대조 시험 중간 보고Clinical Trial Published on 2022-05-262022-09-12 Journal: Vaccine [Category] COVID19(2023년), MERS, SARS, 임상, 진단, [키워드] 95% confidence interval Adults adverse event AEs age AMED anti-SARS-CoV-2 immune response antibody ARMS company conducted COVID-19 Data analysis demonstrated development dose enrolled evaluated Follow-up geometric healthy IgG immune response immunogenicity injection injection site pain Interim Japan Japanese Japanese adults Limited NVX-CoV2373 occurred outcome participant Participants pharmaceutical Placebo placebo-controlled trial Protein Randomized Randomized controlled trial receive reported robust Safety SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 nanoparticle vaccine SARS-CoV-2 vaccine screened second dose seroconversion rate serum IgG stratified subject Takeda vaccination Vaccine [DOI] 10.1016/j.vaccine.2022.04.035 PMC 바로가기 [Article Type] Clinical Trial