Protein corona and exosomes: new challenges and prospectsarticle Published on 2023-03-272024-09-05 Journal: Cell Communication and Signaling : CCS [Category] update2024, [키워드] biodistribution Exosomes Physicochemical properties Protein corona [DOI] 10.1186/s12964-023-01089-1 PMC 바로가기 [Article Type] article
Evaluation of the relative potential for contact and doffing transmission of SARS-CoV-2 by a range of personal protective equipment materialsArticle Published on 2022-10-052022-11-15 Journal: Scientific Reports [Category] COVID19(2023년), SARS, 치료제, [키워드] acute respiratory syndrome Adsorption aerosol analysed antiviral potency caused Community Contact coronavirus coronavirus disease correlation doffing Efficacy equipment evaluated global public health healthcare Infection Ion m/z negative correlation no correlation Personal protective equipment Physicochemical properties Polymer positive PPE Protective reduction in Regression model SARS-CoV-2 transmission the SARS-CoV-2 titre Transmission transmission of SARS-CoV-2 virion virus while [DOI] 10.1038/s41598-022-20952-8 PMC 바로가기
In silico SARS-CoV-2 vaccine development for Omicron strain using reverse vaccinology역백신학을 이용한 오미크론 균주에 대한 In silico SARS-CoV-2 백신 개발Article Published on 2022-08-012022-09-11 Journal: Genes & genomics [Category] COVID19(2023년), SARS, 변종, [키워드] 3D structure 3D Structures ACE2 ACE2 receptor acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 allergenicity angiotensin angiotensin converting enzyme angiotensin converting enzyme 2 antigenic antigenicity applied B cell epitope B cell epitopes B.1.1.529 binding collected coronavirus develop Efficacy effort enzyme epitope Epitopes estimation final vaccine construct Health Organization in silico MHC I MHC II molecular docking analysis Mutation non-allergenic non-toxic omicron pandemic Physicochemical properties physicochemical property predict predicted Prevent profile RaptorX reduce reverse vaccinology SARS-CoV-2 SARS-CoV-2 vaccine second secondary structure secondary structures selected severe acute respiratory syndrome Coronavirus solubility Spread stability Structure tested the vaccine Toxicity Vaccine vaccine candidate vaccine construct Vaccine design Vaccines variant viral genome sequences virus VoC was performed were used WHO wild type World Health Organization [DOI] 10.1007/s13258-022-01255-8 PMC 바로가기 [Article Type] Article
Molecular Modeling and Simulation Analysis of Antimicrobial Photodynamic Therapy Potential for Control of COVID-19COVID-19 제어를 위한 항균성 광역학 치료 잠재력의 분자 모델링 및 시뮬레이션 분석Article Published on 2022-05-312022-09-11 Journal: The Scientific World Journal [Category] COVID19(2023년), SARS, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus addition Analysis angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 antimicrobial Antiviral binding binding mode binding modes bioinformatics can be used coil Computer simulation Control coronavirus COVID-19 Curcumin described ENhance evaluate functional Hierarchical host cell host cells identity in silico inhibiting Interaction modeling molecular molecular docking photodynamic therapy photosensitizer Physicochemical properties positive Positive Charge Potential predicted Protein protein structure protein-protein interaction random residue residues reveal SARS-CoV-2 secondary structure severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 Simulation spike glycoprotein therapy viral cell viral infections viral surface was selected yield [DOI] 10.1155/2022/7089576 PMC 바로가기 [Article Type] Article
Bean Extract-Based Gargle for Efficient Diagnosis of Active COVID-19 Infection Using Rapid Antigen Tests신속한 항원 테스트를 사용하여 활성 COVID-19 감염의 효율적인 진단을 위한 콩 추출물 기반 가글Research Article Published on 2022-02-162022-09-10 Journal: Microbiology Spectrum [Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료기술, [키워드] Ag-RDT Ag-RDTs Alpha alpha and delta variants alternative analyzed Antigen Asymptomatic Bean canavalin clinical trial Concentration COVID-19 COVID-19 cases COVID-19 patient COVID-19 patients Delta delta variant Delta variants Detachment Detection sensitivity diagnostic diagnostic test domain early diagnosis efficient ENhance evaluated Evidence gargle hACE2 healthy individual healthy individuals ingredient initial intermolecular interaction intermolecular interactions less management Mass screening Nasopharyngeal swab nasopharyngeal swabs noninvasive NPs oral virus Patient patients hospitalized Physicochemical properties Rapid Rapid diagnostic test RDTs RT-PCR saliva specimen saliva specimens salivary SARS-CoV-2 SARS-CoV-2 spike protein SARS-CoV-2 spike proteins SARS-CoV-2 variant screening process sensitivities sensitivity significantly Specificities specificity Spike proteins symptomatic symptomatic and asymptomatic Test tested the SARS-CoV-2 variants Viral Viral detection virus [DOI] 10.1128/spectrum.01614-21 PMC 바로가기 [Article Type] Research Article
VarEPS: an evaluation and prewarning system of known and virtual variations of SARS-CoV-2 genomesVarEPS: SARS-CoV-2 게놈의 알려진 가상 변이에 대한 평가 및 사전 경고 시스템AcademicSubjects/SCI00010 Published on 2022-01-072022-09-10 Journal: Nucleic Acids Research [Category] 변종, 진단, [키워드] ACE2 affinity Algorithm binding characteristic Classifier database drugs Effect Effectiveness Efficiency evaluate genomes genomic variation genomic variations Genomics MONITOR mutant strain Mutant strains Mutation Neutralizing antibodies Perspective Physicochemical properties provided reduced Research research and development resource risk SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 genomes SARS-CoV-2 variation secondary structure Spread structural biology translation Transmissibility unique Vaccine Vaccines Variation viral strain viral strains virulence was used [DOI] 10.1093/nar/gkab921 PMC 바로가기 [Article Type] AcademicSubjects/SCI00010
A Practical Strategy for Exploring the Pharmacological Mechanism of Luteolin Against COVID-19/Asthma Comorbidity: Findings of System Pharmacology and Bioinformatics AnalysisCOVID-19/천식 동반 질환에 대한 루테올린의 약리학적 메커니즘 탐색을 위한 실용적인 전략: 시스템 약리학 및 생물정보학 분석 결과Immunology Published on 2022-01-072022-09-11 Journal: Frontiers in Immunology [Category] 치료제, [키워드] activities Against AKT1 ALB Anti-inflammatory Antiviral approach Asthma binding binding activity Bioactivity Bioinformatics analysis biological activity Biological functions blood circulation Cancer Cell cell growth Comorbidity coronavirus disease Coronavirus disease 2019 COVID-19 Defense disease drug candidate Effect effective EGFR enrichment analysis ErbB evaluate Evidence experiments finding growth Health HIF-1 IL-6 immune regulation immune responses indicate indicated Inflammation Luteolin MAPK mechanism molecular docking analysis molecular mechanism oxidative stress pathway Patient PD-1 PD-L1 performed Pharmacology Physicochemical properties physicochemical property poor prognosis predicted Protein–protein interaction RAGE reducing Regulation Replication Research SARS-COV-2 infection Signaling Strategy suggested susceptibility System system pharmacology target targets TNF Toll-like receptor TP53 VEGFA virus [DOI] 10.3389/fimmu.2021.769011 PMC 바로가기 [Article Type] Immunology
Interaction of Spike protein and lipid membrane of SARS-CoV-2 with Ursodeoxycholic acid, an in-silico analysisArticle Published on 2021-11-152022-10-04 Journal: Scientific Reports [Category] MERS, SARS, 신약개발, [키워드] acid addition Alpha Analysis cholesterol Cluster Computational biology and bioinformatics decrease drug Drug development Dynamics evaluated exhibit form gallstone heptad repeat higher affinity host cell Hydrogen bond in-silico interact Interaction membrane membranes molecular docking monomer Numerous Physicochemical properties prefusion Protein protein sequences random reduce reduction in Region remained residue RMSD RMSF SARS-CoV-2 SARS-COV-2 infection severity shown spike tension the SARS-CoV-2 the Spike trajectory treat Ursodeoxycholic acid Viral hepatitis was performed [DOI] 10.1038/s41598-021-01705-5 PMC 바로가기 [Article Type] Article
Exposing structural variations in SARS-CoV-2 evolutionSARS-CoV-2 진화의 구조적 변이 노출Article Published on 2021-11-112022-09-10 Journal: Scientific Reports [Category] MERS, SARS, 변종, [키워드] ACE2 acute disease Affect affinity aligned Alpha Alpha variant Analysis B.1.1.7 B.1.617.2 conformational change conformations contributed coronavirus Course Critical delta variant disease effective Effectiveness Evolution function human cells integration lack Lineage Lineage B.1.1.7 Mutation mutations Physicochemical properties physicochemical property physiochemical property Protein protein sequence protein structure residue SARS-CoV SARS-CoV-2 SARS-CoV-2 evolution SARS-CoV-2 variants Spike protein Structural analysis structural biology Structural variation structural variations Structure structures the SARS-CoV-2 Vaccine variant Viral viral infection virus Virus evolution [DOI] 10.1038/s41598-021-01650-3 PMC 바로가기 [Article Type] Article
DeepImmuno: deep learning-empowered prediction and generation of immunogenic peptides for T-cell immunityDeepimmuno : T- 세포 면역을위한 면역 원성 펩티드의 딥 러닝에 대한 예측 및 생성Problem Solving Protocol Published on 2021-11-032022-09-10 Journal: Briefings in Bioinformatics [Category] MERS, SARS, 변종, [키워드] AdaBoost adaptive immune system addition Algorithms alleles Antigen antigen recognition antigens approach best binding Cancer Cancer immunotherapy Cell chose CNN computational method Computational methods conducted Convolutional neural network COVID-19 dataset datasets deep learning Dengue dengue virus distribution elicit FIVE foreign antigen foreign antigens forest GAN generative adversarial network human leukocyte antigen immunogenic peptide immunogenic potential immunogenicity Impact independent killing lack leukocyte life-threatening neoantigen Pathogens peptide peptides Physicochemical properties physicochemical property predict Random forest residual residue SARS-CoV-2 SARS-CoV-2 variants seeking sequence source code Support support vector machine T-cell T-cell immunity T-cell Response T-cells targeted therapy Vaccine [DOI] 10.1093/bib/bbab160 PMC 바로가기 [Article Type] Problem Solving Protocol