New Therapeutic Strategies in Retinal Vascular Diseases: A Lipid Target, Phosphatidylserine, and Annexin A5—A Future Theranostic Pairing in OphthalmologyReview Published on 2024-07-242024-09-05 Journal: Pharmaceuticals [Category] update2024, [키워드] annexin A5 Anti-VEGF Phosphatidylserine retinal vein occlusion [DOI] 10.3390/ph17080979 PMC 바로가기 [Article Type] Review
The SARS-CoV-2 nucleoprotein associates with anionic lipid membranesResearch Article Published on 2024-06-102024-09-05 Journal: Brain stimulation [Category] update2024, [키워드] lipid-binding protein lipid-protein interaction Phosphatidylserine phosphoinositide RNA virus virus assembly [DOI] 10.1016/j.jbc.2024.107456 PMC 바로가기 [Article Type] Research Article
Anti-phosphatidylserine antibody levels are low in multigravid pregnant women in a malaria-endemic area in Nigeria, and do not correlate with anti-VAR2CSA antibodiesarticle Published on 2023-03-312024-09-01 Journal: Frontiers in Cellular and Infection Microbiology [Category] 말라리아, [키워드] Anemia antibody gravidity malaria P. falciparum Phosphatidylserine VAR2CSA [Article Type] article
Maturation of the malarial phosphatidylserine decarboxylase is mediated by high affinity binding to anionic phospholipids말라리아 인지질세린 탈카복실화효소의 성숙은 음전하 인지질에 대한 높은 친화력 결합에 의해 매개된다.Article Published on 2023-03-292024-08-01 Journal: Brain stimulation [Category] 말라리아, [키워드] anionic phospholipid cardiolipin enzyme regulation Liposome phosphatidic acid Phosphatidylcholine phosphatidylethanolamine phosphatidylglycerol Phosphatidylserine phosphatidylserine decarboxylase proenzyme processing solid phase binding surface plasmon resonance [DOI] 10.1016/j.jbc.2023.104659 PMC 바로가기
Scramblases and virus infectionReview Published on 2022-12-012023-07-10 Journal: Bioessays [Category] COVID19(2023년), [키워드] apoptotic mimicry Phosphatidylserine phospholipid distribution scramblase TMEM16F Tmem41b virus infection VMP1 Xkr8 [DOI] 10.1002/bies.202100261 [Article Type] Review
Lipidomics Revealed Plasma Phospholipid Profile Differences between Deceased and Recovered COVID-19 PatientsArticle Published on 2022-10-152022-11-15 Journal: Biomolecules [Category] 진단, [키워드] abnormality addition analyzed Anemia appear autoantibody changes characterized control group coronavirus COVID-19 COVID-19 patients CRP level Deceased decrease difference disorder disorders FIVE healthy immune system increase in Increased LDH Lipidomics Liver damage low-density Low-density lipoprotein majority Modification oxidative oxidative stress pathophysiological Patient patients Phosphatidylcholine Phosphatidylserine phospholipid Phospholipids plasma profile profiles Prognostic value recovered recovered patient recovered patients reported Revealed SARS-CoV-2 significantly two subgroup [DOI] 10.3390/biom12101488 PMC 바로가기
The impact of platelets on pulmonary microcirculation throughout COVID-19 and its persistent activating factorsArticle Published on 2022-09-282022-11-15 Journal: Frontiers in Immunology [Category] 치료제, [키워드] activate activating addition aggregation antiplatelet Blood coagulation factor complex convalescent COVID-19 COVID-19 patients disease severity disorders endothelial injury Factor Gas exchange hypercoagulability hypercoagulable hypercoagulable states Hypoxemia hypoxia immune cells impaired lung function impairment incidence Inflammation Inflammatory mediators inhibiting Intervention intrinsic involved Lung function manifestation marker microvesicle Microvesicles Mild Mortality Phosphatidylserine Platelet platelet activation Platelets promote PROTECT pulmonary permeability pulmonary vasculitis reactivity reducing resulting risk severe cases stages the disease therapy Thromboembolism thrombosis thrombotic event tissue Treatment vessel walls with COVID-19 [DOI] 10.3389/fimmu.2022.955654 PMC 바로가기
Amelioration of SARS-CoV-2 infection by ANO6 phospholipid scramblase inhibitionArticle Published on 2022-07-192023-07-10 Journal: Cell Reports [Category] COVID19(2023년), [키워드] ANO6/TMEM16F CP: Microbiology Phosphatidylserine SARS-CoV-2 virus-cell fusion. [DOI] 10.1016/j.celrep.2022.111117 PMC 바로가기
Increased suicidal erythrocyte death in patients with hepatitis B-related acute-on-chronic liver failureArticle Published on 2022-06-012023-06-11 Journal: American journal of physiology. Gastrointestinal and liver physiology [Category] B형 간염, [키워드] Acute-on-chronic liver failure eryptosis erythrocyte Phosphatidylserine red blood cell-derived microparticles. [DOI] 10.1152/ajpgi.00050.2020
Design, synthesis and biological evaluations of niclosamide analogues against SARS-CoV-2SARS-CoV-2에 대한 니클로사미드 유사체의 설계, 합성 및 생물학적 평가Article Published on 2022-05-052022-09-11 Journal: European journal of medicinal chemistry [Category] COVID19(2023년), SARS, 치료제, [키워드] Administered analogue anti-SARS-CoV-2 applied autophagy Bioavailability blocked comparable Compound cytotoxicity Efficacy entry inhibition enzyme exhibited Fluorescence fluorescence microscopy half-life Human plasma hydrogen IMPROVE inhibit liver Microscopy molecular docking niclosamide oral bioavailability Phosphatidylserine Protein protein structure reduction Replication SARS-CoV-2 SARS-CoV-2 virus stability Stability test TMEM16F. was related [DOI] 10.1016/j.ejmech.2022.114295 PMC 바로가기 [Article Type] Article