When the Dust Has Settled: Calculation of Binding Affinities from First Principles for SARS-CoV-2 Variants with Quantitative AccuracyArticle Published on 2022-10-112022-11-16 Journal: Journal of chemical theory and computation [Category] COVID19(2023년), SARS, 변종, [키워드] Accuracy ACE2 active against acute respiratory syndrome affinity angiotensin-converting enzyme 2 antibodies antibody applied Beta binding binding free energy biological processe calculation complex coronavirus coronavirus disease Delta delta variant Diversity dust effective estimate host cell Immune escape immune response information methodology molecular omicron Perspective Predictive principle receptor robust SARS-CoV-2 Support the binding affinity the receptor-binding domain Therapies Transmissibility variant variants widespread wild type [DOI] 10.1021/acs.jctc.2c00604 PMC 바로가기
Translational feasibility and efficacy of nasal photodynamic disinfection of SARS-CoV-2SARS-CoV-2의 비강 광역학 소독의 번역 타당성 및 효능Clinical Trial Published on 2022-08-242022-09-11 Journal: Scientific Reports [Category] SARS, 변종, 임상, 치료법, [키워드] Antiviral treatment Bacterial Betacoronavirus clinical trial contributed COVID-19 dependent on early stage early stages Effect effective Effective vaccines Efficacy feasibility global pandemic human betacoronavirus in vitro in vitro result in vitro results inactivation Infection investigated lack Local Methylene Methylene blue nare nares nasal not dependent OC43 Pathogens Perspective photodynamic therapy practicality principle qPCR Quantitative reduce RNA RT-qPCR Safe SARS-CoV-2 SARS-CoV-2 viral load Swab therapeutic option therapeutic options therapy undetectable variants variety viral infectivity viral pathogen viral pathogens Viral RNA virus was reduced [DOI] 10.1038/s41598-022-18513-0 PMC 바로가기 [Article Type] Clinical Trial
Improved SARS-CoV-2 sequencing surveillance allows the identification of new variants and signatures in infected patients향상된 SARS-CoV-2 시퀀싱 감시를 통해 감염된 환자의 새로운 변이체 및 서명 식별 가능Article Published on 2022-08-122022-09-11 Journal: Genome Medicine [Category] SARS, 변종, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition Analysis applied approach Automation B.1 Campania cohorts of patients collected coronavirus correlated COVID-19 pandemic Disease progression Efficacy gain-of-function gene expression signature generate genetic variability Genome genomic Genomic surveillance highest Host host gene expression identify immune protection Improved increase in infected patient Infection Italy lab limit Metadata MONITOR Mutation nasal swab nasal swabs pandemic Patient premises principle producing prognostic biomarker Prognostic biomarkers reconstructed respiratory epithelium reverse transcribed RNA Sample SARS-CoV-2 SARS-CoV-2 genome sequence SARS-CoV-2 genome sequences SARS-COV-2 infection SARS-CoV-2 sequencing scrutiny sequence sequenced sequences severe acute respiratory syndrome Coronavirus Spread Surveillance Transcriptome Treatment upper respiratory Vaccination strategies Vaccination strategy Variability variant variants of concern viral genome Viral genome sequencing viral genomes Viral load viral variant virus VoC was performed [DOI] 10.1186/s13073-022-01098-8 PMC 바로가기 [Article Type] Article
Clinical grade ACE2 as a universal agent to block SARS-CoV-2 variantsSARS-CoV-2 변종을 차단하는 범용 약제로서의 임상 등급 ACE2Article Published on 2022-08-082022-09-11 Journal: EMBO Molecular Medicine [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] ACE2 Alpha analyzed Beta binding affinity caused clinical clinical trial COVID-19 Delta develop Efficacy epithelial cell epithelial cells Gamma human lung human lung epithelial cells independent Infection inhibit inhibited neutralized neutralizing antibody omicron Phase 2 principle proof reduced SARS-CoV-2 isolates SARS-CoV-2 variant SARS-CoV-2 variants several variant several variants soluble ACE2 strain tested therapeutic Therapeutic strategies therapeutic strategy These data Treatment Vaccine variants variants of concern VeroE6 cell VeroE6 cells VoC [DOI] 10.15252/emmm.202115230 PMC 바로가기 [Article Type] Article
Numb-associated kinases are required for SARS-CoV-2 infection and are cellular targets for antiviral strategies마비 관련 키나아제는 SARS-CoV-2 감염에 필요하며 항바이러스 전략의 세포 표적입니다Article Published on 2022-08-012022-09-11 Journal: Antiviral Research [Category] COVID19(2023년), SARS, 치료제, [키워드] AAK1 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 antiviral strategy approach approaches approved caused cellular combination treatment coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 demonstrated drugs epithelial cells Erlotinib experiment expression functional GAK Genetic global health Health Host-targeted antivirals human lung human lung epithelial cells implication in vitro inhibited kinase kinase inhibitors kinases late stage life cycle multiple RNA viruses Numb Numb-associated kinases other coronaviruses pandemic pharmacological principle probe reported required SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 infection in vitro SARS-CoV-2 life cycle SARS-CoV-2 pseudovirus severe acute respiratory syndrome Coronavirus siRNA small molecule STK16 sunitinib suppressed synergistic synergistic effect target the SARS-CoV-2 threat treat viral entry wild type [DOI] 10.1016/j.antiviral.2022.105367 PMC 바로가기 [Article Type] Article
Finding Asymptomatic Spreaders in a COVID-19 Transmission Network by Graph Attention NetworksGraph Attention Networks를 통해 COVID-19 전송 네트워크에서 무증상 전파자 찾기Article Published on 2022-07-282022-09-11 Journal: Viruses [Category] COVID19(2023년), SARS, 치료기술, [키워드] approach Asymptomatic asymptomatic infections asymptomatic spreader Attention catch COVID-19 COVID-19 epidemic COVID-19 transmission COVID-19 transmission network dataset Effectiveness Epidemic finding gene sequence generate Genetic graph graph attention network graph context loss function. help individual Infection information Local loss function mutate natural language natural language processing network preventive measure preventive measures principle RNA virus SARS-CoV-2 sequence spreader spreads symptomatic and asymptomatic Transmission virus [DOI] 10.3390/v14081659 PMC 바로가기 [Article Type] Article
Antibodies from convalescent plasma promote SARS-CoV-2 clearance in individuals with and without endogenous antibody response회복기 혈장의 항체는 내인성 항체 반응이 있거나 없는 개인에서 SARS-CoV-2 제거를 촉진합니다Clinical Trial Published on 2022-06-152022-09-11 Journal: The Journal of Clinical Investigation [Category] COVID19(2023년), MERS, SARS, 임상, 진단, 치료기술, [키워드] 95% CI absence Adaptive immunity adjusted hazard ratio adverse events affected antibody Antibody Response clearance Clinical research Comorbidity Comprehensive conducted convalescent plasma Convalescent plasma therapy Corona COVID-19 Critical demonstrated disease status Efficacy evidenced faster hazard ratio hospitalized COVID-19 patient human infection human infections Immunotherapy individual Innovation Intervention IQR Kaplan-Meier analysis laboratory parameter median interval Mortality neutralization Neutralizing neutralizing antibody onset of symptom parameter Phase I plasma plasma therapy pool principle priority Program promote recipient recipients Red respond Safe SARS-CoV-2 SARS-CoV-2 antibodies SARS-CoV-2 clearance SARS-CoV-2 vaccines serological significantly survival therapeutic Therapeutics therapy transfusion-related adverse event transfusion-related adverse events Trial university University of Zurich Viral viral clearance Viral load Viremia Virological virus clearance [DOI] 10.1172/JCI158190 PMC 바로가기 [Article Type] Clinical Trial
Chemical profiling and unraveling of anti-COVID-19 biomarkers of red sage (Lantana camara L.) cultivars using UPLC-MS/MS coupled to chemometric analysis, in vitro study and molecular docking화학 측정 분석, 시험관 내 연구 및 분자 도킹과 결합된 UPLC-MS/MS를 사용하여 레드 세이지(Lantana camara L.) 품종의 항-COVID-19 바이오마커의 화학적 프로파일링 및 해명Article Published on 2022-06-122022-09-11 Journal: Journal of ethnopharmacology [Category] COVID19(2023년), SARS, 바이오마커, 유전자 메커니즘, 치료기술, 치료제, [키워드] (RdRp acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Analysis anti-COVID-19 activity. antiviral activity approach Asia Biomarker Biomarkers Brazil Candidates Chain Reaction Chemical chemometrics Compound Concentration coronavirus COVID-19 cytotoxicity Data analysis detect determine docked docking docking score E-gene Effect Efficacy except for exhibited exhibiting expression expression levels flavonoids flower followed by highest in vitro study In-vitro India infections inhibitor inhibitory activity interaction pattern Kenya Lantana Lantana camara L. cultivars leprosy Luteolin material mechanism metabolites metabolomics molecular docking multivariate Multivariate analysis Nigeria PCA PCA plot PCA plots plaque polymerase chain polymerase chain reaction principle profile progressed RdRP RdRp gene real-time RT-PCR Red Remdesivir required respiratory respiratory diseases respiratory virus respiratory viruses reverse transcription polymerase chain reaction rheumatism RNA-dependent RNA polymerase RT-PCR SARS-CoV-2 selectivity indices severe acute respiratory syndrome Coronavirus Spread spreading Structure sunset TaqMan target tested Transcription UPLC UPLC-MS/MS Verbenaceae Viral [DOI] 10.1016/j.jep.2022.115038 PMC 바로가기 [Article Type] Article
Clinical trial registration during COVID-19 and beyond in the African context: what have we learned?아프리카 상황에서 COVID-19 동안과 그 이후의 임상 시험 등록: 우리는 무엇을 배웠습니까?Article Published on 2022-06-062022-09-11 Journal: Trials [Category] 임상, [키워드] activity African change clinical Clinical research clinical trial clinical trial registries collaboration conducted country COVID-19 COVID-19 pandemic COVID-19 research Critical disease Hope impacted indicate Infectious disease Intervention offered outbreak pandemic Perspective poverty principle protocol protocols publication bias Registered Registration registries registry Research researchers Transparency Treatment Trial Trial registration [DOI] 10.1186/s13063-022-06412-8 PMC 바로가기 [Article Type] Article
Cytoplasmic domain and enzymatic activity of ACE2 are not required for PI4KB dependent endocytosis entry of SARS-CoV-2 into host cellsSARS-CoV-2의 숙주 세포 내로의 PI4KB 의존성 세포내이입 진입에는 ACE2의 세포질 도메인 및 효소 활성이 필요하지 않습니다Article Published on 2022-06-012022-09-11 Journal: Virologica Sinica [Category] COVID19(2023년), SARS, 변종, [키워드] ACE2 addition angiotensin angiotensin converting enzyme angiotensin converting enzyme 2 Angiotensin converting enzyme 2 (ACE2) catalytic activity causative agent Cell cellular cellular entry cellular receptor clathrin Clathrin-mediated endocytosis COVID-19 pandemic delta variant demonstrated dependent on domain effective endocytosis entry of SARS-CoV-2 enzymatic activity enzyme health emergency host cell host cells human angiotensin converting enzyme 2 infections intracellular domain lentivirus Phosphoinositides PI4KB predominant principle pseudotype required SARS-CoV-2 Spike protein syncytium syncytium formation treat variant viral entry virus entry [DOI] 10.1016/j.virs.2022.03.003 PMC 바로가기 [Article Type] Article