SARS-CoV-2 infects neurons and induces neuroinflammation in a non-human primate model of COVID-19Article Published on 2022-11-012022-11-15 Journal: Cell Reports [Category] COVID19(2023년), SARS, 진단, 치료기술, [키워드] accompanied acute respiratory syndrome astrocytes Brain cellular mechanism CNS coronavirus coronavirus disease COVID-19 CP: Microbiology CP: Neuroscience Diabetic exacerbated High-resolution induce infect Infection initial investigated macaque microglia Microscopy modulated molecular Neuroinflammation Neurological complication Neurological complications Neuron neuronal neurotropism NHP non-human primate model olfactory patients plethora provide reducing Region rhesus rhesus. robust SARS-CoV-2 systemic inflammatory response triggered [DOI] 10.1016/j.celrep.2022.111573 PMC 바로가기
Toxicity and virucidal activity of a neon-driven micro plasma jet on eukaryotic cells and a coronavirusArticle Published on 2022-10-012022-11-15 Journal: Free radical biology & medicine [Category] COVID19(2023년), SARS, 치료제, [키워드] abrogated airway antioxidant antiviral activity chronic wound clinics Cold Cold physical plasma complex Contact coronavirus cytotoxic effect cytotoxicity Direct Effect Effects eukaryotic cell fibroblast Gas plasma technology Hepatitis human cell line human cells human coronaviruses identify inactivation increasingly infections mechanism metabolic activity MHV murine murine hepatitis virus number of infected oxygen pandemic Patient physical plasma plethora reactive oxygen reactive oxygen species reduced responsible ROS ROS production Safe substrate the SARS-CoV-2 therapeutic purposes tissue Toxicity treat Treatment unique viability virucidal virus inactivation [DOI] 10.1016/j.freeradbiomed.2022.08.026 PMC 바로가기
Saliva sample for detection of SARS-CoV-2: A possible alternative for mass testingArticle Published on 2022-09-282022-11-15 Journal: PLoS ONE [Category] SARS, 치료기술, [키워드] Accuracy Analysis analyzed comparable COVID-19 COVID-19 diagnosis COVID-19 pandemic COVID-19 testing Critical demographic diagnostic disease drooling E gene effective Effectiveness female individual male moderate nasal swabs Nasopharyngeal swab nasopharyngeal swab sample Negative predictive value Nigeria outbreak pandemic participant Participants plethora polymerase chain positive presenting provide reducing risk RT-PCR RT-PCR test Saliva saliva sample SARS-CoV-2 SARS-CoV-2 RdRp sensitivity significantly Specificities specimen Swab [DOI] 10.1371/journal.pone.0275201 PMC 바로가기
Dysregulated autoantibodies targeting vaso- and immunoregulatory receptors in Post COVID Syndrome correlate with symptom severityArticle Published on 2022-09-272022-11-15 Journal: Frontiers in Immunology [Category] 진단, [키워드] accompanied ADRA2A ADRB2 alteration analyzed Asymptomatic autoantibodies autoantibody autonomic Autonomic nervous system autonomous chronic chronic fatigue syndrome classification Classifier Control control group control groups correlated correlation COVID COVID-19 Diagnostic Criteria disease dysregulation Evidence exploratory study fatigue G-protein G-protein coupled receptor groups immunoregulation indicated involved ME/CFS, Mild-to-moderate MOST nervous system organ dysfunction outcomes Pathogenesis Patient patients plethora Post COVID syndrome random receptor receptors Regulatory renin-angiotensin system seronegative serum severity STAB1 subset Symptom symptom severity syndrome [DOI] 10.3389/fimmu.2022.981532 PMC 바로가기
Beyond the vaccines: a glance at the small molecule and peptide-based anti-COVID19 arsenalReview Published on 2022-09-062022-10-04 Journal: Journal of Biomedical Science [Category] SARS, 변종, 신약개발, [키워드] 3CLpro 3CLpro inhibitors accelerated ACE-2 ACE2 antibody anticipated Antiviral effect approach benefit composed Conjugates conserved Coronaviruses COVID-19 COVID-19 pandemic COVID19 drug Drug discovery effort Evidence FDA approval In-vitro inhibitor Medicinal chemistry monoclonal antibodies peptide-based peptides plethora PLPro PLpro inhibitors Predictive model Prevent Proteases Protein pursuit RdRP RdRp inhibitors Replication reported required researcher S protein SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 variant SARS-CoV-2 variants small molecule small molecule drug Small molecule inhibitors targets therapeutic option TMPRSS2 TMPRSS2 drug repurposing TMPRSS2 inhibitors Treatment vaccination vaccine platform Vaccines viral entry viral replication [DOI] 10.1186/s12929-022-00847-6 PMC 바로가기 [Article Type] Review
Experiencing the COVID-19 pandemic as a healthcare provider in rural Dhanbad, India: An interpretative phenomenological analysisRandomized Controlled Trial Published on 2022-08-252022-10-04 Journal: PLoS ONE [Category] 임상, [키워드] Analysis Care conducted coping strategies COVID-19 COVID-19 pandemic double-blind Effect emotional evaluate FIVE hcp Health healthcare help heterogenous India Infection less mechanism Mental mental health mental health problems morbidity and mortality MOST pandemic participant plethora processed Psychological Quantitative recruited Research responses second wave Stress Support transcribed unique widespread [DOI] 10.1371/journal.pone.0273573 PMC 바로가기 [Article Type] Randomized Controlled Trial
Maternal vaccination as an additional approach to improve the protection of the nursling: Anti-infective properties of breast milkArticle Published on 2022-08-102022-11-15 Journal: Clinics [Category] 진단, [키워드] anti-SARS-CoV-2 anti-SARS-CoV-2 vaccines antibody Antibody Response approach B lymphocyte bacterial antigen Bioactive factors Breast breast milk Breastfeeding chemokines complement component cytokine elevated Factors fatty acids function Growth factors hormone Human IgA IgA antibodies IgA antibody IgG antibody IMPROVE inactivated induce lactation lactoferrin leukocyte mammary Maternal maternal immunization MicroRNAs nucleic acids oligosaccharides pandemic passive immunity performed Placenta Plasma cell plethora polysaccharide Pregnancy produced Proteins respiratory infections respiratory tracts secretion secretory secretory IgA Secretory IgA antibodies. Specific specific antibody unique vaccination Vaccine Vaccines virus virus-neutralizing viruses [DOI] 10.1016/j.clinsp.2022.100093 PMC 바로가기
Treatment strategies of COVID-19: A rheumatology perspectiveCOVID-19의 치료 전략: 류마티스학적 관점Review Published on 2022-08-012022-09-12 Journal: European journal of internal medicine [Category] COVID19(2023년), SARS, 진단, 치료법, 치료제, [키워드] absence acute respiratory syndrome adaptive approved authority Colchicine Coronavirus-2 Corticosteroid COVID-19 Critical Critically ill patient Dexamethasone DMARDs effective host cell Immunity Inflammatory response inhibitors interleukin-6 janus Kinase inhibitor mAbs monoclonal antibody off-label Perspective plethora progression Proinflammatory cytokine Remdesivir Replication rheumatologist rheumatology SARS-CoV-2 SARS-CoV-2 mAbs. SARS-CoV-2 pneumonia therapeutic strategy Treatment viral entry [DOI] 10.1016/j.ejim.2022.05.014 PMC 바로가기 [Article Type] Review
Drug repurposing for identification of potential spike inhibitors for SARS-CoV-2 using molecular docking and molecular dynamics simulations분자 도킹 및 분자 역학 시뮬레이션을 사용하여 SARS-CoV-2에 대한 잠재적 스파이크 억제제 식별을 위한 약물 용도 변경Article Published on 2022-07-012022-09-11 Journal: Methods (San Diego, Calif.) [Category] COVID19(2023년), SARS, 신약개발, 치료제, [키워드] ACE2 ACE2 receptor ADME administration Analysis angiotensin antiviral drugs approved drug Asthma average binding binding affinity candidate carried Compound COVID-19 COVID-19 pandemic COVID-19 treatment death develop docking drug Drug repurposing Efficacy estimates FIVE followed by free energy Hepatitis hepatitis C host cell hosts human Angiotensin-converting enzyme Human angiotensin-converting enzyme 2 identify Immunocompromised in silico Approach in vitro in vivo inhibitor Interaction leukotriene leukotriene receptor antagonist Ligand Lineage lineages membrane-bound molecular docking molecular dynamics Molecular dynamics simulation molecular dynamics simulations Multiple Multiple studies oral administration parameter plethora Protease inhibitor receptor antagonist recognize SARS-CoV-2 SARS-CoV-2 virus SARS‐CoV‐2 selected Simeprevir Spike protein Spike proteins tested the SARS-CoV-2 virus therapeutic treat Treatment variety virus WHO Zafirlukast [DOI] 10.1016/j.ymeth.2022.02.004 PMC 바로가기 [Article Type] Article
Breakthrough infections after COVID-19 vaccination: Insights, perspectives and challengesResearch article Published on 2022-06-012022-10-05 Journal: Metabolism Open [Category] 변종, [키워드] acquisition administration age antibody Antigen Breakthrough infection breakthrough infections cause Characteristics clinical consequence Comorbidities COVID COVID-19 COVID-19 pandemic determinant Determining dose Effectiveness Host Immune escape immune evasion immune protection Immune status Immunity immunosuppressive drugs incidence Incubation period Infection Long Mortality mucosal nasal neutralizing antibody occur offer omicron Pancoronavirus pathogenicity Perspective platform plethora Public health intervention reduced reducing robust SARS-CoV-2 SARS-CoV-2 variant severe disease Severity of infection shown significantly Spread syndrome Transmissibility Transmission turn vaccinated individuals vaccination Vaccine Vaccines variant variant of concern viral variant virus [DOI] 10.1016/j.metop.2022.100180 [Article Type] Research article