A phase I, first-in-human study to evaluate the safety and tolerability, pharmacokinetics, and pharmacodynamics of MRG-001 in healthy subjectsarticle Published on 2023-08-252024-09-05 Journal: Cell Reports Medicine [Category] update2024, [키워드] clinical trial healthy volunteers MRG-001 Pharmacodynamics pharmacokinetics Phase I Plerixafor Safety stem cells tacrolimus [DOI] 10.1016/j.xcrm.2023.101169 PMC 바로가기 [Article Type] article
Plerixafor and resatorvid inhibit hepatitis B virus in vitro by upregulating elongation factor Tu GTP-binding domain containing 2Article Published on 2023-02-202023-06-12 Journal: Frontiers in Cellular and Infection Microbiology [Category] B형 간염, [키워드] EFTUD2 Hepatitis B virus Plerixafor resatorvid small-molecule agents. [DOI] 10.3389/fcimb.2023.1118801 PMC 바로가기
Inhibitory potential of repurposed drugs against the SARS-CoV-2 main protease: a computational-aided approachArticle Published on 2022-05-012022-10-04 Journal: Journal of biomolecular structure & dynamics [Category] COVID19(2023년), SARS, 신약개발, [키워드] approach approaches binding binding score binding site carried co-crystallized complexes coronavirus disease COVID-19 demonstrated develop docking docking result docking study drug FIVE form higher affinity Hypothesis in silico increase in Infection inhibitors of SARS-CoV-2 inhibitory effect Interaction investigated lamivudine Ligand ligands Lopinavir M pro molecular docking molecular dynamics Mortality MPro physico-chemical properties Plerixafor predicted Protease inhibitor Protein receptor Repurposed drug residue RMSD fluctuation SARS-CoV-2 the SARS-CoV-2 trajectory treat [DOI] 10.1080/07391102.2020.1847197 PMC 바로가기 [Article Type] Article
Blockers of the SARS-CoV-2 3a Channel Identified by Targeted Drug Repurposing표적 약물 용도 변경으로 식별된 SARS-CoV-2 3a 채널 차단기Article Published on 2021-03-232022-08-31 Journal: Viruses [Category] SARS, 신약개발, 치료제, [키워드] antiviral drugs assays bacterial assays biosafety blocker Capreomycin channel channel blockers Coronaviridae COVID-19 pandemic Darapladib drug effort etiological agent Floxuridine Fludarabine Flumatinib Identified inhibit ion channels kasugamycin library Litronesib Measures member Membrane proteins pathogen Pentamidine Plerixafor repurposing Research SARS-CoV-2 screened spectinomycin Stage suggested the Coronaviridae the SARS-CoV-2 the stage these compound these compounds Treatment viral channels virus [DOI] 10.3390/v13030532 PMC 바로가기 [Article Type] Article
Plerixafor and related macrocyclic amines are potential drug candidates in treatment of malaria by “filling the flap” region of plasmepsin enzymesarticle Published on 2018-09-302024-09-01 Journal: Med Hypotheses [Category] 말라리아, [키워드] heme hemoglobin macrocycle malaria Plasmepsin Plerixafor [Article Type] article