SARS-CoV-2 E protein: Pathogenesis and potential therapeutic developmentReview Published on 2023-01-112024-09-05 Journal: Biomedicine & pharmacotherapy = Biomédecine & phar [Category] update2024, [키워드] envelope protein life cycle mutations Pathogenesis potential therapy SARS-CoV-2 [DOI] 10.1016/j.biopha.2023.114242 PMC 바로가기 [Article Type] Review
Spike-heparan sulfate interactions in SARS-CoV-2 infectionArticle Published on 2022-10-012022-11-16 Journal: Current opinion in structural biology [Category] COVID19(2023년), SARS, 변종, [키워드] ACE2 ACE2 binding binding biochemical cellular Evolution genetic study glycan highlight Host host cell Infection Interaction potential therapy provide recent required SARS-CoV-2 SARS-COV-2 infection shown Spike protein Spread subsequent the SARS-CoV-2 the spike protein variants [DOI] 10.1016/j.sbi.2022.102439 PMC 바로가기
SARS-CoV-2 neutralizing camelid heavy-chain-only antibodies as powerful tools for diagnostic and therapeutic applicationsArticle Published on 2022-09-142022-11-15 Journal: Frontiers in Immunology [Category] SARS, 변종, 진단, 치료기술, [키워드] antibodies antibody B.1.1.529 B.1.617.2 camelid heavy-chain-only antibodies candidate caused characterized Combination Concentration COVID-19 pandemic Delta detect detection antibody diagnostic diagnostics domain ELISA enzyme-linked immunosorbent assays Evolution expressed FIVE full length IgG2 in vitro naïve nanobodies neutralization neutralized Neutralizing neutralizing capacity omicron Particle performed potential therapy powerful tool Protein pseudotyped Pseudotyped virus SARS-CoV-2 selected shown single domain antibodies. specificity spike the SARS-CoV-2 therapeutic variant variants of concern virus Virus-like particle virus-like particles wildtype [DOI] 10.3389/fimmu.2022.930975 PMC 바로가기
Virtual screening of substances used in the treatment of SARS-CoV-2 infection and analysis of compounds with known action on structurally similar proteins from other virusesArticle Published on 2022-09-012022-11-15 Journal: Biomedicine & pharmacotherapy = Biomédecine & phar [Category] COVID19(2023년), SARS, 치료제, [키워드] added Analysis anti-SARS-CoV-2 applied bibliometric analysis Biomedical research caused Compound COVID-19 pandemic Critical docking drug drugs effective effective drug etiological agent in silico in-silico inhibitors less management molecular docking new virus pandemic potential therapy Prevent Protein Proteins provided reduce researcher resource respiratory SARS-CoV-2 SARS-COV-2 infection shown the disease therapeutic compound Topic Transmissibility Treatment Treatment of SARS-CoV-2 infection Virtual screening virus viruses [DOI] 10.1016/j.biopha.2022.113432 PMC 바로가기
Soluble CD137 as a potential biomarker for severe COVID-19Article Published on 2022-08-012022-10-05 Journal: Immunology letters [Category] 바이오마커, [키워드] 24 hour acute respiratory syndrome Analysis Biomarker Blood Brazil Care caused CD137 characterized Clinical outcome contagious Control coronavirus Coronavirus disease 2019 correlation COVID-19 critical COVID-19 patient Critically ill patient cytokine Cytokines demonstrated disease disease severity evaluate evaluated growth factor Growth factors Health healthy blood donors high risk highly pathogenic hospital ICU ICU admission identify immune increase in increased risk Infection intensive care isoform mechanical ventilation membrane-bound mortality rate Necrosis outcomes pandemic Potential biomarker potential therapy primary endpoint Prospective Study receptor recruitment regulate responsible SARS-CoV-2 severe COVID-19 severe SARS-CoV-2 severity Soluble CD137 Soluble immune checkpoints T-cell activation therapeutic targets TNF was related was used WHO with COVID-19 World Health Organization [DOI] 10.1016/j.imlet.2022.07.003 [Article Type] Article
Cytopathic SARS-CoV-2 screening on VERO-E6 cells in a large-scale repurposing effort대규모 용도 변경 노력에서 VERO-E6 세포에 대한 세포변성 SARS-CoV-2 스크리닝Article Published on 2022-07-132022-09-11 Journal: Scientific Data [Category] COVID19(2023년), SARS, 신약개발, 치료제, [키워드] accelerate anti-inflammatory drug approach Cell Compound COVID-19 COVID-19 disease Dexamethasone Drug discovery drugs effective effort greater highlighting idea identify inhibitor Intensive mechanism Patient patients phenotypic phenotypic screening potential therapies potential therapy reducing mortality Remdesivir repertoire Repurposed drug Repurposed drugs SARS-CoV-2 SARS-COV-2 infection screened shown Support Time to recovery viral infection [DOI] 10.1038/s41597-022-01532-x PMC 바로가기 [Article Type] Article
Intravenous delivery of GS-441524 is efficacious in the African green monkey model of SARS-CoV-2 infectionGS-441524의 정맥내 전달은 SARS-CoV-2 감염의 아프리카 녹색 원숭이 모델에서 효과적입니다Article Published on 2022-07-012022-09-11 Journal: Antiviral Research [Category] COVID19(2023년), SARS, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus administration African African green monkey African green monkeys AGM AGMs alveolar antiviral activity antiviral efficacy antiviral therapy approved assays causative agent coronavirus COVID-19 COVID-19 pandemic determine dose dose-dependent efficacy dosed exhibit FDA green green monkey GS-441524 in vitro in vivo intravenous less Lower respiratory tract lung nucleoside oral bioavailability parent nucleoside plasma plasma concentration plasma concentrations potential therapies potential therapy primary cells RDV reduced reduction Remdesivir required respiratory virus respiratory viruses resulting SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 replication severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 significant reductions significantly higher Support treated Treatment treatment of COVID-19 triphosphate [DOI] 10.1016/j.antiviral.2022.105329 PMC 바로가기 [Article Type] Article
Synergistic Antiviral Activity of Pamapimod and Pioglitazone against SARS-CoV-2 and Its Variants of ConcernSARS-CoV-2 및 우려 변종에 대한 파마피모드 및 피오글리타존의 상승적 항바이러스 활성Article Published on 2022-06-202022-09-11 Journal: International Journal of Molecular Sciences [Category] COVID19(2023년), SARS, 변종, 치료제, [키워드] acting activity agonist Alpha Anti-inflammatory antiviral activity antiviral potency approved Arthritis assumption Beta cell type cellular cellular pathway cellular targets clinical study clinically evaluated Combination components concern coronavirus COVID-19 COVID-19 patients Delta described diabetes drug effective evaluated Gamma in vitro inhibit SARS-CoV-2 inhibitor kinase mitogen mitogen-activated protein kinase molnupiravir omicron p38-inhibitor pamapimod pathway Paxlovid pioglitazone polymerase potential therapy PPRy-agonist Protease inhibitor protein kinase public health threat reduce Replication replication of SARS-CoV-2 rheumatoid arthritis SARS-CoV-2 SARS-CoV-2 pandemic SARS-CoV-2 replication selective Severity of disease small molecule Small molecules Support synergistic These data transmitted treat Treatment type 2 diabetes Vaccine-induced immunity variant variants variants of concern viral replication virulent virus variants VOCs Wuhan [DOI] 10.3390/ijms23126830 PMC 바로가기 [Article Type] Article
Eltrombopag for refractory vaccine-induced immune thrombotic thrombocytopenia난치성 백신에 의한 면역혈전성 혈소판감소증 치료제 엘트롬보팩Case Reports Published on 2022-05-012022-09-12 Journal: Journal of Thrombosis and Thrombolysis [Category] MERS, 진단, [키워드] adenoviral vector administration antibody Antigen ChAdOx1-S characterized complexes conditions Corticosteroids COVID-19 described disorder ELISA Eltrombopag enzyme-linked immunosorbent functional highlight immune Infarction Intravenous immunoglobulin introduced levels of antibody life-threatening management Patient Platelet positive potential therapy renal renal vein reported respiratory SARS-CoV-2 syndrome tested the spike protein thrombocytopenia thrombosis thrombotic vaccine administration Vaccines [DOI] 10.1007/s11239-021-02604-2 PMC 바로가기 [Article Type] Case Reports
Inhaled Placental Mesenchymal Stromal Cell Secretome from Two- and Three-Dimensional Cell Cultures Promotes Survival and Regeneration in Acute Lung Injury Model in Mice2차원 및 3차원 세포 배양에서 흡입된 태반 중간엽 간질 세포 Secretome은 마우스의 급성 폐 손상 모델에서 생존 및 재생을 촉진합니다Article Published on 2022-03-222022-09-11 Journal: International Journal of Molecular Sciences [Category] SARS, 유전자 메커니즘, [키워드] acute lung injury acute respiratory distress acute respiratory distress syndrome acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 administration adult stem cells ALI model ARDS Cell cell spheroids cell-free therapy content coronavirus COVID-19 COVID-19 pandemic cultivation damaged death effective Effectiveness exhibited Extracellular Extracellular vesicles FIBRIN fibroblast healthcare histological immunomodulating in some Inflammatory Inflammatory diseases inhalation Inhaled investigated lung Lung inflammation Lung injury lung surfactant lung tissue Lungs management Measures mice Model morbidity and mortality Mortality Patient placental potential therapy problem proteomic regeneration regenerative respiratory distress Respiratory distress syndrome restored SARS-CoV-2 Secretome severe acute respiratory syndrome Coronavirus severe pneumonia stromal cell surfactant survival syndrome Taking therapeutic tissue regeneration [DOI] 10.3390/ijms23073417 PMC 바로가기 [Article Type] Article