RNAseq of INOCA patients identifies innate, invariant, and acquired immune changes: potential autoimmune microvascular dysfunctionCardiovascular Medicine Original Research Published on 2024-06-242024-09-05 Journal: Frontiers in Cardiovascular Medicine [Category] update2024, [키워드] Coronary artery disease INOCA invasive coronary angiography (ICA) MAIT (mucosal-associated invariant T) cell neutrophil plasmacytoid dendritic cell RNAseq T cell [DOI] 10.3389/fcvm.2024.1385457 PMC 바로가기 [Article Type] Cardiovascular Medicine Original Research
Macrophage phagocytosis of SARS-CoV-2-infected cells mediates potent plasmacytoid dendritic cell activationarticle Published on 2023-05-302024-09-05 Journal: Cellular & molecular immunology [Category] update2024, [키워드] dendritic cells Inflammatory cytokines Innate immunity Interferon-α Monocyte-derived macrophages phagocytes plasmacytoid dendritic cell SARS-CoV-2; COVID-19 [DOI] 10.1038/s41423-023-01039-4 PMC 바로가기 [Article Type] article
Correlation between Type I Interferon Associated Factors and COVID-19 SeverityArticle Published on 2022-09-192022-11-15 Journal: International Journal of Molecular Sciences [Category] SARS, 치료제, [키워드] acute respiratory syndrome Adaptive immune response Affect Antiviral antiviral response caused cells Chronic diseases conditions coronavirus COVID-19 COVID-19 severity declined dendritic cell dysfunction dysregulation early phase Factor Factors Frequency IFN IFN response IFN signature increased risk individual individual immune response inhibit magnitude Mild no symptoms Patient plasmacytoid dendritic cell plasmacytoid dendritic cell 1 Prevent produced producing promote response responsible risk risk factor SARS-CoV-2 severe coronavirus disease severe COVID-19 tissue damage Type type I Type I IFN type I IFNs type I interferon viral infection viral infections viral replication viruses [DOI] 10.3390/ijms231810968 PMC 바로가기
Toll-like receptors matter: plasmacytoid dendritic cells in COVID-19Toll-like 수용체의 중요성: COVID-19의 형질세포양 수지상 세포Article Published on 2022-05-162022-09-11 Journal: The EMBO Journal [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] Analysis Antiviral COVID-19 COVID-19 patients cytokine response dendritic cell dendritic cells disease severity IFN-I induce infections journal mechanisms molecular mechanism molecular mechanisms plasmacytoid dendritic cell plasmacytoid dendritic cells progenitor cell question reduced response Serum level Toll-like receptor type I interferon unique virus [DOI] 10.15252/embj.2022111208 PMC 바로가기 [Article Type] Article
TLR2 and TLR7 mediate distinct immunopathological and antiviral plasmacytoid dendritic cell responses to SARS-CoV-2 infectionTLR2 및 TLR7은 SARS-CoV-2 감염에 대한 뚜렷한 면역병리학적 및 항바이러스 형질세포양 수지상 세포 반응을 매개합니다Article Published on 2022-05-162022-09-12 Journal: The EMBO Journal [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] Antiviral antiviral interferon circulating COVID-19 patient Critical CXCL10 cytokine de novo decreased expression dendritic cell disease severity driving engage epithelial cell identify IFNs IFNα IL-6 IL-8 immunopathological in vitro Inflammatory Inflammatory response innate immune innate immune pathways innate immune sensing interferon response mitigate molecular Neuropilin-1 pathway pDC pDC. pDCs plasmacytoid dendritic cell potential therapeutic target PROTECT receptor response responsible SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 replication severe COVID-19 Signaling symptom onset systemic inflammatory TLR2 TLR7 Treatment type I understanding Via virus [DOI] 10.15252/embj.2021109622 PMC 바로가기 [Article Type] Article
Do reduced numbers of plasmacytoid dendritic cells contribute to the aggressive clinical course of COVID-19 in chronic lymphocytic leukaemia?감소된 수의 형질세포양 수지상 세포가 만성 림프구성 백혈병에서 COVID-19의 공격적인 임상 경과에 기여합니까?Review Published on 2022-04-012022-09-11 Journal: Scandinavian journal of immunology [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] agammaglobulinemia BTK Chronic lymphocytic leukaemia Clinical course CLL combating contribute COVID-19 dendritic cells Express haematological malignancies inhibitor interferon interferons IRF7 malignancies mechanism observations patients patients with haematological pDC pDCs plasmacytoid dendritic cell plasmacytoid dendritic cells reduced reduction in SARS-CoV-2 TLR7 Toll-like receptor toll-like receptor 7 type I interferons tyrosine X-linked X-linked agammaglobulinemia [DOI] 10.1111/sji.13153 PMC 바로가기 [Article Type] Review
Myeloid cell interferon responses correlate with clearance of SARS-CoV-2골수 세포 인터페론 반응은 SARS-CoV-2 제거와 관련이 있습니다Article Published on 2022-02-032022-09-10 Journal: Nature Communications [Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료제, [키워드] accumulation ACE2 angiotensin angiotensin-converting enzyme 2 Anti-viral appearance BAL baseline Bronchoalveolar lavage CD163 CD68 Cell cell suspension changes in clearance of SARS-CoV-2 correlated COVID-19 patients COVID-19-related death dendritic cells emergence exhibiting expressing expression gene signature heterogeneous HLADR host response host responses Human immune Immune cell immune profiling immunopathology increased risk individual cells infected with SARS-CoV-2 Infection Inflammation Inflammatory Innate immunity interferon interferon response lung Lungs macaque macaques Macrophage macrophages Mutant SARS-CoV-2 myeloid observé plasmacytoid dendritic cell plasmacytoid dendritic cells Population reported response rhesus macaque rhesus macaques RNAseq SARS-CoV-2 SARS-COV-2 infection scRNAseq SIGLEC1 significantly Single Cell strain T-lymphocyte T-lymphocytes transcriptional transcriptional change Transcriptional changes Type type I interferon type I interferon response Viral viral clearance viral dynamics viral infection Viremia while [DOI] 10.1038/s41467-022-28315-7 PMC 바로가기 [Article Type] Article
Single-Cell Analysis Reveals the Immune Characteristics of Myeloid Cells and Memory T Cells in Recovered COVID-19 Patients With Different SeveritiesImmunology Published on 2022-01-032022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, [키워드] accompanied addition Analysis Antigen antigen processing B-cell CD14 CD69 CD83 collected Coronavirus disease 2019 COVID-19 CXCR4 dataset datasets dendritic cell dendritic cells disease severity downregulated downregulation exhibited FOS healthy controls HLA HLA class II HLA-DRA HLA-DRB1 IGHV3-21 immune Immune cell immune characteristics immune disorder Immunoglobulin JUN leukocyte memory T memory T cells monocyte mononuclear cell myeloid myeloid cells pathway Patient PBMCs performed Peripheral blood peripheral immune response plasmacytoid dendritic cell progression stage proportion recovered recovered COVID-19 patient Recovered COVID-19 patients recovered patient recovered patients Regulation reported severe symptom single-cell Single-cell RNA sequencing symptom onset T-cell differentiation upregulated upregulation [DOI] 10.3389/fimmu.2021.781432 PMC 바로가기 [Article Type] Immunology
SARS-CoV-2 and the Immune Response in Pregnancy with Delta Variant ConsiderationsReview Published on 2021-11-302022-10-30 Journal: Infectious Disease Reports [Category] COVID-19, [키워드] accumulate ACE2 binding CD4+ T cells CDC cells changes in circulation Combination complement concerning confirmed case contagious COVID-19 COVID-19 infection COVID-19 vaccination death Delta delta variant Effect eight elevated enzyme equity Evidence exacerbate Factor General population granulocyte greater host cell host cells hyperinflammatory state ICU admission IL-6 immune clearance immune response immunological immunomodulatory property imperative include increase in increases in infecting initial literature review Lung injury Monocytes morbidity natural killer neutrophil NICU admission Other consideration Patient phagocytic plasmacytoid dendritic cell Pregnancy pregnant pregnant women Preterm birth progesterone Proinflammatory cytokine proportion Regulatory T cell Respiratory system response SARS-CoV-2 SARS-COV-2 infection severe disease course significantly strain susceptibility susceptible Th1 TLR-7 TNF-α vaccination Vaccine Viral load virus Volume [DOI] 10.3390/idr13040091 PMC 바로가기 [Article Type] Review
Why Females Do Better: The X Chromosomal TLR7 Gene-Dose Effect in COVID-19여성이 더 잘하는 이유: 코로나19에서 X 염색체 TLR7 유전자 용량 효과Immunology Published on 2021-11-112022-09-11 Journal: Frontiers in Immunology [Category] MERS, SARS, 치료법, [키워드] age biallelic caused concerning contribute COVID-19 COVID-19 pandemic COVID-19 treatment dendritic cells Effect expression Factor female gene-dose effect Hypothesis ICU IFN IFN pathway IFN response Immune cell immune cells Immunopathogenesis inactivation Infection interferon investigated Male sex modulation Mortality Pattern recognition pattern recognition receptor Pattern recognition receptors plasmacytoid dendritic cell plasmacytoid dendritic cells Protective responsible SARS-CoV-2 severe COVID-19 severity Sex difference sex differences sex hormone Sex hormones ssRNA TLR TLR7 TLR7 gene Toll-like receptor Treatment type 1 interferon Viral viral infections X chromosome X chromosome inactivation escape [DOI] 10.3389/fimmu.2021.756262 PMC 바로가기 [Article Type] Immunology