A multicenter, double-blind, randomized, parallel-group, placebo-controlled study to evaluate the efficacy and safety of camostat mesilate in patients with COVID-19 (CANDLE study)Article Published on 2022-09-272022-11-15 Journal: BMC Medicine [Category] SARS, 진단, [키워드] 95% confidence interval Administered age airway Analysis asymptomatic patients Bayesian camostat camostat mesilate cardiovascular diseases cells Chronic kidney disease chronic respiratory disease clinical conducted consecutive negative test conversion COVID-19 COVID-19 symptom Diabetes Mellitus dose double-blind Drug screening effective Efficacy and safety eight enrolled evaluate Factor first test hospital human airway epithelial hypertension indicated Japan median time Mild moderate multicenter no significant difference obesity parallel-group Patient patients patients with COVID-19 Placebo placebo-controlled study Positive test Prevent primary efficacy endpoint Randomized Randomized controlled trial receive reduce registry SARS-CoV-2 SARS-COV-2 infection the placebo group the primary endpoint Treatment two groups underlying disease viral clearance viral loads was performed were blinded were excluded without symptoms [DOI] 10.1186/s12916-022-02518-7 PMC 바로가기
Efficacy of individualized homeopathy as an adjunct to standard of care of COVID-19: A randomized, single-blind, placebo-controlled studyRandomized Controlled Trial Published on 2022-08-012022-10-05 Journal: Complementary therapies in clinical practice [Category] 신약개발, 임상, [키워드] placebo-controlled study Randomized single-blind Standard of care [DOI] 10.1016/j.ctcp.2022.101602 PMC 바로가기 [Article Type] Randomized Controlled Trial
A randomized, placebo-controlled clinical trial evaluating of a mouthwash containing Sambucus williamsii var. coreana extract for prevention of gingivitits Research Published on 2022-07-182022-10-05 Journal: Scientific Reports [Category] 임상, [키워드] applicability assigned Bacteria Care carried conducted Day disease double-blind effective experiment Health healthy homogeneity IBM inhibiting maintain participant patients placebo-controlled clinical trial placebo-controlled study plaque plaques progression Randomized saline solution Sambucus shown significant difference SPSS 24.0 study period two groups USA using a mouthwash VAR was used window [DOI] 10.1038/s41598-022-15445-7 [Article Type] Research
Influence on study outcomes of an inpatient study by the behavior of the study staff (PINgPOng): study protocol for a randomized clinical trial연구 직원의 행동이 입원 환자 연구의 연구 결과에 미치는 영향(PINGPOng): 무작위 임상 시험을 위한 연구 프로토콜Article Published on 2022-06-132022-09-11 Journal: Trials [Category] COVID19(2023년), SARS, 임상, [키워드] administration Affect Alpha amylase analgesic Analgesic therapy analyzed Anxiety Behavior characteristic classical clinical clinical development clinical study clinical trial cold pressor test conducted cortisol covariate covariates cross-over Declaration of Helsinki Depression double-blind Drug efficacy Effect Effects Factor fixed healthy volunteer help Helsinki ICH-GCP influence intensity Neutral Oxycodone Pain pain intensity pharmacological phase Placebo Placebo effect Placebo response placebo-controlled study pressor test primary endpoint question Randomized randomized clinical trial RCT RCTs reaction response responses salivary single-center specific effect specific effects Stress study outcome Study protocol Study team. Symptom tested treated Treatment university [DOI] 10.1186/s13063-022-06436-0 PMC 바로가기 [Article Type] Article
Probiotics for Reduction of Examination Stress in Students (PRESS) study: A randomized, double-blind, placebo-controlled trial of the probiotic Lacticaseibacillus rhamnosus HN001Randomized Controlled Trial Published on 2022-06-082022-10-05 Journal: PLoS ONE [Category] 임상, [키워드] Anxiety baseline benefit Compound COVID19 determine double-blind Evidence examination Factor groups highlight human population IMPROVE Intervention measure no significant difference outcomes pandemic Placebo placebo-controlled study placebo-controlled trial post-intervention Probiotics Psychological psychological health Psychological outcome Randomized reduced Stress student supplemented group trajectory Trial [DOI] 10.1371/journal.pone.0267778 PMC 바로가기 [Article Type] Randomized Controlled Trial
Efficacy and safety of intramuscular administration of tixagevimab–cilgavimab for early outpatient treatment of COVID-19 (TACKLE): a phase 3, randomised, double-blind, placebo-controlled trialClinical Trial Published on 2022-06-072022-10-05 Journal: The Lancet. Respiratory Medicine [Category] COVID19(2023년), SARS, 임상, 진단, 치료법, 치료제, [키워드] 1:1 95% CI administration Adverse age Antigen assigned AstraZeneca block sizes blocked clinical clinical evaluation clinically collected conducted Course COVID-19 COVID-19 vaccination death dose double-blind Efficacy enrolled enrolment Europe evaluate event Fever finding for inclusion funding individual intramuscular intramuscular injections investigators involved Japan laboratory-confirmed SARS-CoV-2 infection Latin America less Mild moderate Moderate COVID-19 monoclonal antibody combination non-hospitalised occurred Older outcomes participant Phase 3 Placebo placebo-controlled study placebo-controlled trial prevent disease progression primary endpoint progression provided randomisation randomised Randomly receive Registered required respiratory tract risk reduction RT-PCR scale severe COVID-19 severity specimen Sponsor statistically stratified study drug Symptom symptom onset the disease the placebo group treating Treatment treatment group USA WHO [DOI] 10.1016/S2213-2600(22)00180-1 [Article Type] Clinical Trial
Efficacy, safety, and immunogenicity of the DNA SARS-CoV-2 vaccine (ZyCoV-D): the interim efficacy results of a phase 3, randomised, double-blind, placebo-controlled study in IndiaClinical Trial Published on 2022-04-022022-10-05 Journal: Lancet (London, England) [Category] COVID19(2023년), SARS, 임상, [키워드] 1:1 95% CI Administered adverse event Analysis assessment assigned baseline Biotechnology clinical clinical trial comorbid conditions conducted COVID-19 criteria Cutoff death Department DNA dose double-blind Efficacy efficacy analysis eligible enrolled Government of India Gujarat identify immunogenic India individual injection interim analysis investigators multicentre Occurrence Older outcome assessor participant per-protocol population Phase 3 phase 3 trial Placebo placebo group placebo-controlled placebo-controlled study Primary outcome randomisation randomised Randomly receive Registered registry reported Safe safety population SARS-CoV-2 SARS-CoV-2 vaccine screened symptomatic the placebo group Tolerability Treatment treatment group Trial Vaccine was done was used [DOI] 10.1016/S0140-6736(22)00151-9 PMC 바로가기 [Article Type] Clinical Trial
A phase 1/2 randomised placebo-controlled study of the COVID-19 vaccine mRNA-1273 in healthy Japanese adults: An interim report건강한 일본 성인을 대상으로 한 코로나19 백신 mRNA-1273의 1/2상 무작위 위약 대조 연구: 중간 보고서Clinical Trial Published on 2022-03-182022-09-12 Journal: Vaccine [Category] COVID19(2023년), MERS, SARS, 임상, 진단, [키워드] 95% CI 95% confidence interval acute respiratory syndrome Administered adverse event AEs age AMED anti-SARS-CoV-2 immune response antibody ARMS baseline company conducted coronavirus COVID-19 COVID-19 vaccine mRNA-1273 demonstrated development dose ENCODE enrolled fatigue geometric healthy immune response immunogenicity Injection-site pain Interim report Intramuscular injection Japan Japanese Limited mRNA vaccine mRNA-1273 myalgia NAb neutralising antibody occurred outcome participant Participants pharmaceutical Placebo placebo-controlled study placebo-controlled trial randomised receive reported Safety safety profile SARS-CoV-2 SARS-COV-2 infection secondary outcome Spike protein stratified Takeda vaccination Vaccine [DOI] 10.1016/j.vaccine.2022.02.030 PMC 바로가기 [Article Type] Clinical Trial
A Multi-Center, Randomised, Double-Blind, Placebo-Controlled Phase III Clinical Trial Evaluating the Impact of BCG Re-Vaccination on the Incidence and Severity of SARS-CoV-2 Infections among Symptomatic Healthcare Professionals during the COVID-19 Pandemic in Poland—First ResultsArticle Published on 2022-02-172022-10-28 Journal: Vaccines [Category] COVID-19, [키워드] 1:1 All participant Bacillus BCG BCG vaccination clinical clinical trial conducted control group coronavirus disease correlation country Course COVID-19 Diseases double-blind Evaluating Frequency Health care Health care worker hypothesised immune response Impact incidence incidence of COVID-19 introduced lack multicenter non-specific observation occurrence of COVID-19 pandemic phase Placebo placebo-controlled study Poland Prevent professional randomised reduce Research Result SARS-CoV-2 shown statistical analysis statistically significant stimulate Symptoms the disease Trial vaccination Vaccine Vaccines World Health Organization [DOI] 10.3390/vaccines10020314 PMC 바로가기 [Article Type] Article
Molecular Hydrogen Positively Affects Physical and Respiratory Function in Acute Post-COVID-19 Patients: A New Perspective in RehabilitationRandomized Controlled Trial Published on 2022-02-102022-10-04 Journal: International Journal of Environmental Research an [Category] COVID19(2023년), MERS, SARS, 임상, [키워드] 6-min walking test Anti-inflammatory Antioxidative approach COVID-19 determine disease Effect effective experiment expiratory fatigue female function FVC Health hydrogen hydrogen inhalation male Molecular hydrogen New oxygen saturation participant Patient performed physical Placebo placebo-controlled study polymerase chain positive Post-COVID-19 patients Pulmonary function Pulmonary function test Randomized recruited respiratory Respiratory function Result Safe significantly increased single-blind therapeutic therapy Volume [DOI] 10.3390/ijerph19041992 PMC 바로가기 [Article Type] Randomized Controlled Trial