PLX5622

[키워드] accompanied ACE2 Activation addition administration Antiviral causative agent CCL19 CCL2 CCL5 Central nervous system characterized chemokine CNS colony-stimulating factor consequence contribute contributing to COVID-19 COVID-19 patient COVID-19 patients Critical CXCL10 CXCL9 cytokine Defense determined by disease eIF2 evaluate Evidence exhibited expression hACE2 Host host defense human ACE2 IFN-λ Immune cell infiltration immune response immune responses immunological immunological mechanism increased expression infect infecting Infection infection with SARS-CoV-2 infiltration Inflammatory response inhibitor K18 K18-hACE2 Lung pathology macrophages MERS MERS-CoV mice microglia Mild mind Monocytes monocytes/macrophages nervous nervous system Neuroinvasive neurologic Neuron neurons Neuropathology not affect PLX5622 Pro-inflammatory genes proinflammatory Proinflammatory cytokine receptor reduction in replicate responsible RNA sequencing SARS-CoV-1 SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 replication severity Signaling survival Symptom System TNF-α transcript transgenic mice understanding Viral viral infection viral pathogen viral replication virus virus viruses
[DOI] 10.1128/jvi.01969-21 PMC 바로가기 [Article Type] Pathogenesis and Immunity