Efficacy, safety, and pharmacokinetics of capsid assembly modulator linvencorvir plus standard of care in chronic hepatitis B patientsOriginal Article Published on 2024-04-082024-09-05 Journal: Clinical and molecular hepatology [Category] update2024, [키워드] capsid assembly modulator Chronic Hepatitis B Linvencorvir Phase 2 RO7049389 [DOI] 10.3350/cmh.2023.0422 PMC 바로가기 [Article Type] Original Article
Rationale and Design of a Phase 2, Double-blind, Placebo-Controlled, Randomized Trial Evaluating AMP Kinase-Activation by Metformin in Focal Segmental GlomerulosclerosisClinical Research Published on 2024-02-132024-09-05 Journal: Kidney International Reports [Category] update2024, [키워드] Adjunctive therapy AMP-activated protein kinase focal segmental glomerulosclerosis metformin Phase 2 randomized trial [DOI] 10.1016/j.ekir.2024.02.006 PMC 바로가기 [Article Type] Clinical Research
One Week of Oral Camostat Versus Placebo in Nonhospitalized Adults With Mild-to-Moderate Coronavirus Disease 2019: A Randomized Controlled Phase 2 TrialMajor Article Published on 2023-10-012024-09-05 Journal: Clinical Infectious Diseases: An Official Publicat [Category] update2024, [키워드] camostat COVID-19 Outpatient Phase 2 SARS-CoV-2 [DOI] 10.1093/cid/ciad342 PMC 바로가기 [Article Type] Major Article
A randomized phase I/II safety and immunogenicity study of the Montanide-adjuvanted SARS-CoV-2 spike protein-RBD-Fc vaccine, AKS-452Article Published on 2023-02-232024-09-05 Journal: Vaccine [Category] update2024, [키워드] AKS-452 coronavirus COVID-19 Fc-fusion Infectious disease pandemic Phase 2 Prophylaxis SARS-CoV-2 Vaccine [DOI] 10.1016/j.vaccine.2023.02.057 PMC 바로가기 [Article Type] Article
Safety and immunogenicity of MVC-COV1901 vaccine in older adults: Phase 2 randomized dose-comparison trialArticle Published on 2022-11-012022-11-15 Journal: International Journal of Infectious Diseases [Category] 진단, [키워드] Administered adverse event age binding antibody clinical trial Comorbidities Comorbidity COVID-19 infection demonstrated dose double-blind elicited General population High dose High-dose immune response immunization immunogenicity immunosenescence Mild mortality rates MVC-COV1901 vaccine negative correlation Neutralizing Older older adult Older adults participant Phase 2 protein subunit vaccine Randomized regimen Registered robust Safety SARS-CoV-2 stratified subject Trial Vaccine [DOI] 10.1016/j.ijid.2022.08.021 PMC 바로가기
Safety and efficacy of vebicorvir administered with entecavir in treatment-naïve patients with chronic hepatitis B virus infectionClinical Trial Published on 2022-11-012023-06-13 Journal: Journal of hepatology [Category] B형 간염, [키워드] ABI-H0731 Chronic hepatitis B virus core inhibitor entecavir nucleos(t)ide reverse transcriptase inhibitor Phase 2 treatment-naive Vebicorvir [DOI] 10.1016/j.jhep.2022.05.027 [Article Type] Clinical Trial
Favipiravir, lopinavir-ritonavir, or combination therapy (FLARE): A randomised, double-blind, 2 × 2 factorial placebo-controlled trial of early antiviral therapy in COVID-19Article Published on 2022-10-192022-11-15 Journal: PLoS Medicine [Category] COVID19(2023년), SARS, 치료제, [키워드] 95% CI Administered administration Adverse affected analysed antiviral therapy Antiviral treatment ARMS baseline changed Combination combination therapy concentrations conducted coronavirus 2 COVID-19 COVID-19 pandemic Day Dose escalation doses double-blind double-blind trial drug level effective Efficacy evaluate the effect event Favipiravir healthy Interaction Lopinavir-ritonavir measure monotherapy Odds ratio Outpatient participant Participants Phase 2 Placebo placebo-controlled placebo-controlled trial placebos plasma primary analysis Primary outcome provided randomised recruited reduced respiratory SARS-CoV-2 SARS-CoV-2 viral load significant interaction significantly study population symptom onset the mean trajectory Treatment undetectable United Kingdom Viral load virus [DOI] 10.1371/journal.pmed.1004120 PMC 바로가기
Wellbeing and coping of UK nurses, midwives and allied health professionals during COVID-19-a cross-sectional studyArticle Published on 2022-09-212022-11-16 Journal: PLoS ONE [Category] SARS, 변종, [키워드] backbone benefit Burnout Care conducted COPE coping coping strategies Coping strategy COVID-19 pandemic cross-sectional cross-sectional survey Descriptive statistics Deterioration Effect examined family Final Health healthcare Healthcare professional healthcare services inventory life mental health Multiple linear regression Nurse Nurses patients with COVID-19 phase Phase 1 Phase 2 Prevent professional Psychological Quality repeated respond scale significant effect significantly lower Strategy Stressor timepoints United Kingdom variable variant work [DOI] 10.1371/journal.pone.0274036 PMC 바로가기
Landscape of new drugs and targets in inflammatory bowel diseaseInflammatory Bowel Disease Published on 2022-09-162024-09-04 Journal: United European gastroenterology journal [Category] 대상포진, [키워드] clinical trials Inflammatory bowel disease New drugs Phase 1 Phase 2 Phase 3 [DOI] 10.1002/ueg2.12305 PMC 바로가기 [Article Type] Inflammatory Bowel Disease
Safety and immunogenicity of SpikoGen®, an Advax-CpG55.2-adjuvanted SARS-CoV-2 spike protein vaccine: a phase 2 randomized placebo-controlled trial in both seropositive and seronegative populationsArticle Published on 2022-09-012022-11-15 Journal: Clinical microbiology and infection : the official [Category] COVID19(2023년), SARS, 진단, [키워드] Advax-CpG adverse event antibody Cellular immune response composed conducted COVID-19 COVID-19 vaccine dose double-blind fatigue geometric mean concentration humoral incidence injection site pain Mild outcome participant phase Phase 2 phase 2 trial Placebo placebo-controlled Population primary immunogenicity Protein Randomized randomized placebo-controlled trial receive Safety safety profile SARS-CoV-2 SARS-CoV-2 spike protein second dose Serious Adverse Event Seroconversion seroconversion rate seronegative seropositive SpikoGen subunit subunit protein vaccine the placebo group vaccination Vaccine Volunteer were recorded [DOI] 10.1016/j.cmi.2022.04.004 PMC 바로가기