High Prevalence of Undocumented SARS-CoV-2 Infections in the Pediatric Population of the Tyrolean District of SchwazArticle Published on 2022-10-192022-11-15 Journal: Viruses [Category] COVID19(2023년), SARS, 진단, [키워드] Adding age anti-nucleocapsid antibody Anti-spike anti-spike antibody binding children collected confirmed cases District durable immune response household contacts humoral Humoral response immune Infection Neutralizing neutralizing antibody participated PCR-confirmed pediatric pediatric infection plasma sample Population Prevalence proportion provided questionnaire reported SARS-CoV-2 SARS-COV-2 infection Seroprevalence silent study participant Symptom translated Transmission unreported infection. vaccination [DOI] 10.3390/v14102294 PMC 바로가기
Levels of soluble complement regulators predict severity of COVID-19 symptomsArticle Published on 2022-10-182022-11-16 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 변종, [키워드] analysed Analysis approach Asymptomatic baseline level Biomarkers cascade circulating Cohort complement Control Course COVID-19 COVID-19 patients Diagnosis disease disease severity driving dysregulation Elevation Evidence Factor Factor H factor H-related proteins FIVE Healthcare systems hospitalisation Hypothesis immune activation individual lack Level majority management mass spectrometry Mild morbidity and mortality outcome outcomes Patient plasma sample predict Protein Proteins quantified responsible SARS-CoV-2 SARS-CoV-2 patient SARS-CoV-2 virus severe COVID-19 severe disease severity of COVID-19 splice subset Support Symptom variant while with COVID-19 [DOI] 10.3389/fimmu.2022.1032331 PMC 바로가기
Neutralization effect of plasma from vaccinated COVID-19 convalescents on SARS-CoV-2 Omicron variantsArticle Published on 2022-09-292022-11-15 Journal: Frontiers in Immunology [Category] SARS, 변종, 진단, [키워드] average B.1.1.529 B.1.617.2 caused convalescent convalescent COVID-19 patients convalescent individual convalescent individuals coronavirus COVID-19 death Delta delta variant determine escaped global pandemic Infection neutralization neutralization activity neutralize Neutralizing activity Neutralizing antibodies not neutralize not significant omicron Patient performed plasma plasma sample pre-vaccination Pseudovirus neutralization assay raise reduction replaced reported SARS-CoV-2 sera shown significant difference significantly three groups Vaccine variant [DOI] 10.3389/fimmu.2022.975533 PMC 바로가기
Humoral response and neutralising capacity at 6 months post-vaccination against COVID-19 among institutionalised older adults in ArgentinaArticle Published on 2022-09-262022-11-15 Journal: Frontiers in Immunology [Category] SARS, 진단, [키워드] affected age aging adults Anti-spike anti-Spike IgG antibody AZD1222 B.1 BBIBP-CorV Buenos Aires Cohort Complete correlation COVID-19 COVID-19 pandemic death different time point dose elicited evaluated Evidence evidenced exhibited Gender highlighting hospitalisation humoral Humoral response IgG titer IgG titers initial management neutralising Neutralising activity Neutralising Antibodies neutralising antibodies. Older omicron pandemic participant Participants plasma sample platform provide public health resulting SARS-CoV-2 significantly higher Sputnik-V Strong vaccination vaccination schedule vaccine platform Volunteer [DOI] 10.3389/fimmu.2022.992370 PMC 바로가기
Plasma SARS-CoV-2 nucleocapsid antigen levels are associated with progression to severe disease in hospitalized COVID-19Article Published on 2022-09-142022-11-15 Journal: Critical Care [Category] SARS, 치료기술, [키워드] 95% CI adjusted Antigen association AUROC baseline Clinical deterioration Clinical outcome clinical outcomes clinical status Coagulation collected Concentration correlated correlation correlations Course COVID-19 Cutoff death detectable Enrollment Hospital admission hospitalized COVID-19 hospitalized patient host response ICU admission IL-10 IMPROVE In-hospital increase in Inflammation IP-10 marker mechanical ventilation Multiple multiple logistic regression N-antigen Negative predictive value Pathogenesis Patient plasma plasma biomarker plasma concentration plasma sample Positive predictive value Primary outcome Prognosis prognostic progression prospective observational cohort RAGE risk stratification SARS-CoV-2 SARS-CoV-2 N-antigen SARS-CoV-2 nucleocapsid secondary outcome severe disease significantly Study participants subject tested tissue damage unlikely upper respiratory tract Viral antigen Viral RNA was used were assessed were measured WHO WHO ordinal scale with COVID-19 World Health Organization [DOI] 10.1186/s13054-022-04153-3 PMC 바로가기
TNFRSF1B and TNF Variants Are Associated With Differences in Levels of Soluble Tumor Necrosis Factor Receptors in Patients With Severe COVID-19Article Published on 2022-09-132022-11-16 Journal: The Journal of Infectious Diseases [Category] 변종, [키워드] association coronavirus disease COVID-19 COVID-19 severity determine difference ELISA evaluated exhibited expression Factor genetic study Genetic variant genetic variants genetics Genotype genotypes implicated IMV Invasive mechanical ventilation Level no difference paO2/fiO2 Patient patients patients with COVID-19 plasma plasma sample receptor severe COVID-19 severity TNF TNF-α TNFR1 TNFR2 TNFRSF1A TNFRSF1B Tumor tumor necrosis factor-α variant was used were used with COVID-19 [DOI] 10.1093/infdis/jiac101 PMC 바로가기
ORF8 protein of SARS-CoV-2 reduces male fertility in miceSARS-CoV-2의 ORF8 단백질은 쥐의 수컷 생식력을 감소시킵니다Article Published on 2022-09-012022-09-11 Journal: Journal of medical virology [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, [키워드] abnormality accompanied acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Administered Analysis Antibody titer Antibody titers Betacoronavirus body weight can be used circulating Col1a1 convalescent patient coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 cultured cells decreased expression dependent on Endoplasmic reticulum examined Food Intake Gene Expression genus genus Betacoronavirus Human in vivo indicated Infection infertility inhibited inhibitor injection male mice Morphological N-terminal observation Open reading frame open reading frames ORF8 ORF8 protein oxygen peptide peptide sequence plasma sample plasma samples Protein provide reactive oxygen specy reduce reproductive reproductive system respiratory SARS-CoV-2 secretion sequence severe acute respiratory syndrome Coronavirus signal peptide testes the patient translated vitality [DOI] 10.1002/jmv.27855 PMC 바로가기 [Article Type] Article
Development of a multiomics model for identification of predictive biomarkers for COVID-19 severity: a retrospective cohort studyResearch article Published on 2022-09-012022-10-05 Journal: International Journal of Environmental Research an [Category] COVID19(2023년), SARS, 바이오마커, 유전자 메커니즘, 진단, [키워드] absence adverse outcomes analysed approach assigned Biomarker Biomarkers Classifier CLEC6A Clinical improvement Clinical outcome Clinical use Cohort cohorts collected complex complications Course COVID-19 COVID-19 pandemic Critical cytokine Cytokines dataset defined development disease disease severity disorder domain Eric ether example finding funding high variability hospital Hospital admission independent Lipid lipids machine Machine learning algorithms marker Mayo Clinic metabolite metabolites molecular MOST multidimensional outcome participant Patient patients with COVID-19 plasma plasma sample positive predict predicted Predictive producing Protein Proteins proteomics proximity extension assay quantified reported representing retrospective cohort study SARS-CoV-2 RT-PCR severity subgroup subset Tandem mass spectrometry the WHO USA was done with COVID-19 [DOI] 10.1016/S2589-7500(22)00112-1 [Article Type] Research article
Host Predictors of Broadly Cross-Reactive Antibodies Against Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Variants of Concern Differ Between Infection and Vaccination중증 급성 호흡기 증후군 코로나바이러스 2(SARS-CoV-2)에 대한 광범위한 교차 반응성 항체의 숙주 예측 인자는 감염과 예방 접종 사이에 차이가 있습니다.Observational Study Published on 2022-08-242022-09-11 Journal: Clinical Infectious Diseases: An Official Publicat [Category] SARS, 변종, 임상, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Against antibody Antibody Response B.1.1.7 B.1.351 B.1.617.2 BMI booster Clinical characteristics clinician Clinicians Cohort collected concern contributed coronavirus coronavirus 2 cross-reactive cross-reactive antibodies cross-reactive antibody disease severity enzyme enzyme-linked immunosorbent enzyme-linked immunosorbent assay Factor Health healthy highest Host identify IgG IgG antibodies IgG antibody IgG level immunization Immunocompromised Immunoglobulin Immunoglobulin G individual Infection information metabolic health mounted mRNA vaccination P.1 participant plasma sample plasma samples Population populations predict prospective observational cohort Protective Protective antibody RBD Receptor binding domain Regression model regression models researchers respiratory responses SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 variant severe acute respiratory syndrome Coronavirus Spike receptor binding domain tested These data vaccination Vaccine Variability variants variants of concern Viral Viral variants virus variants Wuhan younger people [DOI] 10.1093/cid/ciab996 PMC 바로가기 [Article Type] Observational Study
Unbiased discovery of autoantibodies associated with severe COVID-19 via genome-scale self-assembled DNA-barcoded protein libraries Research Published on 2022-08-192022-10-05 Journal: Nature biomedical engineering [Category] 임상, 치료기술, 치료법, [키워드] addition Analysis autoantibody autoreactive antibody can be used circulating convalescent plasma COVID-19 detect DNA expressed facilitate FIVE full-length protein healthy IFN IFN-α individuals with COVID-19 interactions interferon life-threatening life-threatening coronavirus disease Neutralizing ORFeome Patient plasma plasma sample plasma samples Protein Sequencing severe COVID-19 unique [DOI] 10.1038/s41551-022-00925-y [Article Type] Research