Aqueous cannabidiol β-cyclodextrin complexed polymeric micelle nasal spray to attenuate in vitro and ex vivo SARS-CoV-2-induced cytokine stormsArticle Published on 2023-05-122024-09-05 Journal: International journal of pharmaceutics [Category] update2024, [키워드] β-cyclodextrin cannabidiol Nasal spray solution Polymeric micelles pro-inflammatory cytokine SARS-CoV-2 [DOI] 10.1016/j.ijpharm.2023.123035 PMC 바로가기 [Article Type] Article
Lycopene: a therapeutic strategy against coronavirus disease 19 (COVID- 19)Review Published on 2022-12-012023-07-10 Journal: Inflammopharmacology [Category] COVID19(2023년), [키워드] COVID-19 immune response Lycopene oxidative stress pro-inflammatory cytokine [DOI] 10.1007/s10787-022-01061-4 PMC 바로가기 [Article Type] Review
CD169-mediated restrictive SARS-CoV-2 infection of macrophages induces pro-inflammatory responsesArticle Published on 2022-10-242022-11-15 Journal: PLoS Pathogens [Category] COVID19(2023년), SARS, 치료기술, 치료제, [키워드] ACE2 activated Activation alleviate Antigen CD169 CD169+ macrophage contribute COVID-19 pathology COVID-19 patients de novo elicited exogenous ACE2 expression expression of SARS-CoV-2 facilitated genomic humans Hyperinflammatory IL-1β IL-6 independent induce Infection innate immune response Macrophage macrophages MDA-5 monocyte myeloid cell Post-mortem primary target cell pro-inflammatory cytokine pro-inflammatory response Remdesivir Replication Restricted RIG-I RNA SARS-CoV-2 SARS-CoV-2 entry SARS-COV-2 infection subgenomic RNA subsequent suppressed the SARS-CoV-2 thought TNFα Treatment viral particle Viral protein Viral RNA [DOI] 10.1371/journal.ppat.1010479 PMC 바로가기
The TLR-NF-kB axis contributes to the monocytic inflammatory response against a virulent strain of Lichtheimia corymbifera, a causative agent of invasive mucormycosisArticle Published on 2022-10-132022-11-15 Journal: Frontiers in Immunology [Category] 진단, [키워드] 24 hours activated Activation Apoptosis apoptotic cascade caused Cell cell damage characterized contribute COVID-19 CTLs Cytokines Diabetes Mellitus Diagnosis Diseases ENhance exhibit fungal Fungal infection fungi Hematological malignancies host cell Host immune response host inflammatory response host-pathogen interactions human monocyte human monocytes IL-1β IL-6 increase in individual Infection Inflammatory Inflammatory response inflammatory signaling Interaction invasive killing life-threatening modulation monocyte mortality rate Mucorales Mucormycosis NF-kB Occurrence organ pathogenic phagocyte phagocytosis priming pro-inflammatory cytokine produced progression PRRs receptor receptors regulate secreted signaling pathway spore susceptible synergistic therapy TLR TLR4 TLRs TNF-α Toll-like receptor transcription factor virulent [DOI] 10.3389/fimmu.2022.882921 PMC 바로가기
A comparative study of spike protein of SARS-CoV-2 and its variant Omicron (B.1.1.529) on some immune characteristicsArticle Published on 2022-10-122022-11-15 Journal: Scientific Reports [Category] COVID19(2023년), SARS, 변종, 치료제, [키워드] abrogated activate activated affected antibody Antigen antigenic Antiviral B.1.1.529 binding ability Breakthrough infection comparable complement domain Effects epitope immune characteristics indicated induce inflammatory reaction macrophages molecular Mutation NF-κB nuclear omicron pathogen-associated molecular pathogenicity pro-inflammatory pro-inflammatory cytokine raise receptor S-protein SARS-CoV-2 Spike protein TAK-242 the vaccine Transmissibility trimer variant wild type [DOI] 10.1038/s41598-022-21690-7 PMC 바로가기
Galectin-3 binding protein stimulated IL-6 expression is impeded by antibody intervention in SARS-CoV-2 susceptible cell linesArticle Published on 2022-10-112022-11-15 Journal: Scientific Reports [Category] COVID19(2023년), SARS, 진단, [키워드] Activation affected antibody binding cell line cell types Colon contribute COVID-19 COVID-19 patients described disease epithelial expression galectin-3 global pandemic identify IL-6 IL-6 expression inflammatory cells Intervention lung epithelial marker monoclonal antibody pathophysiology pro-inflammatory cytokine Protein receptor Research SARS-CoV-2 severe cases severe COVID-19 patients severe disease severity stimulate stimulated susceptible cell the cytokine storm therapeutic targets Treatment was reduced [DOI] 10.1038/s41598-022-20852-x PMC 바로가기
Small-molecule screening identifies Syk kinase inhibition and rutaecarpine as modulators of macrophage training and SARS-CoV-2 infectionArticle Published on 2022-10-042022-11-16 Journal: Cell Reports [Category] COVID19(2023년), SARS, 변종, [키워드] acute respiratory syndrome chromosomal Compound coronavirus Coronavirus infection CP: Immunology Effect Effects highlighting human macrophages identify induce influenza A inhibit inhibitor innate immune innate immune training LPS LPS tolerance Macrophage memory modulate modulation Necrosis NFAT-2 OC43 pro-inflammatory cytokine pro-inflammatory cytokines promote promoter prophylactic treatment reported rutaecarpine. SARS-CoV-2 SARS-COV-2 infection secretion small molecule susceptibility Syk inhibition TNF Tolerance Topology variant [DOI] 10.1016/j.celrep.2022.111441 PMC 바로가기
Blood Endothelial-Cell Extracellular Vesicles as Potential Biomarkers for the Selection of Plasma in COVID-19 Convalescent Plasma TherapyArticle Published on 2022-10-042022-11-15 Journal: Cells [Category] 바이오마커, [키워드] Activation age anti-SARS-CoV-2 antibody Biomarkers Blood blood endothelium cardiovascular disease caused CCP CCP therapy Characteristics characterized clinical symptom Concentration consequence convalescent plasma Convalescent plasma therapy coronavirus disease COVID-19 death Donor downregulation Endothelial cell Endothelial dysfunction Endothelium evidenced excessive inflammation expected extracellular vesicle Extracellular vesicles extracellular vesicles. hospital ICAM1 identify individual infected individual inflammatory storm massive secretion mechanism mild symptoms mitochondrial dysfunction multi-organ failure onset of symptom overexpression parameter Peripheral blood plasma Potential pro-inflammatory pro-inflammatory cytokine progression promoted reflected selected Selection severity subset Symptoms the disease therapy vaccination Vascular endothelium vascular inflammation vessel was increased [DOI] 10.3390/cells11193122 PMC 바로가기
Innate Immune Response and Inflammasome Activation During SARS-CoV-2 InfectionArticle Published on 2022-10-012022-11-15 Journal: Inflammation [Category] COVID19(2023년), SARS, 변종, 진단, 치료제, [키워드] Activation Antiviral characterized Clinical outcome COVID-19 COVID-19 outbreak Defense develop drug Effect evade flexibility Genome human pathogen IL-18 IL-1β IL-6 immune immune response immunopathology implicated IMPROVE Infection infective Inflammasome inflammasome pathway inflammatory disease inhibiting Innate innate immune response innate immune system interferon Intervention mutant strain NLRP3 novel coronavirus SARS-CoV-2 pandemic pathology Predictive preventive measure pro-inflammatory cytokine promote protective role public health receptor Replication response responsible RNA virus SARS-CoV-2 SARS-COV-2 infection SARS-CoV2 shown the interferon treating COVID-19 Trigger urgent investigation Vaccine vaccine candidate vaccine candidates vaccine for COVID-19 viral disease viral evolution virus viruses [DOI] 10.1007/s10753-022-01651-y PMC 바로가기
Reactogenic sleepiness after COVID-19 vaccination. A hypothesis involving orexinergic system linked to inflammatory signalsReview article Published on 2022-10-012022-10-05 Journal: Sleep medicine [Category] COVID19(2023년), SARS, 바이오마커, [키워드] Activation addition adverse event Compliance Coronavirus disease 2019 COVID-19 COVID-19 vaccination COVID-19 vaccine COVID-19 vaccines Critical disease manifestation global healthcare Healthcare professional Hypothesis IL-1β Immunity IMPROVE INF-γ Inflammatory inflammatory signal inhibit innate immune system interactions knowledge mechanism morbidity and mortality Narcolepsy Neuron occur Orexin physiological pro-inflammatory cytokine reactogenic reactogenicity Regulation reported Research SARS-COV-2 infection Sickness Side effect Sleep Sleep disturbance Symptom TNF-α vaccination Vaccine while [DOI] 10.1016/j.sleep.2022.06.011 [Article Type] Review article