Development and Validation of a Plaque Assay to Determine the Titer of a Recombinant Live-Attenuated Viral Vaccine for SARS-CoV-2Article Published on 2024-04-012024-09-05 Journal: Vaccines [Category] update2024, [키워드] COVID-19 pfu Plaque assay SARS-CoV-2 Vaccine validation [DOI] 10.3390/vaccines12040374 PMC 바로가기 [Article Type] Article
Invasion of HeLa Cells by Shigella Species Clinical Isolates Recovered from Pediatric Diarrheaarticle Published on 2023-11-302024-09-01 Journal: Foodborne Pathogens and Disease [Category] 세균성이질, [키워드] Antibiotic resistance HeLa cell pediatrics Plaque assay Shigella virulence factors [Article Type] article
Comparative characterization of Crimean-Congo hemorrhagic fever virus cell culture systems with application to propagation and titration methodsarticle Published on 2023-06-192024-09-05 Journal: Virology Journal [Category] update2024, [키워드] BSR-T7/5 Cell culture cell line Crimean-Congo hemorrhagic fever virus Huh-7 Plaque assay SW-13 TCID50 titration Vero E6 [DOI] 10.1186/s12985-023-02089-w PMC 바로가기 [Article Type] article
SARS-CoV-2 coinfection in immunocompromised host leads to the generation of recombinant strainArticle Published on 2023-03-152024-09-05 Journal: International Journal of Infectious Diseases [Category] update2024, [키워드] Co-infection Plaque assay Recombinant XS SARS-CoV-2 variants Whole genome sequencing [DOI] 10.1016/j.ijid.2023.03.014 PMC 바로가기 [Article Type] Article
The Integral Membrane Protein ZMPSTE24 Protects Cells from SARS-CoV-2 Spike-Mediated Pseudovirus Infection and Syncytia FormationArticle Published on 2022-10-262022-11-15 Journal: mBio [Category] COVID19(2023년), SARS, 유전자 메커니즘, 치료제, [키워드] acute respiratory syndrome appear assays catalytic caused Cell cell-cell fusion cell-cell fusion assay cells cellular cellular component cellular membrane contribute coronavirus coronavirus SARS-CoV-2 Coronaviruses COVID-19 COVID-19 pandemic dead defend Defense Efficiency ENhance entry of SARS-CoV-2 examined Formation genetic knockout global public health host cell membranes IFITM IFITMs in viral include Infection inhibiting inhibitory activity innate immune innate immune response Integral interact Interaction interfere intrinsic knockdown lentivirus maturation mechanism membrane membrane protein MHV mouse hepatitis virus nuclear overexpression pandemic Plaque assay precursor prelamin A Prevent protease Proteases PROTECT Protective protective role Protein proteolytic proteolytic activity reduce required restriction factor restriction factor. SARS-CoV-2 SARS-CoV-2 pseudovirus infection shown spike Therapeutic benefit transmembrane protein viral infection viral infections virus virus entry viruses wild-type ZMPSTE24 [DOI] 10.1128/mbio.02543-22 PMC 바로가기
Low molecular weight chitooligosaccharide inhibits infection of SARS-CoV-2 in vitro저분자량 키토올리고당은 시험관 내에서 SARS-CoV-2의 감염을 억제합니다Article Published on 2022-08-012022-09-11 Journal: Journal of Applied Microbiology [Category] COVID19(2023년), SARS, 치료법, 치료제, [키워드] Analysis Antiviral Antiviral effect antiviral effects candidate chitooligosaccharide chitosan COVID-19 cytotoxicity dose-dependent manner Drug development E gene fluorescence intensity gel in vitro infected cells Infection inhibit low molecular weight molecular weight MTT natural antiviral natural treatment. permeation Plaque assay Protein Quantitative RdRP respond SARS-CoV-2 SARS-CoV-2 nucleocapsid SARS-CoV-2 virus Significance suggested tested the SARS-CoV-2 virus Treatment Vero cells Viral RNA virus-infected cell virus-infected cells was measured [DOI] 10.1111/jam.15618 PMC 바로가기 [Article Type] Article
Enoxaparin augments alpha-1-antitrypsin inhibition of TMPRSS2, a promising drug combination against COVID-19Enoxaparin은 COVID-19에 대한 유망한 약물 조합인 TMPRSS2의 알파-1-항트립신 억제를 증가시킵니다.Article Published on 2022-03-252022-09-11 Journal: Scientific Reports [Category] SARS, 변종, 진단, 치료법, [키워드] affected alpha-1-antitrypsin anti-inflammatory activity antitrypsin Cell cells cleave complex consequence Coronavirus infection COVID-19 crystal structure drug combination ENhance enoxaparin epithelial cell epithelial cells hAEC HCoV HCoV-229E HEK293T cell HEK293T cells heparin human coronavirus human coronavirus 229E immunostaining Infection Inflammatory less molecular nafamostat Neutralizing nucleocapsid protein overexpressing Plaque assay primary human airway Primary human airway epithelial cells quantified reactive required SARS-CoV-2 SARS-CoV-2 mutations Serine serine protease severe COVID-19 Spike protein the cell the spike protein therapy TMPRSS2 TMPRSS2 inhibitor Treatment Viral viral entry virus was determined [DOI] 10.1038/s41598-022-09133-9 PMC 바로가기 [Article Type] Article
Early reduction of SARS-CoV-2-replication in bronchial epithelium by kinin B 2 receptor antagonism키닌 B 2 수용체 길항작용에 의한 기관지 상피의 SARS-CoV-2 복제의 조기 감소Original Article Published on 2022-03-052022-09-10 Journal: Journal of Molecular Medicine (Berlin, Germany) [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] ACE2 ACE2 receptor airway airway epithelial cell airway epithelial cells Airway inflammation Analysis analyzed antagonism antagonist antagonists approved assays B2R-antagonist Bronchial epithelium cellular clinical study complex controls COVID-19 Critical cytotoxicity early-stage COVID-19 entry receptor epithelial epithelial cells Evidence Ex vivo expression of SARS-CoV-2 Future G protein Host Icatibant immune regulation in vitro in vivo in vivo model induction Infection information inhibiting inhibiting viral replication Interference Kallikrein Kinin Kinin-kallikrein-system mechanism murine nasal nasal mucosa negative nose pathway performed Plaque assay plaque assays PROTECT protection provide receptor receptor signaling reduce reduced reduction Replication RT-qPCR SARS-CoV-2 SARS-CoV-2 entry receptor SARS-CoV-2 replication SARS-CoV-2 RNA SARS-CoV-2-positive patients Signaling Spread study participant Study participants supplementary material symptomatic Transcriptome transcriptomes translational Transport treated Treatment upregulation Vero-E6 cells Viral viral replication were infected [DOI] 10.1007/s00109-022-02182-7 PMC 바로가기 [Article Type] Original Article
Viral load of SARS-CoV-2 in droplets and bioaerosols directly captured during breathing, speaking and coughingArticle Published on 2022-03-032022-10-29 Journal: Scientific Reports [Category] COVID-19, SARS, [키워드] acid activity average coughing cycle threshold Determining droplet expiratory Factor identify indicated individual Infectious diseases Infectious virus macroscopic NP swab outcome Plaque assay positively correlated public health Respiratory droplets retrieved risk RNA SARS-CoV-2 SARS-CoV-2 RNA secretion standardized protocol Swab Transmission viral infection Viral load [DOI] 10.1038/s41598-022-07301-5 PMC 바로가기 [Article Type] Article
Naïve Human Macrophages Are Refractory to SARS-CoV-2 Infection and Exhibit a Modest Inflammatory Response Early in InfectionArticle Published on 2022-02-212022-10-28 Journal: Viruses [Category] COVID-19, COVID19(2023년), Fulltext, SARS, 신종인플루엔자, [키워드] absence acute respiratory distress ARDS COVID-19 patients cytokine cytokine level cytokine response Cytokine storm Cytokines driven by excessive secretion expression external gene Factor H1N1 H5N1 Heterologous highly pathogenic Human human monocyte-derived macrophage hyperinflammation IFN-α IFN-β Infectivity Influenza Influenza virus influenza viruses Involvement M gene Macrophage macrophages MDM notable pathogenic Plaque assay Proinflammatory cytokine proteome qRT-PCR refractory replicated Replication response SARS-CoV-2 SARS-COV-2 infection semiquantitatively stimulated susceptible syndrome TCID virus were assessed [DOI] 10.3390/v14020441 PMC 바로가기 [Article Type] Article