Mechanisms of radiation-induced endothelium damage: Emerging models and technologies
Review article
[키워드] Activation
acute radiation syndrome
Adherens junctions
AJAdherens junctions
alteration
apoptotic pathways
ARSAcute radiation syndrome
Ataxia telangiectasia-mutated
ATMAtaxia telangiectasia-mutated
biomimetic microfluidic assay
bMFAbiomimetic microfluidic assay
cardiovascular disease
cell interactions
cellular and molecular
Central nervous system
CNSCentral Nervous System
Critical
CVDCardiovascular disease
Damage-associated molecular patterns
DAMPDamage-associated molecular patterns
develop
Developing
dysfunction
ECEndothelial cell
endothelial
Endothelial cell
Endothelium
exposure
G-CSFgranulocyte-colony stimulating factor
Gastrointestinal
Geranylgeranylacetone
GGAGeranylgeranylacetone
GIGastrointestinal
GM-CSFGranulocyte/Macrophage Colony Stimulating Factor
granulocyte-colony stimulating factor
Granulocyte/Macrophage Colony Stimulating Factor
Human umbilical vein endothelial cells
HUVECHuman umbilical vein endothelial cells
ICAM-1Intercellular adhesion molecule 1
IL-1interleukin-1
in vitro model
in vivo
Inflammatory response
Injury
Intercellular adhesion molecule 1
interleukin-1
ionizing radiation
IRionizing radiation
JAK1Janus kinase 1
JAM-CJunctional adhesion molecule-C
Janus kinase 1
Junctional adhesion molecule-C
knowledge
LETLinear energy transfer
leukocyte
Linear energy transfer
M-CSFmacrophage colony-stimulating factor
macrophage colony-stimulating factor
major histocompatibility complex
management
Manganese-dependent superoxide dismutase
mechanism
Medical countermeasures
MHCMajor Histocompatibility Complex
Microphysiological systems
MnSODManganese-dependent superoxide dismutase
morbidity and mortality
MPSMicrophysiological systems
NETsNeutrophil Extracellular Traps
Neutrophil extracellular traps
nuclear
organ damage
organs
oxygen radical
PAFPlatelet activating factor
PAI-1plasminogen activator inhibitor type 1
pathology
PDGFplatelet-derived growth factor
PKCδProtein Kinase C-delta
plasminogen activator inhibitor type 1
platelet activating factor
platelet-derived growth factor
Prevent
protease
PROTECT
Protein Kinase C-delta
Radiation
radiological
Radiotherapy
reactive oxygen species
resulting
ROSreactive oxygen species
SRSStereotactic radiosurgery
stereotactic radiosurgery
TBItotal body irradiation
TEERTransendothelial electrical resistance
TGFβTransforming Growth Factor-Beta
therapeutic
thought
thrombomodulin
tight junctions
tissue
tissue damage
tissue injury
TJTight junctions
TMthrombomodulin
TNF-αtumor necrosis factor-α
total body irradiation
Transendothelial electrical resistance
Transforming Growth Factor-Beta
Treatment
tumor necrosis factor-α
TYK2Tyrosine Kinase 2
Tyrosine Kinase 2
Vascular damage
WBCWhite blood cells
Weapons of mass destruction
White blood cells
WMDWeapons of mass destruction
[DOI] 10.1016/j.radonc.2021.02.007 [Article Type] Review article
[DOI] 10.1016/j.radonc.2021.02.007 [Article Type] Review article