Identification of a New Potential SARS-COV-2 RNA-Dependent RNA Polymerase Inhibitor via Combining Fragment-Based Drug Design, Docking, Molecular Dynamics, and MM-PBSA CalculationsChemistry Published on 2020-10-302022-10-31 Journal: Frontiers in Chemistry [Category] COVID-19, [키워드] approved drug bind binding calculation COVID-19 COVID-19 disease COVID-19 infection deaths develop Discovery Studio docking docking score drug Dynamics enzyme experiment FIVE fragment-based drug design identification Infection inhibit inhibitor linker MM-PBSA calculations molecular molecular dynamics New pandemic PDB ID performed polymerase Polymerase inhibitors Potential predicted Protein protocol Replication reported responsible retrieved RNA Safety measure target thought virus genome Virus life cycle WHO [DOI] 10.3389/fchem.2020.584894 PMC 바로가기 [Article Type] Chemistry
In Vitro Combinations of Baloxavir Acid and Other Inhibitors against Seasonal Influenza A VirusesArticle Published on 2020-10-082023-06-07 Journal: Viruses [Category] 신종인플루엔자, [키워드] A(H1N1) virus A(H3N2) virus baloxavir Combination Human airway epithelium Influenza neuraminidase inhibitors Polymerase inhibitors [DOI] 10.3390/v12101139 PMC 바로가기 [Article Type] Article
Whole Genome Analysis and Targeted Drug Discovery Using Computational Methods and High Throughput Screening Tools for Emerged Novel Coronavirus (2019-nCoV)Article Published on 2020-05-062022-10-30 Journal: Journal of pharmaceutics and drug research [Category] COVID-19, [키워드] 2019-nCoV Analysis antiviral agent antiviral drug antiviral drugs approach bat BLASTn carried China Chloroquine coding Compound concentrations coronavirus Coronavirus infection derivative docking result Docking tools drug drug combination effective Folic acid Genome genome analysis genomic glycoprotein identify IL-2 IL-6 inhibit inhibitory ligands multi new virus niacinamide novel Novel coronavirus Novel coronavirus infection pneumonia case Polymerase inhibitors Protease inhibitor protease inhibitors Proteases Protein Protein target RdRP Ritonavir SARS Coronavirus SARS-CoV-2 Screening shown SMART BLAST and WebDSV 2.0 specific treatment spike target the disease the SARS-CoV-2 throughput treat urgency WHO Wuhan PMC 바로가기 [Article Type] Article
New antivirals for the treatment of chronic hepatitis BReview Published on 2017-07-012023-06-18 Journal: Expert opinion on investigational drugs [Category] B형 간염, [키워드] capsid inhibitors cccDNA entry inhibitors hepatitis B immunomodulators novel therapy nucleos(t)ide analogues Polymerase inhibitors RNAi TAF therapeutic vaccines. TLR7 agonist [DOI] 10.1080/13543784.2017.1333105 [Article Type] Review