phosphatidylinositol 3-kinase – Communicable Diseases Research

Exploring potential mechanisms of Suhexiang Pill against COVID-19 based on network pharmacology and molecular docking

네트워크 약리학 및 분자 도킹을 기반으로 Covid-19에 대한 수 헥치 안약의 잠재적 메커니즘 탐색

4200

Published on 2021-12-232022-08-31
Journal: Medicine [Category] 유전자 메커니즘, 치료제,

[키워드] activator Analysis Anti-viral applied AutoDock binding affinity biological processe cells chemokine Chinese classic collected Compound compounds coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 disease Cytokine storm Cytoscape software database Diagnosis disease endothelial epidermal epidermal growth factor Functional enrichment analysis GeneCard Genes growth factor guideline hub genes hypoxia immune function immune system include inflammatory storm ingredient interleukin interleukin 17 interleukin 6 Intersection janus Janus kinase KEGG Kyoto mechanism moderate molecular docking molecular mechanism Necrosis network pharmacology Ontology pathway enrichment Pathways phosphatidylinositol phosphatidylinositol 3-kinase PI3K pill plague platform potential mechanism potential therapeutic targets predicted Protein kinase B protein-protein interaction R language receptor Regulation screened severe COVID-19 signaling pathways STAT3 suggested suhexiang pill synergistic T cell T cell receptor target target gene Target genes targets TNF Traditional Chinese medicine Transcription Treatment Tumor tumor necrosis tumor necrosis factor Vascular Viral viral invasion was used
[DOI] 10.1097/MD.0000000000027112 PMC 바로가기 [Article Type] 4200

Comparative Transcriptomic and Molecular Pathway Analyses of HL-CZ Human Pro-Monocytic Cells Expressing SARS-CoV-2 Spike S1, S2, NP, NSP15 and NSP16 Genes

Article

Published on 2021-05-312022-10-29
Journal: Microorganisms [Category] COVID-19,

[키워드] antigen processing arising binding bioinformatics cell line Comparative complex complications of COVID-19 contribute COVID-19 pandemic Critical disease down-regulated down-regulated gene down-regulation Endoplasmic reticulum endoribonuclease (NSP15) enrichment analysis expression facilitate global public health heart development Heat shock Host host gene Human Immunity insulin signaling pathway Interaction methyltransferase Methyltransferase (NSP16) nervous system neurodegeneration neutrophil degranulation Nucleocapsid (NP) nucleocapsid protein offer oxidative phosphorylation pathway phosphatidylinositol 3-kinase positive Protein Regulation response RNA sequencing RNA-sequencing S1 subunit S2 subunit SARS-CoV-2 SARS-CoV-2 pathogenesis SARS-CoV-2 proteins SARS-CoV-2 virus Signaling signaling pathway spike Spike S1 Spike S2 Stress target host cell transcriptomic transcriptomic alteration up-regulated viral gene viral spike virus receptor
[DOI] 10.3390/microorganisms9061193 PMC 바로가기 [Article Type] Article

Plasmodium falciparum kelch 13: a potential molecular marker for tackling artemisinin-resistant malaria parasites

article

Published on 2016-12-312024-09-01
Journal: Expert review of anti-infective therapy [Category] 말라리아,

[키워드] Artemisinin resistance Kelch13 phosphatidylinositol 3-kinase Plasmodium ubiquitin/proteasome system unfolded protein response pathway
[Article Type] article

Suppression of Virulent Porcine Epidemic Diarrhea Virus Proliferation by the PI3K/Akt/GSK-3α/β Pathway

Research Article

Published on 2016-08-252022-10-28
Journal: PLoS ONE [Category] Coronavirus, MERS,

Beclin 1 Is Required for Neuron Viability and Regulates Endosome Pathways via the UVRAG-VPS34 Complex

Beclin 1은 뉴런 생존에 필요하고 UVRAG-VPS34 복합체를 통해 엔도솜 경로를 조절합니다

Research Article

Published on 2014-10-022022-09-06
Journal: PLoS Genetics [Category] Communicable Disease,

[키워드] activity addition animal model assembly autophagosome autophagy Beclin 1 Brain cause cell line cellular characterized Complete complex complexes conditions Coordinate deficiency disease Diseases Disruption distribution EEA1 endocytosis endosome Endosomes Evidence failure function Genetic human disease impair impairment implicated in addition to in vivo Infectious disease Interaction involved leads maintain mammalian maturation membrane molecular mechanism mutant neurodegeneration neurodegenerative Neuron neuronal neurons nucleation organelle overexpressed p40 pathway Pathways phosphatidylinositol phosphatidylinositol 3-kinase physiological PI3K Previous studies previous study Protein recent recruit recruitment regulate Regulation required rescued reveal RUBICON survival tumorigenesis UVRAG viability
[DOI] 10.1371/journal.pgen.1004626 PMC 바로가기 [Article Type] Research Article