Incidence of SARS-COV-2 infection among swimming athletes: data from real life in Apulia (Italy), July 2020/August 2021Observational Study Published on 2023-01-012023-07-08 Journal: Annali di igiene : medicina preventiva e di comunità [Category] COVID19(2023년), [키워드] COVID-19 pool sport activities. [DOI] 10.7416/ai.2022.2520 [Article Type] Observational Study
Practical considerations to establish a validated platform for pooled detection of SARS-CoV-2 by droplet digital PCRArticle Published on 2022-11-042022-11-15 Journal: PLoS ONE [Category] SARS, 치료기술, [키워드] addition affected amplification analyzed approach Blood carried COVID-19 pandemic Critical Ct value detect detection diagnostic diagnostic capabilities digital PCR Dilution droplet False negative Health hospital Infectious disease inhibitors invasive Laboratory less limitation Nasopharyngeal samples parameter PCR platform pool positive sample reagent reagents reduce reducing resources resulting risk Saliva SARS-CoV-2 sensitivity the SARS-CoV-2 virus load was performed [DOI] 10.1371/journal.pone.0271860 PMC 바로가기
Is IFN expression by NK cells a hallmark of severe COVID-19?Research article Published on 2022-09-012022-10-05 Journal: Cytokine [Category] 변종, 치료기술, 치료제, [키워드] addition CD107a clinical form contribute CoV COVID-19 cytolytic cytotoxic activity Cytotoxic granules decrease Defense disease elicited Express expression form Frequency Granule granzyme B groups hallmark Host IFN IFN-α IFN-γ immune responses immune system individual Innate immunity interferons involved Ki-67 Killer cell mechanism Mild natural Natural killers NK cell NK cells pathogenesis of COVID-19 PBMC PBMCs peptide pool profile question recovered COVID-19 patient reduced SARS-CoV-2 severe COVID-19 severity significant increase spike the disease the healthy viruses Volunteer [DOI] 10.1016/j.cyto.2022.155971 [Article Type] Research article
High-Throughput COVID-19 Testing of Naso-Oropharyngeal Swabs Using a Sensitive Extraction-Free Sample Preparation MethodArticle Published on 2022-08-312022-11-15 Journal: Microbiology Spectrum [Category] SARS, 치료기술, [키워드] approach calibrated Cobas costly COVID-19 detection system diagnosis of SARS-CoV-2 diagnostic Direct direct method downstream extraction-free extraction-free method gold standard High-throughput Infection International lack less log medium naso-oropharyngeal swab nasopharyngeal swab specimen nucleic acid extraction offer ORF1ab outcome PCR PCR assay per day PlexPCR pool positive sample preparation proteinase protocol purification quantification RdRP reagent reagents reduction in required Respiratory Coronavirus reverse transcription-PCR RNA Roche Sample SARS-CoV-2 SARS-CoV-2 detection SARS-CoV-2 RNA sensitive sensitivity tested Testing time-consuming Transport Treatment Viral load Viral RNA WHO [DOI] 10.1128/spectrum.01358-22 PMC 바로가기
Safety and Immunogenicity of an Inactivated Severe Acute Respiratory Syndrome Coronavirus 2 Vaccine in a Subgroup of Healthy Adults in ChileArticle Published on 2022-08-242022-11-15 Journal: Clinical Infectious Diseases: An Official Publicat [Category] SARS, 진단, 치료기술, [키워드] activate acute respiratory syndrome Adverse reaction age analyzed binding domain blood sample cellular characterized Chilean circulating clinical trial CoronaVac coronavirus coronavirus 2 coronavirus disease COVID-19 dose effective vaccine enrolled healthy humoral IFN-γ IgG immunogenicity Immunoglobulin inactivated incidence induce injection interferon-γ Local measure Mild neutralizing antibody neutralizing capacity Pain peptide Phase 3 phase 3 clinical trial Placebo pool profiles promote Randomly RBD Registered reported respiratory Safe Safety SARS-CoV-2 SARS-CoV-2 antigens second dose secretion separated severe adverse event significant increase subset T cells T-cell Response the vaccine Vaccine Vaccines Volunteer volunteers was performed [DOI] 10.1093/cid/ciab823 PMC 바로가기
One Solution for All: Searching for Universal Aptamers for Constantly Mutating Spike Proteins of SARS-CoV-2모두를 위한 하나의 솔루션: SARS-CoV-2의 스파이크 단백질을 지속적으로 돌연변이시키기 위한 범용 앱타머 검색Article Published on 2022-07-052022-09-11 Journal: ChemMedChem [Category] COVID19(2023년), SARS, 변종, [키워드] aptamer binding bioinformatic analysis COVID-19 demonstrated develop diagnostics DNA effort experiment followed by high affinity Mutation overcome pool producing Protein recognize S protein S protein variant SARS-CoV-2 sequence significantly solution specificity spike Spike protein the S protein the spike protein Therapeutics Universal variant variants variants of concern virus VOCs wildtype [DOI] 10.1002/cmdc.202200166 PMC 바로가기 [Article Type] Article
Antibodies from convalescent plasma promote SARS-CoV-2 clearance in individuals with and without endogenous antibody response회복기 혈장의 항체는 내인성 항체 반응이 있거나 없는 개인에서 SARS-CoV-2 제거를 촉진합니다Clinical Trial Published on 2022-06-152022-09-11 Journal: The Journal of Clinical Investigation [Category] COVID19(2023년), MERS, SARS, 임상, 진단, 치료기술, [키워드] 95% CI absence Adaptive immunity adjusted hazard ratio adverse events affected antibody Antibody Response clearance Clinical research Comorbidity Comprehensive conducted convalescent plasma Convalescent plasma therapy Corona COVID-19 Critical demonstrated disease status Efficacy evidenced faster hazard ratio hospitalized COVID-19 patient human infection human infections Immunotherapy individual Innovation Intervention IQR Kaplan-Meier analysis laboratory parameter median interval Mortality neutralization Neutralizing neutralizing antibody onset of symptom parameter Phase I plasma plasma therapy pool principle priority Program promote recipient recipients Red respond Safe SARS-CoV-2 SARS-CoV-2 antibodies SARS-CoV-2 clearance SARS-CoV-2 vaccines serological significantly survival therapeutic Therapeutics therapy transfusion-related adverse event transfusion-related adverse events Trial university University of Zurich Viral viral clearance Viral load Viremia Virological virus clearance [DOI] 10.1172/JCI158190 PMC 바로가기 [Article Type] Clinical Trial
Targeted Virome Sequencing Enhances Unbiased Detection and Genome Assembly of Known and Emerging Viruses-The Example of SARS-CoV-2표적 바이롬 시퀀싱은 알려진 바이러스와 새로 출현하는 바이러스의 편견 없는 탐지 및 게놈 조립을 향상시킵니다-SARS-CoV-2의 예Article Published on 2022-06-112022-09-11 Journal: Viruses [Category] COVID19(2023년), SARS, 치료기술, 치료제, [키워드] Adenovirus assembly cDNA cDNA synthesis characterization coronavirus COVID-19 coxsackievirus cytomegalovirus depleting detection Detection sensitivity DNA and RNA dsDNA Efficiency emerging viruses equimolar evaluate followed by genetic diversity genome assembly genomic H3N2 Illumina Influenza influenza A influenza A virus less mapped Nanopore nanopore sequencing NGS NGS diagnostics OC43 pathogen Pathogens point-of-care pool positive sample proof remained respiratory syncytial virus RNA virus RNA viruses SARS-CoV-2 sequence Sequencing strain Strains synthesis target enrichment total read viral genomes virome sequencing. virus viruses was performed [DOI] 10.3390/v14061272 PMC 바로가기 [Article Type] Article
Performance of the TaqMan COVID-19 Pooling Kit for detection of SARS-CoV-2 in asymptomatic and symptomatic populations무증상 및 유증상 집단에서 SARS-CoV-2 검출을 위한 TaqMan COVID-19 풀링 키트의 성능Article Published on 2022-06-102022-09-11 Journal: PLoS ONE [Category] COVID19(2023년), SARS, 치료기술, 치료법, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Algorithm analytical sensitivity applicability Asymptomatic Asymptomatic case Asymptomatic cases Asymptomatic COVID-19 Chain Reaction China clinical clinical evidence Cohort cohorts coronavirus coronavirus disease COVID-19 curated demonstrated detect effective Evidence expected FIVE Frame gold gold standard higher education independent t-test labor lack nare nucleocapsid Open reading frame ORF ORF1ab P-value p-values pandemic PCR testing performance performed polymerase chain polymerase chain reaction pool pooling Population positive sample Prevalence Qualitative reported resource reverse transcriptase RNA RT-PCR RT-qPCR SARS-CoV-2 severe acute respiratory syndrome Coronavirus strain supported surveillance testing Swab symptomatic symptomatic and asymptomatic t-test TaqMan transcriptase Volume Wuhan [DOI] 10.1371/journal.pone.0269798 PMC 바로가기 [Article Type] Article
Effective bubble-based testing for SARS-CoV-2 using swab-pooling면봉 풀링을 사용하여 SARS-CoV-2에 대한 효과적인 거품 기반 테스트Article Published on 2022-06-012022-09-11 Journal: Clinical microbiology and infection : the official [Category] COVID19(2023년), SARS, 변종, [키워드] affecting analyzed appearance approach average average size bottlenecks Bubble can be used Capsule children Cluster Contact tracing Containment Corona Corona testing COVID-19 COVID-19 vaccines Effective strategies effective strategy epidemiological hospitals identify individuals Isolation Laboratory lysis buffer obstructed offer Pandemics PCR testing pool pool testing pooling Positive test reducing refusal sampling SARS-CoV-2 sensitivity specificity Swab Swab pooling. swabs tested the disease throughput Transmission Vaccine vaccine production Viral variants [DOI] 10.1016/j.cmi.2022.02.016 PMC 바로가기 [Article Type] Article