Vector control: agents of selection on malaria parasites?article Published on 2022-10-312024-09-01 Journal: Trends in Parasitology [Category] 말라리아, [키워드] extrinsic incubation period life history Mosquito Plasmodium plasticity Sporogony Transmission [Article Type] article
As the virus evolves, so too must we: a drug developer’s perspective : We need a new paradigm in searching for next-generation countermeasuresArticle Published on 2022-10-102022-11-15 Journal: Virology Journal [Category] COVID19(2023년), SARS, 변종, 치료제, [키워드] addition antibody Antiviral approach cellular immunity COVID19 develop drug drug resistance drugs Effect effective Evolution of SARS-CoV-2 Genetic greater HAD HDTx host-directed antiviral Host-directed therapeutics humoral immune immune evasion in sight infections offer omicron Pandemic countermeasures Perspective plasticity population immunity Quasispecies recombinant reduce risk SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 virus selective severity strain Treatment Vaccine variant variants virus [DOI] 10.1186/s12985-022-01887-y PMC 바로가기
Omicron BA.1 breakthrough infection drives cross-variant neutralization and memory B cell formation against conserved epitopesArticle Published on 2022-09-162022-11-16 Journal: Science Immunology [Category] SARS, 변종, [키워드] acute respiratory syndrome alteration amplification B cells Breakthrough infection Cell conserved coronavirus effective epitope evade Heterologous Immunity individual MEM memory B neutralization Neutralizing activity omicron plasticity recall recognizing robust SARS-CoV-2 SARS-CoV-2 spike glycoprotein selective susceptibility variant variants VoC [DOI] 10.1126/sciimmunol.abq2427 PMC 바로가기
X-ray crystallographic characterization of the SARS-CoV-2 main protease polyprotein cleavage sites essential for viral processing and maturationArticle Published on 2022-09-032022-11-16 Journal: Nature Communications [Category] SARS, 변종, [키워드] Analysis Antiviral binding C-terminal C-terminally capture catalytic cause cleavage cleavage site cleavage sites Complete complex coronavirus 2 COVID-19 enzyme event form Interaction M pro maturation mutant non-structural protein pathogen plasticity polyprotein polyproteins Prevent protease provide representing respiratory responsible SARS-CoV-2 specificity substrates the SARS-CoV-2 therapeutic unique X-ray X-ray crystallographic structure [DOI] 10.1038/s41467-022-32854-4 PMC 바로가기
Stem cells, cell therapies, and bioengineering in lung biology and disease 2021Article Published on 2022-09-012022-11-15 Journal: American journal of physiology. Lung cellular and [Category] 진단, [키워드] airway Analysis biennial bioengineering Biology Cell cells cellular college COVID-19 pandemic Cystic differentiation disease Extracellular Extracellular matrix feature foundation heart human lung lung Lung diseases lung regeneration lung tissues Medicine Microscopy plasticity pluripotent stem cells pluripotent stem cells. proteomics recommendation Regulation remained Research Signaling Society STEM stem cell Therapies translational Treatment University of Vermont viral infection [DOI] 10.1152/ajplung.00113.2022 PMC 바로가기
Targeted escape of SARS-CoV-2 in vitro from monoclonal antibody S309, the precursor of sotrovimabArticle Published on 2022-08-242022-11-15 Journal: Frontiers in Immunology [Category] SARS, 진단, [키워드] ACE2 ACE2 binding ACE2 binding site Amino acid angiotensin-converting enzyme 2 antibody Cell cell entry class conserved domain endocytosis Entry epitope escaped Evolution Evolution of SARS-CoV-2 fusion immune Immune escape immunological in vitro infections inhibit SARS-CoV-2 Interaction monoclonal monoclonal antibody not affected pathogenicity plasticity precursor Receptor-binding domain replicated S309 SARS-CoV-2 Sotrovimab susceptible the spike protein vaccination viral strain wild-type SARS-CoV-2 [DOI] 10.3389/fimmu.2022.966236 PMC 바로가기
Long-lasting, dissociable improvements in working memory and long-term memory in older adults with repetitive neuromodulation Research Published on 2022-08-222022-10-05 Journal: Nature Neuroscience [Category] 유전자 메커니즘, [키워드] baseline benefit Brain Cognitive function cortical ENhance improvement Improvements individual Intervention memory modulation Older parameter plasticity predicted PROTECT protocol selective synchronous translational [DOI] 10.1038/s41593-022-01132-3 [Article Type] Research
A global lipid map reveals host dependency factors conserved across SARS-CoV-2 variants글로벌 지질 지도는 SARS-CoV-2 변이체 전반에 걸쳐 보존된 숙주 의존성 요인을 보여줍니다Article Published on 2022-06-172022-09-11 Journal: Nature Communications [Category] COVID19(2023년), SARS, 바이오마커, 변종, [키워드] Alpha alteration blocked change conserved effective Factor Host human cell human cells Infection inhibitors Lipid lipid metabolism metabolism plasticity reveal SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 variant significantly Support transfecting variants of concern viral propagation Viral protein virus [DOI] 10.1038/s41467-022-31097-7 PMC 바로가기 [Article Type] Article
Analysis of SARS-CoV-2 known and novel subgenomic mRNAs in cell culture, animal model, and clinical samples using LeTRS, a bioinformatic tool to identify unique sequence identifiers고유한 서열 식별자를 식별하는 생물정보학 도구인 LeTRS를 사용하여 세포 배양, 동물 모델 및 임상 샘플에서 SARS-CoV-2 알려진 및 신규 서브게놈 mRNA 분석Article Published on 2022-05-262022-09-11 Journal: GigaScience [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus animal model animal models bioinformatics Biology biology of SARS-CoV-2 can be used Cell Cell culture clinical sample clinical samples complex coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 data set diagnostics Direct RNA sequencing Each evaluate generate host response identify implication in some indicated Infection junction longitudinal samples mammalian mechanism medical countermeasure Medical countermeasures Middle East Middle East respiratory syndrome Coronavirus multiphasic Nanopore nasopharyngeal sample nucleic acid open reading frames other coronavirus other coronaviruses Patient plasticity provide Quantitative reflected Regulatory respiratory syndrome coronavirus RNA RNA modification SARS-CoV-2 selection pressure sequence Sequencing sequencing data severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 sgmRNA sgmRNAs subgenomic mRNA subject target targets Transcription transcriptional regulatory sequences transcriptional regulatory sequences. Transmission model unique variant Viral RNA viral RNA synthesis virus was tested [DOI] 10.1093/gigascience/giac045 PMC 바로가기 [Article Type] Article
Computer Simulations and Network-Based Profiling of Binding and Allosteric Interactions of SARS-CoV-2 Spike Variant Complexes and the Host Receptor: Dissecting the Mechanistic Effects of the Delta and Omicron MutationsSARS-CoV-2 스파이크 변이체 복합체와 숙주 수용체의 결합 및 알로스테릭 상호작용에 대한 컴퓨터 시뮬레이션 및 네트워크 기반 프로파일링: 델타 및 오미크론 돌연변이의 기계적 효과 분석Article Published on 2022-04-152022-09-11 Journal: International Journal of Molecular Sciences [Category] COVID19(2023년), SARS, 변종, [키워드] ACE2 ACE2 complexes ACE2 host receptor allosteric communications analyses angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 binding binding energetics binding energy binding interaction Community Community network complexes computer constellation contribute Critical Delta Effect energetics Epitopes escape mutants examined functional generate Host host receptor hotspot identify immune evasion integrity Interaction interactions Local MD simulation modulate molecular molecular dynamics Mutation mutational scanning N501Y network analysis omicron Omicron variants plasticity Profiling RBD-ACE2 residue responsible S protein S-RBD SARS-CoV-2 SARS-CoV-2 S protein SARS-CoV-2 spike SARS-CoV-2 spike protein sensitivity signal transmission. Simulation spike Spike protein the RBD the SARS-CoV-2 Transmissibility Transmission variant variants virus [DOI] 10.3390/ijms23084376 PMC 바로가기 [Article Type] Article