Double stranded RNA drives anti-viral innate immune responses, sickness behavior and cognitive dysfunction dependent on dsRNA length, IFNAR1 expression and age이중 가닥 RNA는 dsRNA 길이, IFNAR1 발현 및 연령에 따라 항바이러스성 선천성 면역 반응, 질병 행동 및 인지 기능 장애를 유발합니다.Article Published on 2021-07-012022-09-11 Journal: Brain, behavior, and immunity [Category] SARS, 치료법, [키워드] age age-dependent effect age-dependent effects Alzheimer's disease Analysis Anti-viral autism base binding Brain circulating CNS cognitive Cognitive function COVID19 cytokine Cytokines dependent on disease dose dsRNA dysfunction expression Gene Expression IFN-I IFNAR1 Ifnb IFNβ IL-1β IL-6 immune activation immune responses Impact implication Inflammation innate immune response innate immune responses Innate immunity integrity IRF7 memory mice molecular weight neurodegenerative disorder neurodegenerative disorders Neuroinflammation overcome parkinson s disease Parkinson's Disease plasma Poly I:C produced Psychiatric question response responses RNA robust SARS-CoV-2 Schizophrenia Sickness Sickness behaviour significantly Symptom systemic systemic inflammation TNF-α Transcription triggered type I interferon viral infection viral replication Working memory [DOI] 10.1016/j.bbi.2021.04.016 PMC 바로가기 [Article Type] Article
Immune Responses to Varicella-Zoster Virus Glycoprotein E Formulated with Poly(Lactic-co-Glycolic Acid) Nanoparticles and Nucleic Acid Adjuvants in MiceResearch Article Published on 2020-08-052024-09-04 Journal: Virologica Sinica [Category] 대상포진, [키워드] Cell-mediated immunity CpG ODN nanoparticle Nucleic acid immune stimulator PLGA Poly I:C Varicella-zoster virus subunit vaccine [DOI] 10.1007/s12250-020-00261-y PMC 바로가기 [Article Type] Research Article
Cell-traversal protein for ookinetes and sporozoites (CelTOS) formulated with potent TLR adjuvants induces high-affinity antibodies that inhibit Plasmodium falciparum infection in Anopheles stephensi세포 통과 단백질인 ookinetes와 sporozoites (CelTOS)가 강력한 TLR 보조제를 사용하여 제조되어 Anopheles stephensi에서 Plasmodium falciparum 감염을 억제하는 고친화성 항체를 유도합니다.Research Published on 2019-04-242024-08-11 Journal: Malaria Journal [Category] 말라리아, [키워드] CelTOS CpG Plasmodium falciparum Poly I:C Transmission-reducing activity (TRA) [DOI] 10.1186/s12936-019-2773-3 PMC 바로가기 [Article Type] Research
Poly I:C adjuvanted inactivated swine influenza vaccine induces heterologous protective immunity in pigsArticle Published on 2014-11-282023-06-23 Journal: Vaccine [Category] 신종인플루엔자, [키워드] Inactivated swine influenza vaccines Poly I:C swine influenza virus Vaccine adjuvants [DOI] 10.1016/j.vaccine.2014.11.034 PMC 바로가기 [Article Type] Article
Antiviral and anti-inflammatory activity of arbidol hydrochloride in influenza A (H1N1) virus infectionOriginal Article Published on 2013-08-052023-06-14 Journal: Acta pharmacologica Sinica [Category] Fulltext, 신종인플루엔자, [키워드] Antiviral agents Arbidol Cytokines Influenza Macrophage oseltamivir Poly I:C [DOI] 10.1038/aps.2013.54 PMC 바로가기 [Article Type] Original Article
Protective Role of Toll-like Receptor 3-Induced Type I Interferon in Murine Coronavirus Infection of MacrophagesArticle Published on 2012-05-242022-10-28 Journal: Viruses [Category] Coronavirus, MERS, [키워드] Activation adaptive antigen-presenting cell antiviral immunity antiviral state chemokines chronic infection coronavirus CoV CoVs Cytokines diminishe Express IFN-β IFNs Immunity induce infancy infect Infection investigation Ligand Macrophage macrophage cell line macrophages MHV MHV-A59 mouse hepatitis virus murine murine coronavirus not affect pattern recognition receptor Poly I:C positive-sense PRR PRRs RNA virus role selected single-stranded Stimulation suppresse susceptibility TLR TLR2 TLR3 TLR4 TLR7 TLRs triggering Type Type I IFN type I interferon viral infection viral infections virus production viruses [DOI] 10.3390/v4050901 PMC 바로가기 [Article Type] Article