Multi-target mechanisms against coronaviruses of constituents from Chinese Dagang Tea revealed by experimental and docking studies실험 및 도킹 연구를 통해 밝혀진 중국 Dagang Tea 성분의 코로나바이러스에 대한 다중 표적 메커니즘Article Published on 2022-10-282022-09-11 Journal: Journal of ethnopharmacology [Category] COVID19(2023년), SARS, 치료제, [키워드] Analysis antibody antiviral activity Antiviral effect betulinic acid Chemical profile China Chinese Cold colds Compound coronavirus Coronaviruses CPE Cytopathic effect demonstrated docking docking analysis docking study Efficacy enzyme Enzyme inhibition eriodictyol Eurya evaluated exhibited experiment Fever fevers flavonoids Guangdong HCoV-OC43 herbal tea immunofluorescence in vitro infected cells Influenza inhibitory effect Inhibitory effects material mechanism Microscopic monomer naringenin OC43 optical performed PLPro Potential treatment potential treatments Prevent quercetin reduction SARS-CoV-2 tea Traditional Chinese medicine transmission electron microscopy treat Treatment viral infections Virtual screening virus particle virus particles [DOI] 10.1016/j.jep.2022.115528 PMC 바로가기 [Article Type] Article
Serine Protease Inhibitors Restrict Host Susceptibility to SARS-CoV-2 Infections세린 프로테아제 억제제는 SARS-CoV-2 감염에 대한 숙주 감수성을 제한합니다Article Published on 2022-06-282022-09-11 Journal: mBio [Category] COVID19(2023년), SARS, 유전자 메커니즘, 치료제, [키워드] A1AT acute respiratory syndrome Administered Affect affecting age Alpha alpha-1-antitrypsin antithrombin III antitrypsin Antiviral antiviral drug antiviral intervention approach asymptomatic infection asymptomatic infections ATIII can be used cellular cellular protease ciliated cleavage club Comorbidities Comorbidity complex coronavirus disease Coronavirus disease 2019 COVID-19 deficiency determinant determinants disease disease severity Donor door expression expression level Factor Genetic Genetic variation Genetic variations goblet cells highlight Host human donors identification identify identity immune response individual Infection inhibitor inhibitors less lung cell mechanism mechanism of action outcome PAI1 Patient patients plasminogen activator inhibitor 1 Potential potential treatments primary cell primary cells reduce reducing regulate restrict risk risk factor Risk factors SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 susceptibility Serine serine protease serine protease inhibitor serine protease inhibitors serpin serpin. SERPINA1 SERPINE1 SERPINE2 serpins Severe acute respiratory syndrome severe COVID-19 severe infections Sex Single-cell RNA sequencing Spike protein susceptibility susceptible Symptom target cells TMPRSS2 Treatment Usage Variation viral burden viral entry viral spike protein [DOI] 10.1128/mbio.00892-22 PMC 바로가기 [Article Type] Article
Effects of Iranian Polyherbal Syrup (Zufa syrup) on oxygen saturation and clinical symptoms in suspected patients with COVID-19: a triple-blinded, randomized, placebo-controlled trialRandomized Controlled Trial Published on 2022-04-012022-10-05 Journal: Medical gas research [Category] COVID19(2023년), SARS, 임상, [키워드] age anorexia Anxiety approval approved Arm ARMS bypassing caused center Chest computed tomography clinical clinical symptom Combination Cordia Corona Coronavirus disease 2019 COVID-19 dose Dyspnea Effect Efficacy eligibility criteria Ethics ethics committee Evidence Fennel Follow-up headache herbal drug Hospital admission in both groups Insomnia Iran IRIS male Mild moderate myalgia Nepetabracteata no difference offer oxygen saturation pandemic Papaver participant Patient Placebo placebo-controlled trial plant potential treatments Pulse rate Qom Randomized Randomized controlled trial receive recruited reference number Registered required Respiratory disease respiratory infections Science severity of symptoms study period sugar Supplemental oxygen therapy suspected patient symptoms of COVID-19 syrup Traditional Traditional medicine Treatment Trial triple-blind university Viola VIPER were assessed [DOI] 10.4103/2045-9912.325991 PMC 바로가기 [Article Type] Randomized Controlled Trial
Dynamic Changes of the Blood Chemistry in Syrian Hamsters Post-Acute COVID-19급성 COVID-19 이후 시리아 햄스터의 혈액 화학의 동적 변화Research Article Published on 2022-02-232022-09-10 Journal: Microbiology Spectrum [Category] COVID19(2023년), MERS, SARS, 치료기술, [키워드] acute COVID-19 acute respiratory syndrome acute respiratory syndrome coronavirus albumin albumin level albumin levels Blood blood biochemistry blood chemistry blood sample Blood samples cause change changes in Chemistry Clinicians collected consequence coronavirus coronavirus disease Coronavirus disease 2019 Course COVID-19 determine dynamic Effect hamster hamsters Health Histopathology histopathology of the lungs infected with SARS-CoV-2 Infection information inoculated long-term change long-term changes low-density Low-density lipoprotein lung lung damage Lung pathology Lungs Manifestations Mesocricetus moderate moderate to severe multiorgan disease Multiple Novel coronavirus observé pathology Patient Post-infection Potential treatment potential treatments processed Protein provide reported researcher respiratory SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 severe inflammation significantly syndrome total protein Triglyceride uric acid Viral Viral load virus weight loss [DOI] 10.1128/spectrum.02362-21 PMC 바로가기 [Article Type] Research Article
PTSD as an Endothelial Disease: Insights From COVID-19Neuroscience Published on 2021-10-292022-10-31 Journal: Frontiers in Cellular Neuroscience [Category] COVID-19, [키워드] activate affected ANG angiotensin receptor blocker Antigen BDNF Brain cell types cleaving conditions COVID-19 Critical disorder disorders disrupt dysfunction Effect endothelia Endothelial cell endothelial cells enzyme fibrinolytic system furin Host individuals inhibitor inhibitors insight Lactate microvascular permeability Mitochondria mitochondrial molecular NSP6 Orf9b pandemic Pathogenesis pathology Pathways populations Posttraumatic Stress potential treatments Premature Prevalence Psychological PTSD receptor renin-angiotensin system S2 antigen SARS-CoV-2 SARS-CoV-2 virus senescent Stress structures supported survivor susceptibility the SARS-CoV-2 virus therapy trauma Trigger upregulate virus [DOI] 10.3389/fncel.2021.770387 PMC 바로가기 [Article Type] Neuroscience
Long-term survival of mechanically ventilated patients with severe COVID-19: an observational cohort studyResearch Published on 2021-10-022022-10-28 Journal: Annals of Intensive Care [Category] COVID-19, [키워드] 95% CI acute respiratory syndrome administration age ARDS cohort study coronavirus coronavirus disease Coronavirus disease 2019 Corticosteroid COVID-19 develop diabete digestive dosage Factor help Hospital admission Hospital stay hypoxemic ICU ICU admission in-hospital mortality Infection intensive care unit intubation Invasive mechanical ventilation invasive ventilation long-term survival lymphocyte male mechanically ventilated patient median age Methylprednisolone Mortality multicentre nasopharyngeal sample National neutrophil noninvasive noninvasive respiratory Noninvasive ventilation Observational cohort study outcome participant Patient patients with COVID-19 Pneumonia polymerase chain positive positive pressure ventilation potential treatments Predictive Primary outcome Probability Ratio real time Registered Respiratory failure Result risk stratification SARS-CoV-2 secondary selective severe COVID-19 Spain supplementary material Support survival survival rate [DOI] 10.1186/s13613-021-00929-y PMC 바로가기 [Article Type] Research
Transcriptomic Analysis of HCN-2 Cells Suggests Connection among Oxidative Stress, Senescence, and Neuron Death after SARS-CoV-2 InfectionHCN-2 세포의 전사체 분석은 SARS-CoV-2 감염 후 산화 스트레스, 노화 및 신경 세포 사멸 간의 연관성을 시사합니다Article Published on 2021-08-252022-09-11 Journal: Cells [Category] MERS, SARS, 유전자 메커니즘, [키워드] Analysis antioxidant Apoptosis blocking caspase caspase 3 CDK4 CDK6 CDKN2A Cell cell cycle cells cortical cell death decrease deregulation evaluate the effect explain followed by functions HCN-2 impairment increase in indicated KAT5 mechanism nervous system Neurological symptom Neurological symptoms Neuron neuronal neurons outcome oxidative stress pediatric PMAIP1 Potential treatment potential treatments Prevent PROTECT r death reduction reported required resulting ROS homeostasis SARS-CoV-2 SARS-COV-2 infection senescence SOD1 supported the cell Transcriptome transcriptomic analysis TXN upregulation virus western blot Western blot analysis [DOI] 10.3390/cells10092189 PMC 바로가기 [Article Type] Article
A Machine-Generated View of the Role of Blood Glucose Levels in the Severity of COVID-19Public Health Published on 2021-07-282022-10-31 Journal: Frontiers in Public Health [Category] COVID-19, MERS, SARS, [키워드] accelerate ACE2 ACE2 receptor Affect aggravate airways alveolar cells article ASL blood glucose carbohydrates Cell cell damage cell death cells Combination Complication computational modeling Concentration condition COVID-19 Critical care Cytokine storm database diagnostic disease disease severity dysregulated dysregulation Effect elevated Elevation evade Evidence explain facilitate feasibility Glucose glycemia glycemic control Glycolysis glycosylation hyper-inflammation hyperglycemia Hypothesis immune defense inactivation induce Infection infection process infections Inflammation information innate immune system involved Ketogenic diet knowledge Level lung Lungs machine learning model MOST multi-organ failure multiple mechanism pandemic potential treatments progression proportion provide pulmonary inflammatory response Quantitative reached replicate Replication Research risk role SARS-CoV-2 Severe case severe COVID-19 severity subsequent Symptoms tested the cytokine storm the disease the patient the SARS-CoV-2 Thrombotic events treatment strategy View viral infection Viral load virus weakened [DOI] 10.3389/fpubh.2021.695139 PMC 바로가기 [Article Type] Public Health
G6PD distribution in sub-Saharan Africa and potential risks of using chloroquine/hydroxychloroquine based treatments for COVID-19사하라 사막 이남 아프리카의 G6PD 분포 및 COVID-19에 대한 클로로퀸/하이드록시클로로퀸 기반 치료제 사용의 잠재적 위험Article Published on 2021-07-232022-09-10 Journal: The Pharmacogenomics Journal [Category] 변종, 유전자 메커니즘, 임상, 진단, [키워드] African allele frequency Analysis Chloroquine chloroquine/hydroxychloroquine clinical trial clinical trials continent country COVID-19 deficiency Deleterious distribution drug G6PD Genetics research Genotype Glucose Glucose-6-phosphate glucose-6-phosphate dehydrogenase Hydroxychloroquine individual nine potential risk Potential treatment potential treatments Predictive medicine Prevalence significant difference significant differences significant interaction South Africa sub-Saharan Africa Treatment treatments for COVID-19 variant variants Variation whole genome sequence [DOI] 10.1038/s41397-021-00242-8 PMC 바로가기 [Article Type] Article
Platform Randomised trial of INterventions against COVID-19 In older peoPLE (PRINCIPLE): protocol for a randomised, controlled, open-label, adaptive platform, trial of community treatment of COVID-19 syndromic illness in people at higher risk플랫폼 COVID-19에 대한 개입의 무작위 시험 In The old people (PRINCIPLE): 무작위, 통제, 공개, 적응 플랫폼에 대한 프로토콜, 고위험군에서 COVID-19 증후군에 대한 지역사회 치료 시험Article Published on 2021-06-182022-09-11 Journal: BMJ Open [Category] SARS, 임상, [키워드] adaptive addition Azithromycin clinical trial clinical trials collected Community Comorbidities complications conferences Contact Course COVID-19 COVID-19 infection death doxycycline Efficacy Eligible participants Ethical approval Ethics EudraCT evaluate futility General practice Health Service higher risk Hospital admission Hydroxychloroquine illness duration Inclusion Infectious diseases Interim analyses interim analysis Intervention intervention arm IRAS Master protocol modify Not completed Older Open-label outcome outcomes participant peer-reviewed platform Potential treatment potential treatments primary care Probability protocol randomisation randomisation probabilities randomised receive reduce registration number Research Research Ethics Result South study drug Symptom symptomatic Treatment treatments for COVID-19 Trial usual care website [DOI] 10.1136/bmjopen-2020-046799 PMC 바로가기 [Article Type] Article