Analysis of complementarities between nanomedicine and phytodrugs for the treatment of malarial infectionArticle Published on 2023-10-312024-09-10 Journal: Nanomedicine (Lond) [Category] 말라리아, [키워드] Artemisinin-based combination therapy drug-delivery systems nanomedicine natural molecules Phytomedicine PMC 바로가기
Potential of cinnamaldehyde essential oil as a possible antimicrobial against fowl typhoid in layers계란을 낳는 닭의 장티푸스에 대한 가능한 항균제로서 시나말데하이드 에센셜 오일의 잠재력Article Published on 2023-03-212024-08-22 Journal: BMJ Clin Evid [Category] 살모넬라증, [키워드] Eggshell contamination Enterobacteriaceae fowl typhoid Phytomedicine Salmonella Gallinarum
Repurposing of phytomedicine-derived bioactive compounds with promising anti-SARS-CoV-2 potential: Molecular docking, MD simulation and drug-likeness/ADMET studiesResearch article Published on 2022-04-012022-10-05 Journal: Saudi Journal of Biological Sciences [Category] 신약개발, [키워드] active against anti-SARS-CoV-2 approach binding mode Compound computational method COVID-19 database docking Drug repurposing effective Efficacy Enzymes in silico inhibitor inhibitory effect initial management MD simulation molecular docking molecular dynamics Molecular dynamics simulation MPro notable phytochemicals Phytomedicine PLPro polymerase protease RdRP repurposing SARS-CoV-2 SARS-COV-2 infection screened selected steroid therapeutic target Toxicity [DOI] 10.1016/j.sjbs.2021.12.018 [Article Type] Research article
Antiviral and Immunomodulatory Effects of Pelargonium sidoides DC. Root Extract EPs® 7630 in SARS-CoV-2-Infected Human Lung CellsPharmacology Published on 2021-10-252022-10-31 Journal: Frontiers in Pharmacology [Category] COVID-19, [키워드] accompanied Affect Anti-inflammatory Antiviral antivirals assessment Calu-3 Calu-3 cell candidate CCL5 CD40L cell line cellular entry chemokine clinical study comparable Concentration coronavirus CoV COVID-19 COVID-19 therapeutics CXCL10 CXCL9 cytokine cytokine secretion Cytokine storm derivatives disease drug Duration of infection Effect elevated exhibited Extract fraction growth growth factor highly pathogenic Human human lung IC50 IL-13 IL-1β IL-6 IL-8 IL1B IL6 immune immunomodulatory function immunomodulatory properties in vitro in vivo Inflammatory response inhibited inhibiting innate immune response MERS-CoV modulation non-toxic oligomerization Particle PDGF Pelargonium pelargonium root extract (EPs® 7630) Phytomedicine Post-infection pro-inflammatory cytokine pro-inflammatory gene Prodelphinidin pseudovirus purine reduced reducing Regulation root SARS-CoV SARS-CoV-2 SARS-CoV-2 entry SARS-CoV-2 propagation separated shown significantly symptom severity TNF-α TNFAIP3 upper respiratory upregulation Viral load viruses [DOI] 10.3389/fphar.2021.757666 PMC 바로가기 [Article Type] Pharmacology
Traditional Herbal Medicines, Bioactive Metabolites, and Plant Products Against COVID-19: Update on Clinical Trials and Mechanism of ActionsPharmacology Published on 2021-05-282022-10-31 Journal: Frontiers in Pharmacology [Category] COVID-19, [키워드] Action affecting Against Anti-COVID-19 Anti-infective anticancer therapies Antiviral antiviral properties approach approved Ayurved medicine bioactive metabolites clinical clinical trial conducted coronavirus COVID-19 develop drugs effective Efficacy eliminated global public health Herbal Hospitalization identify infective medications Medicine Medicines metabolite morbidity and mortality notable nutraceuticals pandemic phytochemicals Phytomedicine plant product reached researcher SARS-CoV-2 shown therapy Traditional Traditional Chinese medicine traditional Chinese medicines Vaccine Vaccines viral infection World Health Organization worldwide pandemic [DOI] 10.3389/fphar.2021.671498 PMC 바로가기 [Article Type] Pharmacology
Perspectives on plant flavonoid quercetin-based drugs for novel SARS-CoV-2Review Published on 2021-03-242022-10-28 Journal: Beni-Suef University Journal of Basic and Applied Sciences [Category] COVID-19, [키워드] 3CL pro 3CLpro 3D structure Abstract Ala Antiviral antiviral activities antiviral activity antiviral property binding energy caused Combination complex COVID-19 derivative deubiquitinase docked docking drug drug candidate drug design enzyme Enzymes flavonoid inhibiting interactions involved miRNA Mol molecular mechanism N-terminus Novel coronavirus pandemic Papain-like protease pathway Phytomedicine predicted proof Protein provided quercetin Regulation residue RNA RNA binding protein RNA-dependent RNA polymerase SARS-CoV-2 SARS-CoV-2 main protease shown spike glycoprotein Treatment viral pathogenesis Virtual screening viruses Zinc [DOI] 10.1186/s43088-021-00107-w PMC 바로가기 [Article Type] Review
Antiviral Activity of Jamaican Medicinal Plants and Isolated Bioactive CompoundsReview Published on 2021-01-252022-10-30 Journal: Molecules [Category] COVID-19, [키워드] activity acute respiratory syndrome African antiviral activity antivirals Asian cancers caused Compound coronavirus country Diseases disorder drugs estimate Hepatitis HIV-1 HIV-2 Human immunodeficiency virus Infection influenza A virus Isolated Jamaica Medicine microbial infections Pain phytoantiviral Phytomedicine plant plants profile reproductive Research SARS CoV-2 Side-effect treat viral infections virus WHO World Health Organization [DOI] 10.3390/molecules26030607 PMC 바로가기 [Article Type] Review
The Relevance of Complementary and Integrative Medicine in the COVID-19 Pandemic: A Qualitative Review of the LiteratureMedicine Published on 2020-12-112022-10-31 Journal: Frontiers in Medicine [Category] COVID-19, [키워드] analyzed approach benefit botanicals clinical evidence clinical parameter Clinicians collected data complementary medicine compounds condition conducted Course COVID-19 COVID-19 pandemic Effect Effects Evidence General population Health hypertension identify immune function include Influenza integrative medicine limitations literature literature review measure Measures Medicine Mental mental health micronutrients mind-body medicine obesity offer pandemic patients physical physical activity Phytomedicine Qualitative quarantine reduced Relevance Research Resilience Respiratory tract infections review risk risk factor SARS-CoV-2 selected Self-isolation social contact starting point therapeutic therapeutic option Topic traditional medicine systems variety while [DOI] 10.3389/fmed.2020.587749 PMC 바로가기 [Article Type] Medicine
Exploring nature’s bounty: identification of Withania somnifera as a promising source of therapeutic agents against COVID-19 by virtual screening and in silico evaluationResearch Article Published on 2020-11-272023-06-15 Journal: Journal of biomolecular structure & dynamics [Category] MERS, SARS, [키워드] molecular chemoinformatics molecular docking Phytomedicine SARS-CoV-2 target proteins Withanolides [DOI] 10.1080/07391102.2020.1835725 PMC 바로가기 [Article Type] Research Article
Plants-Derived Biomolecules as Potent Antiviral Phytomedicines: New Insights on Ethnobotanical Evidences against CoronavirusesReview Published on 2020-09-212022-10-28 Journal: Plants [Category] COVID-19, [키워드] 3CLpro ACE-2 receptor Analysis Antiviral antiviral activity Antiviral compound antiviral property bioactive compounds Biomolecule Combination Compound coronavirus Coronaviruses correlation COVID-19 Critical develop drugs effective Efficacy ethnobotany Evidence human diseases increased mortality insight medicinal plant MERS-CoV metabolites natural products New pandemic disease Phytomedicine plant plants potent protocol researcher Safe SARS-CoV SARS-CoV-1 SARS-COV-2 infection targets therapeutic therapeutic agent Vaccine Viral protein [DOI] 10.3390/plants9091244 PMC 바로가기 [Article Type] Review