Will Peptides Help to Stop COVID-19?Article Published on 2022-07-012022-11-15 Journal: Biochemistry. Biokhimiia [Category] COVID19(2023년), SARS, 변종, 진단, 치료제, [키워드] ACE2 Antiviral caused component diagnostics human diseases Interaction main receptor peptide polypeptide prevention of COVID-19 SARS-CoV-2 STOP T-cell T-cell epitopes the disease the SARS-CoV-2 therapy Vaccine Vaccines virus virus variants [DOI] 10.1134/S0006297922070021 PMC 바로가기
Intranasal Delivery of Thermostable Subunit Vaccine for Cross-Reactive Mucosal and Systemic Antibody Responses Against SARS-CoV-2SARS-CoV-2에 대한 교차 반응성 점막 및 전신 항체 반응을 위한 열안정성 소단위 백신의 비강내 전달Article Published on 2022-05-032022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] ACE2 addition Against Alpha angiotensin angiotensin converting enzyme angiotensin converting enzyme 2 anti-RBD Anti-RBD antibody antibody Antibody Response Antibody responses Antibody titer Antibody titers approved Beta binding binding domain Breakthrough infection breakthrough infections chitosan circulation COVID-19 COVID-19 vaccines CpG cross-reactive delivery Delta variants domain Efficacy effort enzyme exclusion FIVE genetic material help Hesitancy IgA antibodies IgG1 IgG2a IL-12 Immunity immunization IMPROVE induce inhibited interleukin interleukin-12 intranasal intranasal vaccination intranasally isotype Laboratory mice mucosal mucosal immunity mutant oligonucleotide polypeptide Prevent PROTECT RBD RBD-specific antibodies RBD-specific antibody receptor Receptor binding domain receptor binding domain (RBD) reduce respiratory respiratory viruses response responses room temperature SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants specific antibodies stability subcutaneous vaccination subunit Subunit vaccine systemic temperature the vaccine thermostable upper respiratory tract vaccination Vaccine Vaccine development Vaccine hesitancy vaccine platform variants virus [DOI] 10.3389/fimmu.2022.858904 PMC 바로가기 [Article Type] Article
Systematizing the genomic order and relatedness in the open reading frames (ORFs) of the coronaviruses코로나바이러스의 오픈 리딩 프레임(ORF)에서 게놈 순서와 관련성을 체계화Article Published on 2021-08-012022-09-11 Journal: Infection, genetics and evolution : journal of mol [Category] SARS, 유전자 메커니즘, 치료법, [키워드] Accessory Accessory genes accessory protein accessory proteins agent analyzed Cluster complex conserved Coronaviridae coronavirus coronavirus disease coronavirus disease-2019 CoV CoVs effort ENCODE envelope focus Frame gene clusters Genes Genome genomes genomic genus greater mechanisms membrane naming nucleocapsid Open reading frame ORF ORF gene ORF3a ORF3b ORF3c ORF3d ORF5 ORFs pandemic Phylogeny polypeptide Protein Proteins Referral RNA genome RNA genome. RNA virus RNA viruses SARS-CoV-2 structural proteins the Spike transcriptional translational viral genome [DOI] 10.1016/j.meegid.2021.104858 PMC 바로가기 [Article Type] Article
Support Vector Machine as a Supervised Learning for the Prioritization of Novel Potential SARS-CoV-2 Main Protease Inhibitors새로운 잠재적 SARS-COV-2 주요 프로테아제 억제제의 우선 순위를위한 감독 학습으로 벡터 머신을 지원합니다.Article Published on 2021-07-192022-08-31 Journal: International Journal of Molecular Sciences [Category] SARS, 신약개발, 치료제, [키워드] active against actives affected approach best binding binding interaction classification cleavage Compound compounds Consensus COVID-19 COVID-19 pandemic dataset docking docking study drugs effort enzyme evaluated FIVE helping Immunity Infection inhibitors Interaction learning machine learning main protease molecular molecular docking molecular dynamics molecular mechanisms MPro novel PDB structure polypeptide polypeptides Potential protease protease inhibitors Research responsible retrieved SARS-CoV-2 Scientific community selected stability starting submitted Support support vector machine SVM Transcription Vaccine Viral viral genome world population [DOI] 10.3390/ijms22147714 PMC 바로가기 [Article Type] Article
In silico identification of available drugs targeting cell surface BiP to disrupt SARS-CoV-2 binding and replication: Drug repurposing approachResearch article Published on 2021-05-012022-10-05 Journal: European journal of pharmaceutical sciences : offi [Category] SARS, 신약개발, [키워드] Acute inflammation analyzed anti-inflammatory drug antiviral agent Apoptosis appear approach azosemide bind binding BiP candidate caspase-dependent apoptosis Cell cell surface contribute COVID-19 COVID-19 / SARS-CoV-2 COVID-19 patients disrupt docking domain drug Drug repurposing drugs targeting expressed extrinsic FDA-approved drug functional Grapiprant hepatitis C virus identify Immune cell infected cells Inflammation inhibit Ligand molecular docking NBD Netupitant neutralize performed polypeptide predicted Prevent protease Protein receptor receptor protein Replication SARS-CoV-2 selected Significance susceptible therapeutic target treat Trigger triggering velpatasvir viral replication [DOI] 10.1016/j.ejps.2021.105771 [Article Type] Research article
Multi-schema computational prediction of the comprehensive SARS-CoV-2 vs. human interactomeBioinformatics Published on 2021-04-052022-10-28 Journal: PeerJ [Category] COVID-19, [키워드] Algorithm anti-SARS-CoV-2 therapeutics Comprehensive interactome COVID-19 Critical disease disrupt Evidence experiments highest host-pathogen interactions human protein human proteins identify information inhibitory Inter-species interaction prediction Interaction Intersection machine learning Novel coronavirus Pathogenesis polypeptide polypeptides PPI predicted Predictive predictor protein-protein interaction protein–protein interaction provided proximal Reciprocal released resource Result SARS-CoV virus SARS-CoV-2 SARS-CoV-2 protein Scientific community Seven small molecule spike-ACE2 subset target the disease the SARS-CoV-2 understanding viral disease was used [DOI] 10.7717/peerj.11117 PMC 바로가기 [Article Type] Bioinformatics
Simultaneous CD8 + T-Cell Immune Response against SARS-Cov-2 S, M, and N Induced by Endogenously Engineered Extracellular Vesicles in Both Spleen and LungsArticle Published on 2021-03-102022-10-28 Journal: Vaccines [Category] COVID-19, [키워드] acute respiratory syndrome airways anti-SARS-CoV-2 antibody Antigen antigen-presenting cells approach C-terminal C-terminus CD8 CD8+ T cell immunity Cell coding coronavirus CTL detectable DNA Efficiency Evidence EVs expressing expression vector extracellular vesicle Extracellular vesicles fused fusion protein HIV-1 immune response Immunity in vivo inactive induce induced injected Intramuscular injection lung Lungs lymphocyte mice MOST Nef polypeptide Protein provided released response S1 and S2 SARS-CoV-2 SARS-CoV-2 antigen Simultaneous spleen T cell T-cells vaccination Vaccine vector viral antigens [DOI] 10.3390/vaccines9030240 PMC 바로가기 [Article Type] Article
Host mitochondrial transcriptome response to SARS-CoV-2 in multiple cell models and clinical samples여러 세포 모델 및 임상 샘플에서 SARS-CoV-2에 대한 호스트 미토콘드리아 전사체 반응Article Published on 2021-01-082022-09-10 Journal: Scientific Reports [Category] 유전자 메커니즘, [키워드] analyzed BALF Cell cell lines cellular cellular respiration clinical sample clinical samples Complex I disrupt downregulated expression Gene Expression induce Infection innate immune response Innate immunity lung MAVS Mitochondria mitochondrial NEM Open reading frame open reading frames Other respiratory viruses polypeptide polypeptides primary cells Protein regulate respiratory respiratory viruses RNAseq RNAseq data SARS-CoV SARS-CoV-2 shown Signaling Transcriptome [DOI] 10.1038/s41598-020-79552-z PMC 바로가기 [Article Type] Article
Evaluation of acridinedione analogs as potential SARS-CoV-2 main protease inhibitors and their comparison with repurposed anti-viral drugsResearch article Published on 2021-01-012022-10-05 Journal: Computers in biology and medicine [Category] SARS, 신약개발, [키워드] Analysis anti-viral drug Antiviral antiviral drug binding binding energy binding pocket comparable conformational COVID-19 exhibited indicated infected individuals inhibit inhibitor inhibitors of SARS-CoV-2 Interaction involved long term main protease MD simulation MM-PBSA MPro performed polypeptide progression protease required residue Result saquinavir SARS-CoV-2 SARS-CoV-2 main protease screened seated selected target the SARS-CoV-2 Transcription viral genome replication [DOI] 10.1016/j.compbiomed.2020.104117 [Article Type] Research article
Prediction and evolution of B cell epitopes of surface protein in SARS-CoV-2Research Published on 2020-10-292022-10-28 Journal: Virology Journal [Category] COVID-19, MERS, SARS, [키워드] Amino acid Analysis analyzed antibodies antibody antigenic applied B cell epitope bioinformatics caused Characteristics conformational conserved coronavirus determinant disease effective epitope Epitopes Evolution experiment facilitate form Frequency GISAID immune system linear linear epitope membrane Mutation natural proteins NC_045512.2 NCBI polypeptide polypeptides predict predicted prediction Prevent Proteins recognize reference Result SARS-CoV-2 SARS-CoV-2 genomes SARS-CoV-2 vaccine sequence stimulate surface protein the SARS-CoV-2 the vaccine threat Vaccine development vector whole genome [DOI] 10.1186/s12985-020-01437-4 PMC 바로가기 [Article Type] Research