Efficacy and marginal cost of treatment with tocilizumab in COVID-19 patientsObservational Study Published on 2023-01-012023-07-11 Journal: Farmacia hospitalaria : órgano oficial de expresión científica de la [Category] COVID19(2023년), [키워드] Asistencia sanitaria delivery of health care Farmacoeconomía Farmacología pharmacoeconomics Pharmacology SARS-CoV-2 tocilizumab. [DOI] 10.1016/j.farma.2022.12.003 PMC 바로가기 [Article Type] Observational Study
[Translated article] Efficacy and marginal cost of treatment with tocilizumab in COVID-19 patientsObservational Study Published on 2023-01-012023-07-11 Journal: Farmacia hospitalaria : órgano oficial de expresión científica de la [Category] COVID19(2023년), [키워드] Asistencia sanitaria delivery of health care Farmacoeconomía Farmacología pharmacoeconomics Pharmacology SARS-CoV-2 tocilizumab. [DOI] 10.1016/j.farma.2022.12.014 PMC 바로가기 [Article Type] Observational Study
Recent review of COVID-19 management: diagnosis, treatment and vaccinationReview Published on 2022-12-012023-07-10 Journal: Pharmacological Reports [Category] COVID19(2023년), [키워드] complications COVID-19 Diagnosis and treatment novel Pharmacology Repurpose drugs SARS-CoV-2 Vaccines. [DOI] 10.1007/s43440-022-00425-5 PMC 바로가기 [Article Type] Review
Calibration and Validation of a Mechanistic COVID-19 Model for Translational Quantitative Systems Pharmacology – A Proof-of-Concept Model Development for RemdesivirArticle Published on 2022-10-012022-11-15 Journal: Clinical Pharmacology and Therapeutics [Category] COVID19(2023년), SARS, 치료제, [키워드] accelerate Administered antibody approach calibrated calibration clinical Clinical data Clinical outcome clinical setting clinical study Clinical trial design coronavirus disease Course COVID-19 COVID-19 disease COVID-19 therapeutics Cytokines development disease drug candidate example global pandemic immune responses immunological in silico include intravenously lymphopenia metabolism metabolite Mild Model Patient pharmacological Pharmacology Placebo predict provide quantitative framework Remdesivir responses severe COVID-19 System the disease the primary endpoint Therapies therapy Time to recovery translate validation viral titer virus infection [DOI] 10.1002/cpt.2686 PMC 바로가기
Understanding the Pharmacology of COVID-19 mRNA Vaccines: Playing Dice with the Spike?Article Published on 2022-09-172022-11-15 Journal: International Journal of Molecular Sciences [Category] SARS, 유전자 메커니즘, 진단, [키워드] adverse effects Antigen complex conventional vaccines COVID-19 COVID-19 mRNA vaccine Dice drug Effect emergency condition Evidence implication mechanism of action mRNA mRNA vaccine mRNA vaccines Pharmacodynamics pharmacokinetic pharmacokinetics Pharmacology representing resulting S protein Safe Safety Safety assessment SARS-CoV-2 SARS-CoV-2 S protein Spike protein spike protein. the SARS-CoV-2 took place translation undergo understanding vaccination [DOI] 10.3390/ijms231810881 PMC 바로가기
Transcriptomics, Cheminformatics, and Systems Pharmacology Strategies Unveil the Potential Bioactives to Combat COVID-19Article Published on 2022-09-132022-11-16 Journal: Molecules [Category] SARS, 유전자 메커니즘, [키워드] addition analysis analyzed approach caused Cheminformatics co-expression combat Complete COVID-19 determine disease drug candidate Efficiency Features functional Genetic higher efficiency identify immune immune gene Infection Laboratory lack mechanism molecular molecular docking molecular docking analysis Mutation pathway enrichment pharmacological Pharmacology Phytocompounds plant plants Potential Prevalence Regulation required SARS-CoV-2 selected Side effects Signaling Strategy System systems pharmacology. the SARS-CoV-2 virus therapeutic these compound transcriptomics transmission rate treat unique unique genes Vaccinations viral disease [DOI] 10.3390/molecules27185955 PMC 바로가기
Network Pharmacology and Bioinformatics Analysis Identifies Potential Therapeutic Targets of Paxlovid Against LUAD/COVID-19Article Published on 2022-09-082022-11-16 Journal: Frontiers in Endocrinology [Category] SARS, 유전자 메커니즘, [키워드] acute respiratory syndrome Against Analysis approved bioinformatics bioinformatics. caused Clinical characteristics Clinical data contagious coronavirus Coronavirus disease 2019 correlation country COVID-19 COX Cytoscape downloaded drug drug target DrugBank evaluate evaluated Fatality rate FDA Features food functional Gene Expression GeneCards Genes GO enrichment analysis IL-17 IL12B IL6 include infected with COVID-19 Interaction KEGG LBP lung adenocarcinoma (LUAD) lung cancer patient management mechanism modulate molecular molecular docking Mortality NCBI network network pharmacology pandemic pathway Pathway analysis Patient Paxlovid Pharmacology Potential potential therapeutic target Prognosis prognostic receptor Regression model risk SARS-CoV-2 screened signaling pathway survival rate susceptibility SwissTargetPrediction target target gene TargetNet therapeutic target Transcriptome Treatment Venn diagram virus was performed was used while [DOI] 10.3389/fendo.2022.935906 PMC 바로가기
Network analysis for elucidating the mechanisms of Shenfu injection in preventing and treating COVID-19 combined with heart failureResearch article Published on 2022-09-012022-10-05 Journal: Computers in biology and medicine [Category] COVID19(2023년), SARS, 바이오마커, 유전자 메커니즘, [키워드] acting acute respiratory syndrome Analysis approach biological process biological processe caused cell differentiation China Chinese components Compound compound screening coronavirus COVID-19 COVID-19 case Critical cytokine signaling Cytoscape Cytoscape software Diagnosis drug-likeness Effectiveness enrichment analysis Evidence heart failure Hemostasis identify IL-17 immune system indicated Infection Inflammatory response injection involved KEGG pathway Kyoto Lung injury mechanism Medicine National Health Commission network network analysis novel coronavirus disease objective overlapped Pathway analysis Pathway enrichment analysis Pathways patients with COVID-19 pharmacological mechanism Pharmacological mechanisms Pharmacology progression protein-protein interaction regulated Respiratory failure Result SARS-CoV-2 Shenfu injection signaling pathway Stage suggested syndrome System target targets TCM Th17 therapeutic therapy Traditional treat treating COVID-19 Treatment was used [DOI] 10.1016/j.compbiomed.2022.105845 [Article Type] Research article
Safety pharmacology in 2022: Taking one small step for cardiovascular safety assay development but one giant leap for regulatory drug safety assessmentArticle Published on 2022-09-012022-11-16 Journal: Journal of Pharmacological and Toxicological Methods [Category] 신약개발, [키워드] Abstract Analysis Annual appear approach arising article assessments attrition automated clinical study COVID-19 drug effort FDA Giant global pandemic hERG. ICHE14/S7B in vitro in vivo manuscript Perspective Pharmacology Prevent problem protocol QT correction Regulatory Safety Safety assessment safety pharmacology Society SPS Taking Volume [DOI] 10.1016/j.vascn.2022.107206 PMC 바로가기
Effect of nirmatrelvir/ritonavir on calcineurin inhibitor levels: Early experience in four SARS-CoV-2 infected kidney transplant recipientsComment Published on 2022-08-012023-07-08 Journal: American journal of transplantation : official jou [Category] COVID19(2023년), [키워드] clinical research/practice drug interaction immunosuppressant - calcineurin inhibitor (CNI) infection and infectious agents-viral: SARS-CoV-2/COVID-19 Infectious disease Pharmacology solid organ transplantation. [DOI] 10.1111/ajt.16997 PMC 바로가기 [Article Type] Comment