Inhibition of major histocompatibility complex-I antigen presentation by sarbecovirus ORF7a proteins
Article
Published on
Journal: Proceedings of the National Academy of Sciences of [Category] COVID19(2023년), SARS, 유전자 메커니즘,
Journal: Proceedings of the National Academy of Sciences of [Category] COVID19(2023년), SARS, 유전자 메커니즘,
[키워드] absence
acute respiratory syndrome
Affect
Amino acid
Antigen
Antigen presentation
biological activity
caused
CD8
Cell
complex
Coronavirus-2
Cytotoxic T cells
dissemination
down-regulation
downregulating
Endoplasmic reticulum
expressed
histocompatibility complex
human populations
immune responses
Immunity
induce
infected with SARS-CoV-2
Infection
inhibited
inhibition
mechanism
MHC-I
MHC-I down-regulation
ORF7a
orf7a protein
peptide
Peptide loading complex
persistence
physically
prevented
reduced
sarbecovirus
SARS-CoV
SARS-CoV-2
T cells
variety
viral peptide
Viral proteins
[DOI] 10.1073/pnas.2209042119 PMC 바로가기
[DOI] 10.1073/pnas.2209042119 PMC 바로가기