Maturation of the malarial phosphatidylserine decarboxylase is mediated by high affinity binding to anionic phospholipids말라리아 인지질세린 탈카복실화효소의 성숙은 음전하 인지질에 대한 높은 친화력 결합에 의해 매개된다.Article Published on 2023-03-292024-08-01 Journal: Brain stimulation [Category] 말라리아, [키워드] anionic phospholipid cardiolipin enzyme regulation Liposome phosphatidic acid Phosphatidylcholine phosphatidylethanolamine phosphatidylglycerol Phosphatidylserine phosphatidylserine decarboxylase proenzyme processing solid phase binding surface plasmon resonance [DOI] 10.1016/j.jbc.2023.104659 PMC 바로가기
Lipidomics Revealed Plasma Phospholipid Profile Differences between Deceased and Recovered COVID-19 PatientsArticle Published on 2022-10-152022-11-15 Journal: Biomolecules [Category] 진단, [키워드] abnormality addition analyzed Anemia appear autoantibody changes characterized control group coronavirus COVID-19 COVID-19 patients CRP level Deceased decrease difference disorder disorders FIVE healthy immune system increase in Increased LDH Lipidomics Liver damage low-density Low-density lipoprotein majority Modification oxidative oxidative stress pathophysiological Patient patients Phosphatidylcholine Phosphatidylserine phospholipid Phospholipids plasma profile profiles Prognostic value recovered recovered patient recovered patients reported Revealed SARS-CoV-2 significantly two subgroup [DOI] 10.3390/biom12101488 PMC 바로가기
Dynamic modulations of sphingolipids and glycerophospholipids in COVID-19Article Published on 2022-10-012022-11-15 Journal: Clinical and Translational Medicine [Category] 바이오마커, [키워드] Administered association biological properties Biomarker ceramide characteristic clinical phenotype conditions control subject coronavirus disease Course COVID-19 Critical CRP D-dimer decrease develop disease severity dynamic early phase glycerophospholipids heterogeneity heterogeneous Infectious disease Laboratory testing Lipidomics lysophosphatidylcholine mechanism mice modulation negative correlation Phosphatidylcholine positive Prevent responsible serum severe COVID-19 severity shown sphingolipid sphingolipids sphingomyelin subject subjects suppress tissue treated unsaturated [DOI] 10.1002/ctm2.1069 PMC 바로가기
Immunometabolic analysis shows a distinct cyto-metabotype in Covid-19 compared to sepsis from other causesResearch article Published on 2022-06-242022-10-05 Journal: Heliyon [Category] 바이오마커, 치료기술, [키워드] accompanied Analysis cause CD14+ CD14+ monocyte CD8+ T cells change characteristic Cohort concentrations controls correlated COVID-19 Critical cytokine Cytokine release syndrome Disease progression disease severity expression flow cytometry greater healthy control Hypothesis immune checkpoint immune response immunometabolism involved Lipid mechanism metabolic derangement metabolic risk factor metabolism monocytopenia mononuclear cell multiplex pandemic Pathway analysis Patient PBMC PBMCs PD-L1 Peripheral blood Phosphatidylcholine plasma plasma concentration recruited reduced reflect Result Sepsis serum severe cases severity shown SOFA score Support systemic inflammatory response the disease Treg Tryptophan unique was increased was performed [DOI] 10.1016/j.heliyon.2022.e09733 [Article Type] Research article
Reduced DMPC and PMPC in lung surfactant promote SARS-CoV-2 infection in obesity폐 계면활성제의 감소된 DMPC 및 PMPC는 비만에서 SARS-CoV-2 감염을 촉진합니다Article Published on 2022-06-012022-09-11 Journal: Metabolism: clinical and experimental [Category] COVID19(2023년), SARS, 변종, [키워드] ACE2 ACE2 expression ACE2 receptor Analysis BALF bind Bronchoalveolar lavage fluid cell-cell fusion assay characterized cholesterol COVID-19 COVID-19 disease COVID-19 pneumonia D614G mutant SARS-CoV-2 Defense DMPC Effect effector cells elevated expressing fat Feeding HEK293T HEK293T cell HEK293T cells High fat diet Hospitalization increased risk Increasing Infection infections inhibited inhibitory effect Inhibitory effects Lipid lipid composition lipid metabolism lipids lung lung surfactant lung tissue Lungs mechanism metabolism mice myristic acid obese obesity outcomes overexpression Phosphatidylcholine Pneumocytes produced promote Protein reduced respiratory virus reversed risk factor SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 pseudovirus infection SARS-CoV-2 viral loads severe COVID-19 disease Severe COVID-19 pneumonia Spike protein surfactant the Spike Triglyceride triglycerides trimyristin Type II pneumocyte type II pneumocytes Vero-E6 cell Vero-E6 cells was performed were used wild type [DOI] 10.1016/j.metabol.2022.155181 PMC 바로가기 [Article Type] Article
Machine learning and semi-targeted lipidomics identify distinct serum lipid signatures in hospitalized COVID-19-positive and COVID-19-negative patientsResearch article Published on 2022-06-012022-10-05 Journal: Metabolism: clinical and experimental [Category] 바이오마커, 진단, 치료기술, [키워드] alteration Analysis analyzed arachidonic acid artificial intelligence bile acid cause clinical decision COVID-19 COVID-19 infection disease Diseases healthy subject healthy subjects healthy volunteers highlight Hospitalized hospitalized patient Host identify immunological responses IMPROVE Inflammation Interaction involved Lipid lipid metabolism Lipidomics machine machine learning machine learning algorithm notable parameter pathophysiology Patient patients patients hospitalized Phosphatidylcholine quantified reported Result secondary bile acid serum the healthy viral infection was performed [DOI] 10.1016/j.metabol.2022.155197 [Article Type] Research article
Citicoline and COVID-19-Related Cognitive and Other Neurologic ComplicationsReview Published on 2021-12-312022-10-28 Journal: Brain Sciences [Category] COVID-19, [키워드] Anti-inflammation Anti-viral Brain cells citicoline clinical trials cognitive Cognitive function Complication contribute COVID-19 Effect Effects Hyperinflammatory mechanism metabolite neurologic Neurological complications Neurological disease Neurovascular Other Phosphatidylcholine potential treatment option precursor therapy Treatment variety while [DOI] 10.3390/brainsci12010059 PMC 바로가기 [Article Type] Review
Scrutinizing the Feasibility of Nonionic Surfactants to Form Isotropic Bicelles of Curcumin: a Potential Antiviral Candidate Against COVID-19Research Article Published on 2021-12-292022-10-27 Journal: AAPS PharmSciTech [Category] COVID-19, [키워드] Against antiviral activity antiviral therapy benefit Bicelles candidate clinical study conditions COVID-19 COVID-19 patients docking ENhance Ex vivo exhibited form hydrophobic drug investigated Liposome mechanism Mixed micelles molecular docking Non-ionic surfactants permeation Phosphatidylcholine Potential SARS-CoV-2 significantly surfactant TEM therapeutic was used [DOI] 10.1208/s12249-021-02197-2 PMC 바로가기 [Article Type] Research Article
Scrutinizing the Feasibility of Nonionic Surfactants to Form Isotropic Bicelles of Curcumin: a Potential Antiviral Candidate Against COVID-19Research Article Published on 2021-12-292022-10-27 Journal: AAPS PharmSciTech [Category] Coronavirus, COVID-19, SARS, [키워드] Against antiviral activity antiviral therapy benefit Bicelles candidate clinical study conditions COVID-19 COVID-19 patients docking ENhance Ex vivo exhibited form hydrophobic drug investigated Liposome mechanism Mixed micelles molecular docking Non-ionic surfactants permeation Phosphatidylcholine Potential SARS-CoV-2 significantly surfactant TEM therapeutic was used [DOI] 10.1208/s12249-021-02197-2 PMC 바로가기 [Article Type] Research Article
Scrutinizing the Feasibility of Nonionic Surfactants to Form Isotropic Bicelles of Curcumin: a Potential Antiviral Candidate Against COVID-19비 이온 성 계면 활성제의 실현 가능성을 면밀히 조사하여 커큐민의 등방성 비 셀을 형성 : Covid-19에 대한 잠재적 인 항 바이러스 후보Research Article Published on 2021-12-292022-09-10 Journal: AAPS PharmSciTech [Category] 치료제, [키워드] Against antiviral activity antiviral therapy benefit Bicelles candidate Clinical studies clinical study conditions COVID-19 COVID-19 patients cremophor EL Curcumin docking drug delivery system ENhance Ex vivo exhibited form hydrophobic drug investigated Liposome mechanism Mixed micelles molecular docking Non-ionic surfactants permeation Phosphatidylcholine Potential SARS-CoV-2 significantly surfactant TEM therapeutic tween was used [DOI] 10.1208/s12249-021-02197-2 PMC 바로가기 [Article Type] Research Article