Cigarette smoke preferentially induces full length ACE2 expression in differentiated primary human airway cultures but does not alter the efficiency of cellular SARS-CoV-2 infectionarticle Published on 2023-03-112024-09-05 Journal: Heliyon [Category] update2024, [키워드] ACE2 Air-liquid interface cigarette smoke extract primary human bronchial epithelial cells SARS-CoV-2 [DOI] 10.1016/j.heliyon.2023.e14383 PMC 바로가기 [Article Type] article
CFTR Modulation Reduces SARS-CoV-2 Infection in Human Bronchial Epithelial CellsCFTR 조절은 인간 기관지 상피 세포에서 SARS-CoV-2 감염을 감소시킵니다Article Published on 2022-04-152022-09-11 Journal: Cells [Category] COVID19(2023년), SARS, 진단, 치료기술, [키워드] ACE-2 analyzed bronchial bronchial cell bronchial epithelial cell bronchial epithelial cells Cell cell lines cells CFTR CFTR inhibitor clone Combination correction COVID-19 cystic fibrosis detectable elicited epithelial cell epithelial cell line epithelial cells evaluated Evidence expressing expression fibrosis flow cytometry Human human bronchial epithelial cells human bronchial epithelial cells. immortalized increased risk Infection inhibited inhibitor involved IOWH-032 Post-infection primary cell primary cells primary human bronchial epithelial cells provide real-time RT-PCR reduced Regulation Replication restored SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 replication SARS-CoV-2 viral particles SARS-CoV-2 virus severe symptom severe symptoms Spread subjects supernatant Therapeutic strategies therapeutic strategy Viral Viral load viral replication was reduced were infected wild-type [DOI] 10.3390/cells11081347 PMC 바로가기 [Article Type] Article
The OM-85 bacterial lysate inhibits SARS-CoV-2 infection of epithelial cells by downregulating SARS-CoV-2 receptor expressionOM-85 박테리아 용해물은 SARS-CoV-2 수용체 발현을 하향 조절하여 상피 세포의 SARS-CoV-2 감염을 억제합니다Article Published on 2022-03-012022-09-11 Journal: The Journal of Allergy and Clinical Immunology [Category] SARS, 비임상, 유전자 메커니즘, [키워드] ACE2 ACE2 protein acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 administration airway airway epithelial cells angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 Bacteria Bacterial bacterial lysate binding bronchial epithelial cells caused Cell cell entry cell interactions cell lines coronavirus disease Coronavirus disease 2019 Coronavirus-2 COVID-19 downregulated downregulating downregulation Effect enzyme epithelial epithelial cell epithelial cell line epithelial cells expression HEK293T cell host cells human airway human epithelial cell human epithelial cells immunomodulating in vitro infect Infection inhibit inhibited Interaction intestinal kidney lentiviral particles lentivirus lung mRNA Multiple OM-85 organ organs Prevent primary bronchial epithelial cells primary human bronchial epithelial cells protease PROTECT Protein Protein binding protein expression pseudotyped lentiviral particles reduce respiratory infections S protein S1 protein safety profile SARS-CoV-2 SARS-CoV-2 cell infection SARS-COV-2 infection SARS-CoV-2 receptor SARS-CoV-2 S SARS-CoV-2 S protein SARS-CoV-2 S1 protein Serine serine 2 Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severity significantly TMPRSS2 Transcription transmembrane transmembrane protease serine 2 treated Treatment were measured [DOI] 10.1016/j.jaci.2021.11.019 PMC 바로가기 [Article Type] Article
Pulmonary Delivery of Aerosolized Chloroquine and Hydroxychloroquine to Treat COVID-19: In Vitro Experimentation to Human Dosing PredictionsCOVID-19를 치료하기 위해 에어로졸 화 클로로퀸 및 하이드 록시 클로로 퀴인의 폐 전달 : 인간 투약 예측에 대한 시험 관내 실험Research Article Published on 2022-02-072022-09-10 Journal: The AAPS Journal [Category] 신약개발, [키워드] Abstract acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 administration aerosol Aerosols bronchial epithelial cell Cell cell viability characterized Chloroquine Clinical significance Concentration concentrations coronavirus COVID-19 delivery dose Dosing drug effective Efficacy electrical resistance epithelial cells evaluated exposure to Human humans Hydroxychloroquine in vitro inhalation Inhaled Local lung lysosomal oral administration PBPK pharmacokinetic pharmacokinetics pharmacological physicochemical property predicted prediction primary human bronchial epithelial cells pulmonary respiratory respiratory tract SARS-CoV-2 severe acute respiratory syndrome Coronavirus significant changes in supplementary material target tissue thermal these compound these compounds tissue Toxicity transepithelial electrical resistance treat viability [DOI] 10.1208/s12248-021-00666-x PMC 바로가기 [Article Type] Research Article
A Photoactivable Natural Product with Broad Antiviral Activity against Enveloped Viruses, Including Highly Pathogenic Coronaviruses고도로 병원성 코로나 바이러스를 포함하여 포집 바이러스에 대한 광범위한 항 바이러스 활성을 갖는 광 활성화 가능한 천연 제품Antiviral Agents Published on 2021-11-222022-09-10 Journal: Antimicrobial Agents and Chemotherapy [Category] 치료제, [키워드] active against activity acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Antiviral antiviral activity Antiviral agents broad-spectrum antiviral broad-spectrum antivirals bronchial epithelial cells Cell fusion coronavirus CoV replication CoV-229E COVID-19 COVID-19 therapy CoVs Cryoelectron microscopy demonstrated described Disinfection epithelial cells highly active human CoV Including inhibit inhibitor mechanism of action MERS MERS-CoV Microscopy Middle East Middle East respiratory syndrome Middle East respiratory syndrome Coronavirus natural natural antiviral natural product outbreak primary human bronchial epithelial cells product reduced Replication respiratory respiratory syndrome coronavirus SARS-CoV-2 severe acute respiratory syndrome Coronavirus shown therapy Viral viral membrane viral particle virucidal virus virus entry viruses [DOI] 10.1128/AAC.01581-21 PMC 바로가기 [Article Type] Antiviral Agents
Interferon-Lambda Intranasal Protection and Differential Sex Pathology in a Murine Model of SARS-CoV-2 InfectionSARS-CoV-2 감염의 쥐 모델에서 인터페론-람다 비강 내 보호 및 차등 성 병리학Research Article Published on 2021-11-022022-09-10 Journal: mBio [Category] MERS, SARS, 변종, 치료제, [키워드] ACE-2 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Administered angiotensin Antiviral antiviral agent blocked bronchial epithelial cell can be used coronavirus COVID-19 Culture decrease disease dissemination dose early stage early stages Efficacy enzyme epithelial cells expressing human Angiotensin-converting enzyme Human angiotensin-converting enzyme 2 human lung cell human lung cells IFN-λ infected with SARS-CoV-2 Infection Infectious virus inhibit SARS-CoV-2 inhibited interferon Interferon lambda intranasally Lung infection male mice Model morbidity and mortality Mortality mouse model murine model outcome Pathogens pathology Patient primary human bronchial epithelial cells protection protective effect Protective effects reduce respiratory SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome Coronavirus severe symptom Sex significantly tested transgenic mice treat Treatment Viral viral pathogen viral pathogens virus production [DOI] 10.1128/mBio.02756-21 PMC 바로가기 [Article Type] Research Article
A Potential Role of the CD47/SIRPalpha Axis in COVID-19 PathogenesisCovid-19 병인에서 CD47/Sirpalpha 축의 잠재적 역할Article Published on 2021-09-222022-08-31 Journal: Curr Issues Mol Biol [Category] SARS, 바이오마커, 유전자 메커니즘, 진단, [키워드] Acute kidney injury addressed Air-liquid interface antibody Antiviral antiviral therapy Asymptomatic axis binding bronchial epithelial cells Caco-2 Caco-2 cells Calu calu-3 cells Cancer caused CD47 condition contribute contributing to coronavirus coronavirus SARS-CoV-2 COVID-19 COVID-19 pandemic COVID-19 pathology COVID-19 research COVID-19-related complication COVID-19-related complications Culture develop diabete diabetes disease elevated epithelial cells expression Factor fibrosis fraction group hyperinflammation hypertension IAP Immune escape immune response increase indicated individual infected cells infected individual infected individuals life-threatening Lung fibrosis mechanism Mild Monocytes MOST myocardial injury Older age Potential primary human bronchial epithelial cells primary human monocytes pulmonary hypertension Research resulting risk factor role SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 infections SARS-CoV-2-infected individual SARS-CoV-2-infected individuals severe COVID-19 severe disease SIRPalpha Small molecules stroke therapeutic target vascular disease vasoconstriction virus-infected cells [DOI] 10.3390/cimb43030086 PMC 바로가기 [Article Type] Article
Distribution of ACE2, CD147, CD26, and other SARS-CoV-2 associated molecules in tissues and immune cells in health and in asthma, COPD, obesity, hypertension, and COVID-19 risk factors건강 및 천식, COPD, 비만, 고혈압 및 COVID-19 위험 요소의 조직 및 면역 세포에서 ACE2, CD147, CD26 및 기타 SARS-CoV-2 관련 분자의 분포Article Published on 2020-11-012022-08-31 Journal: Allergy [Category] SARS, 바이오마커, 유전자 메커니즘, 치료제, [키워드] ACE2 Adults age Altered analyzed Asthma atopic dermatitis B cells BAL Blood BMI bronchial epithelial cells Bronchoalveolar lavage fluid BSG caused CD147 CD26 CD4 CD8 clinical presentation co-expression coexpressed Comorbidity contribute COPD correlated COVID-19 COVID-19 children database DCs disease disease status DPP4 epithelial epithelial cells expression expression profile Factor Gender Gene Expression Health healthy children healthy subject healthy subjects human cell human cells hypertension Immune cell immune cells Infection involved lung male material molecular Monocytes mononuclear cell mononuclear cells morbidity Mortality Neutrophils NK cells Novel coronavirus novel coronavirus SARS-CoV-2 obesity Patient PBMC PBMCs performed Peripheral blood Peripheral blood mononuclear cells plasmablasts PPIA PPIB primary human bronchial epithelial cells primary human cell primary human cells receptor reported risk factor Risk factors RNA sequencing SARS receptor SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 receptor SARS-CoV-2 receptors severity skin skin biopsies smoking T cell T cells the disease the SARS-CoV-2 tissue tissues TMPRSS2 were expressed Whole blood [DOI] 10.1111/all.14429 PMC 바로가기 [Article Type] Article