Capnodynamic monitoring of lung volume and blood flow in response to increased positive end-expiratory pressure in moderate to severe COVID-19 pneumonia: an observational studyObservational Study Published on 2022-07-312022-10-05 Journal: Critical Care [Category] 임상, [키워드] ANOVA arterial oxygen tension baseline blood flow breath changes in Confidence intervals correlated correlation correlation coefficient COVID-19 dead decrease Decreased demonstrated effective End-Expiratory Pressure facilitate feasibility fraction group increase in instantaneous less lung Lung perfusion Lung volume mean difference Mechanical mechanical ventilation mechanically ventilated patient moderate monitoring negative correlation non-responder non-responders outcome oxygen Oxygenation P/F P/F ratio Patient Pearson PEEP physiological physiological response Pneumonia Positive end-expiratory pressure positively correlated Primary outcome pulmonary blood flow recruited reported Respiratory failure Responder responders response secondary severe COVID-19 severe respiratory failure statistically to define Ventilation Volume was increased [DOI] 10.1186/s13054-022-04110-0 PMC 바로가기 [Article Type] Observational Study
Reduced fixed dose tocilizumab 400 mg IV compared to weight-based dosing in critically ill patients with COVID-19: A before-after cohort studyResearch article Published on 2022-07-012022-10-05 Journal: The Lancet Regional Health - Americas [Category] 바이오마커, [키워드] 28-day mortality assumed benefit Clinical outcome Cohort cohort study comparable cost-effectiveness Covid cytokine storm COVID-19 COVID-19 patient Critically ill Critically ill patient CRP demonstrated Dexamethasone dose equity family feasible finding fixed dose foundation funding groups Inflammation inhibitor interleukin-6 no significant difference pair-wise comparison Patient patients physiological response receiving reduce mortality reduction response Scholarship severe COVID-19 supported Taylor the patient threshold Tocilizumab treated with COVID-19 [DOI] 10.1016/j.lana.2022.100228 [Article Type] Research article
T Cells in Multisystem Inflammatory Syndrome in Children (MIS-C) Have a Predominant CD4+ T Helper Response to SARS-CoV-2 Peptides and Numerous Virus-Specific CD4- CD8- Double-Negative T Cells소아 다기관 염증 증후군(MIS-C)의 T 세포는 SARS-CoV-2 펩티드 및 수많은 바이러스 특이적 CD4-CD8- 이중 음성 T 세포에 대한 CD4+ T 도우미 반응이 우세합니다.Article Published on 2022-06-292022-09-11 Journal: International Journal of Molecular Sciences [Category] COVID19(2023년), SARS, 치료기술, [키워드] Activation Antigen CD3+ CD4 CD4+ CD4− CD8− double-negative T cells CD8 CD8+ CD8+ T cell CD8+ T cells children classical CTL Cytotoxic T cell enrolled epitope Epitopes example Follow-up frequencies helper immunodominant epitopes initial IQR lymphopenia magnitude majority MIS-C Numerous pathogenic Patient peptide peptide pool peptide pools peptides physiological response Protein Proteins Recognition recognize reported response SARS-CoV-2 SARS-CoV-2 peptide SARS-CoV-2 peptides SARS-CoV-2 spike SARS-CoV-2-specific T cell SARS-CoV-2-specific T cells single subject subject subjects subpopulation T cell T cell receptor T cell receptor Vβ21.3 T cell response T cell responses T cells T helper TCRs virus [DOI] 10.3390/ijms23137219 PMC 바로가기 [Article Type] Article
Bayesian network meta-analysis of face masks’ impact on human physiology안면 마스크가 인간 생리에 미치는 영향에 대한 베이지안 네트워크 메타 분석Meta-Analysis Published on 2022-04-062022-09-11 Journal: Scientific Reports [Category] COVID19(2023년), meta-analysis, SARS, [키워드] activity alteration Bayesian carbon dioxide clinically conditions criteria elevated exclusion exclusion criteria face Face mask Face masks facial greater heart rate human physiology hypercarbia Inclusion inclusion criteria increase in Mask Masks meta-analyses Meta-analysis Network meta-analysis overcome oxygen oxygen saturation oxygen uptake partial pressure Participants performed physiological response physiological responses PROSPERO public opinion Registered required Respirator respiratory Safe screened significant changes in slight increase subsequent Support surgical systematic review temperature Ventilation [DOI] 10.1038/s41598-022-09747-z PMC 바로가기 [Article Type] Meta-Analysis
Biological evaluation of a mechanical ventilator that operates by controlling an automated manual resuscitator. A descriptive study in swineResearch Article Published on 2022-03-032022-10-28 Journal: PLoS ONE [Category] Coronavirus, MERS, SARS, [키워드] addition alteration anaesthesia Analysis automated Biological blood biochemistry Brain carbonate Clinical studies condition detect eight electrocardiogram evaluate Evidence health system healthy histopathological in vivo kidney Lactate liver lung mechanical ventilation mechanical ventilator organ outbreak Oxygenation PaO parameter pathological finding performed physiological level physiological response preclinical data produced reported Support tissue tissue damage ventilatory parameters Volume [DOI] 10.1371/journal.pone.0264774 PMC 바로가기 [Article Type] Research Article
Effects of Face Masks on Physical Performance and Physiological Response during a Submaximal Bicycle Ergometer TestArticle Published on 2022-01-182022-10-29 Journal: International Journal of Environmental Research an [Category] Coronavirus, SARS, [키워드] Affect analyzed Bicycle blood pressure breathing frequency cardiorespiratory change changes in Community COVID-19 COVID-19 pandemic Effect effort Ergometer exhalation valve face Face mask Factor females Infection prevention investigated Likert scale males Mask Masks occupational health and safety oxygen participated Perceived performance peripheral capillary Personal protective equipment physical physical demand physical working capacity physiological physiological response protocol Randomized required response secondary Sex Side effect subject Test wearing face mask were measured [DOI] 10.3390/ijerph19031063 PMC 바로가기 [Article Type] Article
Alamandine: Potential Protective Effects in SARS-CoV-2 Patients알라만딘: SARS-CoV-2 환자의 잠재적인 보호 효과Review Published on 2021-11-082022-09-10 Journal: Journal of the Renin-Angiotensin-Aldosterone Syste [Category] MERS, 치료제, [키워드] ACE2 acute respiratory distress acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 alleviate angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 Anti-inflammatory anti-inflammatory properties antithrombogenic benefit Cardiomyopathy Characteristics coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 pathogenesis Effect fibrosis G protein-coupled receptor Health health benefits Hospitalization host cell host cells increase inhibit interstitial leads mortality rates occur outcome pathway pharmacological strategy physiological response Potential Prevent proinflammatory Protective pulmonary fibrosis RAS receptor reduce Renin renin-angiotensin system respiratory respiratory distress SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 patient severe acute respiratory syndrome Coronavirus severity Shock susceptibility systemic inflammatory thought Treatment upregulation [DOI] 10.1155/2021/6824259 PMC 바로가기 [Article Type] Review
Implementation of serological and molecular tools to inform COVID-19 patient management: protocol for the GENCOV prospective cohort studyCOVID-19 환자 관리를 알리는 혈청학적 및 분자적 도구의 구현: GENCOV 전향적 코호트 연구를 위한 프로토콜Article Published on 2021-09-302022-09-11 Journal: BMJ Open [Category] SARS, 변종, 진단, [키워드] Adult patients antibody Antibody Response antibody titres Antigen approved association B-cell baseline blood sample Blood samples Characteristics clinical Clinical data clinical trials Clinical Trials Ontario collected conducted correlated COVID-19 COVID-19 patient COVID-19 symptoms determine Diagnosis diagnostics disease severity Ethics evaluate genetic difference genetic differences genetic marker Genetic markers genetics Genome Genome sequencing genomic variant Greater Toronto Area hospitals Host host genome identify immune response immunology Infection information isotype leucocyte Lineage molecular molecular diagnostics Observational cohort study outcome outcomes participant Patient patients with COVID-19 peer-reviewed physiological response prospective cohort study protocol receiving receptor Regression regression models Research Research Ethics review SARS-COV-2 infection SARS-CoV-2 virus sequence information sequenced Sequencing serological severity severity of COVID-19 Symptom System T-cell the antibody response the SARS-CoV-2 virus Variability Viral viral genomes viral neutralisation virus genome [DOI] 10.1136/bmjopen-2021-052842 PMC 바로가기 [Article Type] Article
How Can Flowers and Their Colors Promote Individuals’ Physiological and Psychological States during the COVID-19 Lockdown?Article Published on 2021-09-292022-10-29 Journal: International Journal of Environmental Research an [Category] Coronavirus, SARS, [키워드] Affect affected Alpha average built environments Can color conducted COVID-19 COVID-19 isolation COVID-19 pandemic EEG EEGs Effect Electroencephalography evaluate expected experiment flower flower color Isolation mood normality parasympathetic participant Participants physiological physiological response positive profile Psychological psychological effect questionnaire responses restorative environments significantly significantly higher social distancing spread of COVID-19 state Stress the mean Variability Well-being were measured [DOI] 10.3390/ijerph181910258 PMC 바로가기 [Article Type] Article
Effect of prone positioning on oxygenation and static respiratory system compliance in COVID-19 ARDS vs. non-COVID ARDSResearch Published on 2021-08-062022-10-28 Journal: Respiratory Research [Category] COVID-19, MERS, [키워드] 1:1 95% CI acute respiratory distress acute respiratory distress syndrome adjusted analyzed ARDS association baseline change Clinical outcome clinically competing Compliance conditions COVID-19 Effect effective evaluated IQR mechanical ventilation not significant on mechanical ventilation Oxygenation PaO Patient patients with COVID-19 physiological effect physiological response Predictive prone Prone position prone positioning receiving Respiratory system Respiratory system compliance response Result risk static compliance subgroups of patient supplementary material syndrome therapeutic option treated while [DOI] 10.1186/s12931-021-01819-4 PMC 바로가기 [Article Type] Research