Zoster-Associated Prothrombotic Plasma Exosomes and Increased Stroke RiskArticle Published on 2023-04-182023-05-31 Journal: The Journal of Infectious Diseases [Category] 두창, 수두, 홍역, [키워드] Exosomes Inflammation platelet activation stroke thrombosis Varicella zoster virus. [DOI] 10.1093/infdis/jiac405 PMC 바로가기
Platelet Reactivity and Inflammatory Phenotype Induced by Full-Length Spike SARS-CoV-2 Protein and Its RBD DomainArticle Published on 2022-12-022023-07-11 Journal: International Journal of Molecular Sciences [Category] COVID19(2023년), [키워드] platelet activation platelet aggregation RBD domain SARS-CoV-2 spike protein. [DOI] 10.3390/ijms232315191 PMC 바로가기
Persisting Platelet Activation and Hyperactivity in COVID-19 SurvivorsArticle Published on 2022-11-112023-07-10 Journal: Circulation research [Category] COVID19(2023년), [키워드] Extracellular vesicles hypercoagulability platelet activation post acute COVID-19 syndrome. [DOI] 10.1161/CIRCRESAHA.122.321659 PMC 바로가기
The deglycosylated form of 1E12 inhibits platelet activation and prothrombotic effects induced by VITT antibodiesArticle Published on 2022-10-012022-11-15 Journal: Haematologica [Category] 진단, [키워드] activate Activation addition adenoviral vector vaccine antibodies antibody Autoimmune bind chimeric COVID-19 COVID-19 vaccines demonstrated Effect epitope Fc fragment granulocyte help IgG antibodies immune IMPROVE induce inhibit interact Mouse models NETosis neutralize Neutrophils overlapping Pathogenesis pathogenic pathophysiology PF4 Platelet platelet activation Prevent prothrombotic receptors recognize Support thrombosis thrombotic Trigger Whole blood [DOI] 10.3324/haematol.2021.280251 PMC 바로가기
The impact of platelets on pulmonary microcirculation throughout COVID-19 and its persistent activating factorsArticle Published on 2022-09-282022-11-15 Journal: Frontiers in Immunology [Category] 치료제, [키워드] activate activating addition aggregation antiplatelet Blood coagulation factor complex convalescent COVID-19 COVID-19 patients disease severity disorders endothelial injury Factor Gas exchange hypercoagulability hypercoagulable hypercoagulable states Hypoxemia hypoxia immune cells impaired lung function impairment incidence Inflammation Inflammatory mediators inhibiting Intervention intrinsic involved Lung function manifestation marker microvesicle Microvesicles Mild Mortality Phosphatidylserine Platelet platelet activation Platelets promote PROTECT pulmonary permeability pulmonary vasculitis reactivity reducing resulting risk severe cases stages the disease therapy Thromboembolism thrombosis thrombosis. thrombotic event tissue Treatment vessel walls with COVID-19 [DOI] 10.3389/fimmu.2022.955654 PMC 바로가기
Early but reversible haemostatic changes in a-symptomatic females expressing COVID-19 antibodiesCOVID-19 항체를 발현하는 무증상 여성의 초기이지만 가역적인 지혈 변화Article Published on 2022-09-012022-09-12 Journal: Thrombosis research [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] age and gender aggregation antibody Antibody Response Asymptomatic COVID-19 carried change changes in circulating coagulation parameter Cohort cohort study Control coronavirus country COVID-19 COVID-19 antibody COVID-19 pandemic COVID-19-associated coagulopathy Effect effort expressing extracellular vesicle female Female patients globe Haemoglobin highest IgM and IgG individual Infection initial intensive care treatment male Mortality participant Participants pathway Platelet platelet activation Platelet responsiveness. positive positive COVID-19 Prevalence Prothrombin time risk serious complication significant decrease significant increase Spread subject unique vaccination Vaccine viral mutation were assessed with COVID-19 [DOI] 10.1016/j.thromres.2022.07.012 PMC 바로가기 [Article Type] Article
Evidence of SARS-CoV-2 spike protein on retrieved thrombi from COVID-19 patientsCOVID-19 환자로부터 회수된 혈전에서 SARS-CoV-2 스파이크 단백질의 증거Article Published on 2022-08-162022-09-11 Journal: Journal of Hematology & Oncology [Category] SARS, 치료기술, 치료법, [키워드] activate addition analyzed Chain Reaction Coagulopathy complex COVID-19 COVID-19 patient detect evidence of FIBRIN Hypothesis Ischemic Stroke Molecular biology Myocardial infarction nucleocapsid protein ogen pathophysiology pilot study Platelet platelet activation Platelets polymerase chain polymerase chain reaction real-time polymerase chain reaction retrieved SARS-CoV-2 RNA SARS-CoV-2 spike protein Spike protein stroke Support These data thrombi Trigger virus [DOI] 10.1186/s13045-022-01329-w PMC 바로가기 [Article Type] Article
Thrombocytopenia and splenic platelet-directed immune responses after IV ChAdOx1 nCov-19 administrationIV ChAdOx1 nCov-19 투여 후 혈소판 감소증 및 비장 혈소판 유도 면역 반응Article Published on 2022-08-042022-09-11 Journal: Blood [Category] SARS, 치료기술, 치료제, [키워드] accompanied acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Adenovirus adenovirus vaccine adenovirus-based administration aggregate anatomic sites antibody antiplatelet antiplatelet antibody approach Autoimmune response Autoimmunity B-cell response binding ChAdOx1 ChAdOx1 nCoV-19 characterized circulating antibodies circulating antibody clinical entities Complication contribute coronavirus followed by glycoprotein heparin heparin-induced thrombocytopenia highlight immune response Immune thrombocytopenia in vitro in vivo model Intramuscular injection IV injection Macrophage macrophages marginal zone mechanism mice pathology Patient phagocytosed Platelet platelet activation platelet factor 4 Platelets potential mechanism prothrombotic state receptor SARS-CoV-2 severe acute respiratory syndrome Coronavirus spleen thrombocytopenia thrombosis Trigger vaccination Vaccine zone [DOI] 10.1182/blood.2021014712 PMC 바로가기 [Article Type] Article
Long-Term Outcomes after Vaccine-Induced Thrombotic Thrombocytopenia백신 유도성 혈전성 혈소판 감소증 후 장기 결과Article Published on 2022-08-012022-09-11 Journal: Viruses [Category] SARS, 진단, 치료기술, [키워드] acute phase Adenovirus adenovirus-based affected antibody Anticoagulants anticoagulation appear Arterial thrombosis AZD1222 bleeding cerebral venous sinus thrombosis ChAdOx1 ChAdOx1 nCoV-19 Cohort Cohort studies cohort study Complication coronavirus Corticosteroids COVID-19 D-dimer detectable diagnosed Diagnosis died dimer Direct discharge discharged eculizumab effective elevated enrolled Follow-up hospital hospital discharge Immunoglobulin in some Intravenous immunoglobulin IVIG limit management nCoV neurological nine observation occurred one patient oral anticoagulant outcome Patient patients PF4 Platelet platelet activation positive prothrombotic condition remained respiratory respiratory syndrome coronavirus respiratory syndrome coronavirus 2 Safe SARS-CoV-2 serious complication Seven severe respiratory syndrome single-center Sinus thrombosis survived Symptom symptom onset syndrome the disease thrombocytopenia thromboembolic Thromboembolic event Thromboembolic events thrombosis thrombotic Thrombotic thrombocytopenia Treatment two patients vaccination vaccination. Vaccine venous venous sinus were given [DOI] 10.3390/v14081702 PMC 바로가기 [Article Type] Article
Increased plasma level of soluble P-selectin in non-hospitalized COVID-19 convalescent donors입원하지 않은 COVID-19 회복기 기증자에서 가용성 P-셀렉틴의 혈장 수준 증가Article Published on 2022-08-012022-09-11 Journal: Thrombosis research [Category] MERS, 바이오마커, 임상, [키워드] Activation acute disease baseline characteristics Biomarker Blood blood donor Blood donors blood sampling CD62P Characteristics Coagulation Coagulation system comparable Control controls convalescent coronavirus coronavirus disease coronavirus disease-2019 COVID-19 COVID-19 convalescent donor COVID-19 convalescent donors COVID-19 diagnosis COVID-19 symptom COVID-19 symptoms decrease demonstrated disease disease severity Donor donors ELISA endothelial evaluated Factor flow cytometry hospitalized COVID-19 patient hospitalized COVID-19 patients implication in vitro Increased lead longitudinal study marker Moderate COVID-19 MOST non-infected P-selectin Participation phenotype plasma plasma concentration Plasma marker plasma samples Platelet platelet activation Platelet function procoagulant questionnaire recruited reported Research SARS-CoV-2 SARS-COV-2 infection significantly higher Soluble P-selectin. study groups suffered systemic disease Transmission Trial Vascular was determined was measured was obtained was performed were recorded [DOI] 10.1016/j.thromres.2022.06.014 PMC 바로가기 [Article Type] Article