Preclinical findings: The pharmacological targets and molecular mechanisms of ferulic acid treatment for COVID-19 and osteosarcoma via targeting autophagyArticle Published on 2022-09-202022-11-15 Journal: Frontiers in Endocrinology [Category] SARS, 변종, 유전자 메커니즘, 진단, [키워드] 2019 coronavirus disease activities acute respiratory disease applied autophagy Bioinformatics analysis characterized clinical coronavirus COVID-19 deficiency determine develop Effectiveness Evidence ferulic acid Genes impacted individuals MAPK1 mechanism mechanisms medication methodology molecular docking molecular docking analysis molecular mechanism network pharmacology number of infected Ontology osteosarcoma pandemic pathway enrichment Patient Patients with cancer pharmacological pharmacological target PIK3R1 Population potential therapeutic target Preclinical Protein regulatory subunit SARS-CoV-2 STAT3 target targets therapeutic therapeutic targets Transcription treat treatment for COVID-19 variant [DOI] 10.3389/fendo.2022.971687 PMC 바로가기
Therapeutic prospects of ceRNAs in COVID-19Article Published on 2022-09-202022-11-15 Journal: Frontiers in Cellular and Infection Microbiology [Category] SARS, 치료제, [키워드] antiviral therapy applied caused Cell ceRNA Chinese circRNA Clinical treatment competing COVID-19 digestive drug effective drug GAS5 help immune Immunotherapy lncRNA Long MALAT1 microRNA miRNA miRNAs NEAT1 New coronavirus noncoding RNA Novel coronavirus patients with COVID-19 potential therapeutic target predict predicted PTEN reproductive Research RNA Safe SARS-CoV-2 Spread therapeutic target therapy TUG1 [DOI] 10.3389/fcimb.2022.998748 PMC 바로가기
Targeting Doublecortin-Like Kinase 1 (DCLK1)-Regulated SARS-CoV-2 Pathogenesis in COVID-19Article Published on 2022-09-142022-11-15 Journal: Journal of Virology [Category] SARS, 치료기술, 치료제, [키워드] Activation amplified amplify analyzed blocked Blood Cell chemokine chronic liver disease Chronic Liver Diseases circulating comorbid disease Comorbidity contribute controls correlated COVID-19 COVID-19 patients Critical cytokine cytokine secretion DCLK1 DDCLK1 decrease disease severity dysregulation expression Factor Factors Gain growth factor hospitalized patient Host Hyperinflammatory response immune Immune cell immune response immunosuppressive in viral in vitro infected cells Inflammation Inflammatory cytokine inflammatory pathway inhibition inhibitor Innate immunity involved kinase Live virus liver livers loss of function lung Lung disease Macrophage mononuclear cell mononuclear cells Mortality neutrophil normalized Pathogenesis pathology Patient Peripheral blood potential therapeutic target Prevalence pro-inflammatory profile proinflammatory promoted promoter Protein S100A9 SARS-CoV-2 SARS-CoV-2-infected cell secretion severity of COVID-19 Signaling subject targeting Treatment Viremia virus production virus replication with COVID-19 β-catenin [DOI] 10.1128/jvi.00967-22 PMC 바로가기
Network Pharmacology and Bioinformatics Analysis Identifies Potential Therapeutic Targets of Paxlovid Against LUAD/COVID-19Article Published on 2022-09-082022-11-16 Journal: Frontiers in Endocrinology [Category] SARS, 유전자 메커니즘, [키워드] acute respiratory syndrome Against Analysis approved bioinformatics caused Clinical characteristics Clinical data contagious coronavirus Coronavirus disease 2019 correlation country COVID-19 COX Cytoscape downloaded drug drug target DrugBank evaluate evaluated Fatality rate FDA Features food functional Gene Expression GeneCards Genes GO enrichment analysis IL-17 IL12B IL6 include infected with COVID-19 Interaction KEGG LBP lung adenocarcinoma (LUAD) lung cancer patient management mechanism modulate molecular molecular docking Mortality NCBI network network pharmacology pandemic pathway Pathway analysis Patient Paxlovid Pharmacology Potential potential therapeutic target Prognosis prognostic receptor Regression model risk SARS-CoV-2 screened signaling pathway survival rate susceptibility SwissTargetPrediction target target gene TargetNet therapeutic target Transcriptome Treatment Venn diagram virus was performed was used while [DOI] 10.3389/fendo.2022.935906 PMC 바로가기
Computational Analysis of Short Linear Motifs in the Spike Protein of SARS-CoV-2 Variants Provides Possible Clues into the Immune Hijack and Evasion Mechanisms of Omicron VariantSARS-CoV-2 변이체의 스파이크 단백질에서 짧은 선형 모티프의 컴퓨터 분석은 Omicron 변이체의 면역 하이잭 및 회피 메커니즘에 대한 가능한 단서를 제공합니다Article Published on 2022-08-082022-09-11 Journal: International Journal of Molecular Sciences [Category] SARS, 변종, 유전자 메커니즘, [키워드] Affect approach binding cellular interaction cellular pathways Coronaviruses COVID-19 eukaryotic facilitate Host host protein host proteins immune functions information interfere intracellular proteins intracellular signaling linear motif motifs omicron potential therapeutic target potential therapeutic targets Protein protein-protein interaction regulate SARS-CoV-2 SARS-CoV-2 variants sequence Sequence analysis significantly SLiMs Spike protein Spike proteins the SARS-CoV-2 the Spike Transmission variant variants viral infection virus [DOI] 10.3390/ijms23158822 PMC 바로가기 [Article Type] Article
Clinical characteristics with inflammation profiling of long COVID and association with 1-year recovery following hospitalisation in the UK: a prospective observational studyObservational Study Published on 2022-08-012022-10-04 Journal: The Lancet. Respiratory Medicine [Category] COVID19(2023년), SARS, 임상, [키워드] age analysed approach association Characteristics clinical Clinical outcome clinical trials Cluster cluster analysis Clustering Clusters Cognitive impairment Cohort comparison Concentration COVID COVID-19 described discharge discharged domains effective Factor female full recovery Health hospital Hospital admission hospital discharge hospitalisation identify IL-6 improvement Inflammation Inflammatory inflammatory mediator Innovation Intervention Invasive mechanical ventilation ISRCTN registry less logistic regression modelling longitudinal cohort study median men mental health Mild moderate obesity Odds ratio organ function outcome measure outcome measures participant Participants Patient pharmacological PHOSP-COVID physical plasma Post-hospitalisation COVID-19 study potential therapeutic target profile proportion prospective observational study Protein Quality of life recruitment Registered reported retrospective severity Sex stratified tissue damage treatable utility was done was increased was performed was reduced were assessed WHO with COVID-19 women [DOI] 10.1016/S2213-2600(22)00127-8 PMC 바로가기 [Article Type] Observational Study
Longitudinal Serum Proteome Characterization of COVID-19 Patients With Different Severities Revealed Potential Therapeutic Strategies다양한 중증도를 가진 COVID-19 환자의 세로 혈청 프로테옴 특성이 잠재적인 치료 전략을 드러냄Article Published on 2022-07-262022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] Activation alteration Analysis Asymptomatic asymptomatic patient asymptomatic patients caused characterization cholesterol cholesterol metabolism Cluster cluster analysis coagulation cascade collected complement Complement activation control group control groups COVID-19 COVID-19 pandemic COVID-19 patient COVID-19 patients disease Disease progression dysregulation effective expand global healthcare heterogeneity Hierarchical hierarchical cluster analysis immune response individuals involved longitudinal metabolism Mild moderate Moderate COVID-19 moderate COVID-19 patients molecular Non-COVID-19 not recovered Pathogenesis pathophysiological Patient patients performed PLGLB1 Potential potential therapeutic target potential therapeutic targets progression Protein Proteins proteomic proteomics restored Revealed SARS-CoV-2 serum serum biomarker serum biomarkers Serum level serum sample serum samples severity Strategy symptomatic Treatment understanding [DOI] 10.3389/fimmu.2022.893943 PMC 바로가기 [Article Type] Article
Exercise-induced myokines downregulates the ACE2 level in bronchial epithelial cells: Implications for SARS-CoV-2 prevention운동 유도 미오카인은 기관지 상피 세포에서 ACE2 수준을 하향 조절합니다: SARS-CoV-2 예방에 대한 의미Article Published on 2022-07-202022-09-11 Journal: PLoS ONE [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] A549 ACE2 angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 animal models applied approach approaches Bronchial epithelium cancer cell line Cell Cell culture cell culture study cell line centrifugation condition conditioned media controls COVID-19 pandemic culture system cytokine Cytokines death rate decrease demonstrated downregulate downregulation Effect ELISA ELISAs enzyme enzyme-linked immunosorbent assay epidemiological studies epithelial exercise exposure to expression form generate highlighting human lung immortalized lung cancer marker mass spectroscopy media mitigate modulating mRNA myokine pandemic Part PCR physical activity potential therapeutic target potential therapeutic targets priming protective effect protein level proteomic Proteomic analysis public health pulse Quantitative quantitative real-time PCR Quantitative RT-PCR receptor reduction remained replicated respiratory viruses rigor risk of infection RT-PCR SARS-CoV-2 sensitivity Serine shown Skeletal muscle skeletal muscles stimulated the SARS-CoV-2 TMPRSS2 TMPRSS2 protein transmembrane serine protease transmembrane serine protease 2 treated Treatment vaccination Vaccinations virulent virus was performed while [DOI] 10.1371/journal.pone.0271303 PMC 바로가기 [Article Type] Article
MicroRNAs in the development of potential therapeutic targets against COVID-19: A narrative reviewReview article Published on 2022-07-012022-10-05 Journal: Journal of infection and public health [Category] COVID19(2023년), SARS, 바이오마커, 변종, 치료제, [키워드] ACE2 ACE2 receptor ACE2 receptors Antiviral biogenesis cellular miRNAs change chemokines collected complex conducted consequence COVID-19 cytokine Cytokines database Degradation Deleterious effective evaluate expression Extensive function generate Google help host response immune system include Infection infection process information inhibiting Interaction involved latency microRNA miRNA miRNAs Modification modulate Pathogenesis platform potential therapeutic target Prognosis reduce reduced regimen Regulation Regulatory Result SARS-CoV-2 SARS-COV-2 infection Science Direct Scientific community secretion Side effects Specific the SARS-CoV-2 therapeutic therapeutic target therapeutic targets Therapeutics therapy threat viral infection Viral load viral replication Viral RNA virus website WHO [DOI] 10.1016/j.jiph.2022.06.012 [Article Type] Review article
Small-molecule metabolome identifies potential therapeutic targets against COVID-19소분자 대사체는 COVID-19에 대한 잠재적인 치료 표적을 식별합니다Article Published on 2022-06-152022-09-12 Journal: Scientific Reports [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, 치료제, [키워드] Accuracy biochemical change characterized composed Concentration controls COVID-19 COVID-19 infected individual COVID19 COVID19 patient disease severity evaluate host cell identify Infection metabolome metabolomic signature microbes nasal nasal mucosa nasopharyngeal Patient potential therapeutic target potential therapeutic targets primer produced qRT-PCR R 2 respiratory respiratory syncytial virus RSV SARS-CoV-2 significantly significantly increased small molecule tested transmitted unique viral infection Viral load virus [DOI] 10.1038/s41598-022-14050-y PMC 바로가기 [Article Type] Article