Polygenic Risk Score for Cardiovascular Diseases in Artificial Intelligence Paradigm: A ReviewReview Article Published on 2023-11-272024-09-05 Journal: Journal of Korean medical science [Category] update2024, [키워드] artificial intelligence cardiovascular disease Genomics polygenic risk score precision medicine [DOI] 10.3346/jkms.2023.38.e395 PMC 바로가기 [Article Type] Review Article
Factors associated with anxiety disorder comorbidityarticle Published on 2023-02-152024-09-05 Journal: Journal of affective disorders [Category] update2024, [키워드] affective disorders anxiety disorders Comorbidity depressive disorders polygenic risk score [DOI] 10.1016/j.jad.2022.11.051 PMC 바로가기 [Article Type] article
Interplay between demographic, clinical and polygenic risk factors for severe COVID-19Article Published on 2022-10-132022-11-15 Journal: International Journal of Epidemiology [Category] COVID19(2023년), SARS, 변종, 치료제, [키워드] 95% CI adjusted odds ratio Admission age antiviral response association co-morbidity conducted COVID-19 COVID-19 diagnosis Critical care death develop diagnosed with COVID-19 enrolment Epidemiology European Factor Factors General population genetic data genetic risk factor Genetic variant greater highest hospital Hospitalization identify IMPROVE individual interquartile range lowest median men morbidity obesity outcomes participant Pathway analysis Pathways Patient polygenic risk score polymorphism PRS reported risk risk factor risk prediction severe COVID-19 single-nucleotide Smokers socio-demographic UK biobank was performed [DOI] 10.1093/ije/dyac137 PMC 바로가기
Host genetic loci LZTFL1 and CCL2 associated with SARS-CoV-2 infection and severity of COVID-19Research article Published on 2022-09-012022-10-05 Journal: International Journal of Infectious Diseases [Category] COVID19(2023년), SARS, 변종, 신약개발, 유전자 메커니즘, [키워드] association B.1 lineage candidate gene case-control study CCL2 cohort of patient contribute COVID-19 COVID-19 case COVID-19 severity Cytokine storm examined genetic loci genetic marker Genetic variant Genome Genome-wide association study genotyped Germany GWAS healthy control Hospitalization Hospitalized Host Host genetic factor host genetics investigated Lineage LZTFL1 MOST objective Pathogenesis patients with COVID-19 phenotype Phylogeny polygenic risk score predict reached reconstructed Result risk risk score SARS-CoV-2 SARS-CoV-2 genome SARS-COV-2 infection SARS-CoV-2 mutation SARS-CoV-2 strain sequenced severity severity of COVID-19 significantly single nucleotide polymorphisms susceptibility the SARS-CoV-2 genome variant with COVID-19 [DOI] 10.1016/j.ijid.2022.06.030 [Article Type] Research article
Development and validation of a trans-ancestry polygenic risk score for type 2 diabetes in diverse populationsarticle Published on 2022-06-292024-09-02 Journal: Genome Medicine [Category] 대상포진, [키워드] Clinical implementation Diverse populations polygenic risk score type 2 diabetes [DOI] 10.1186/s13073-022-01074-2 PMC 바로가기 [Article Type] article
Polygenic risk scores for blood pressure to assess the risk of severe bevacizumab-induced hypertension in cancer patients (Alliance)Article Published on 2022-05-262024-09-04 Journal: Clinical Pharmacology and Therapeutics [Category] 대상포진, [키워드] bevacizumab blood pressure hypertension polygenic risk score [DOI] 10.1002/cpt.2635 PMC 바로가기 [Article Type] Article
Uterine fibroid polygenic risk score (PRS) associates and predicts risk for uterine fibroidArticle Published on 2022-04-072024-09-04 Journal: Human Genetics [Category] 대상포진, [키워드] PheWAS polygenic risk score PRS uterine leiomyomata [DOI] 10.1007/s00439-022-02442-z PMC 바로가기 [Article Type] Article
MEDTEC Students against Coronavirus: Investigating the Role of Hemostatic Genes in the Predisposition to COVID-19 SeverityArticle Published on 2021-11-092022-10-30 Journal: Journal of Personalized Medicine [Category] COVID-19, [키워드] MTHFR 95%CI acute respiratory syndrome ADAMTS13 Analysis association Association analysis Characteristics characterized clinical heterogeneity Cohort conducted Control coronavirus coronavirus disease COVID-19 COVID-19 severity database degree distribution Engineering evidenced extreme functions General population Genes Genetic Genetic predisposition Hemostasis Hemostatic hemostatic genes Host intrinsic investigated Italian Manifestations median Medicine Meta-analysis MTHFR MTR pandemic performed polygenic risk score polymorphism predicted predisposition PROC Regeneron risk role SARS-CoV-2 severe COVID-19 severe COVID-19 patient severity significantly single-nucleotide student susceptibility THBS2 the disease Thromboembolic events university variant virus with COVID-19 [DOI] 10.3390/jpm11111166 PMC 바로가기 [Article Type] Article
Germline Genetic Variants of Viral Entry and Innate Immunity May Influence Susceptibility to SARS-CoV-2 Infection: Toward a Polygenic Risk Score for Risk Stratification바이러스 진입 및 선천 면역의 생식선 유전 변이가 SARS-CoV-2 감염에 대한 감수성에 영향을 줄 수 있음: 위험 계층화를 위한 다유전자 위험 점수를 향하여Review Published on 2021-03-082022-09-11 Journal: Frontiers in Immunology [Category] MERS, SARS, 변종, 치료기술, [키워드] affected affecting Alter analyzed approach association Autoimmune diseases Bacterial bacterial and viral infections caused Cell Chronic illness clinical consequences clinically complex consequence COVID-19 COVID-19 pandemic detect determinant develop Epidemics Evidence evidence of Factor focus followed by genetic association genetic associations genetic susceptibility Genome genomic genotype-phenotype association studies germline healthcare healthy individual healthy individuals immune influence Innate Innate immunity knowledge Manifestations multitude Novel coronavirus nucleotide older patient older patients polygenic risk score Previous studies previous study Protective provided Recognition risk risk stratification SARS-CoV-2 SARS-COV-2 infection score severe complications Single nucleotide polymorphism single nucleotide polymorphisms SNP SNPs susceptibility susceptibility loci variants variations Viral viral entry viral infections [DOI] 10.3389/fimmu.2021.653489 PMC 바로가기 [Article Type] Review
Dynamics of a Dual SARS-CoV-2 Lineage Co-Infection on a Prolonged Viral Shedding COVID-19 Case: Insights into Clinical Severity and Disease DurationArticle Published on 2021-02-022022-10-29 Journal: Microorganisms [Category] COVID-19, [키워드] acute respiratory syndrome clade clinical clinically Co-infection Cohort conducted contributed coronavirus coronavirus disease COVID-19 COVID-19 and SARS-CoV-2 criteria Culture Diagnosis diagnostic Duration Dynamics female Frequency healthy Home isolation Hospitalization hospitalizations identity in vitro Infection insight isolate Lineage lineages mother nine Normal distribution Patient polygenic risk score positive profile Prolonged prolonged viral shedding Reinfection resolved risk score RT-PCR tests SARS-CoV-2 screened sequenced Seven severe respiratory disease severity of COVID-19 shedding symptomatic the patient variants viral genome viral shedding viral whole-genome sequencing [DOI] 10.3390/microorganisms9020300 PMC 바로가기 [Article Type] Article