Optimization of the Prodrug Moiety of Remdesivir to Improve Lung Exposure/Selectivity and Enhance Anti-SARS-CoV-2 ActivityArticle Published on 2022-09-222022-11-15 Journal: Journal of medicinal chemistry [Category] [DOI] 10.1021/acs.jmedchem.2c00758 PMC 바로가기
Pharmacokinetics of ß-d-N4-Hydroxycytidine, the Parent Nucleoside of Prodrug Molnupiravir, in Nonplasma Compartments of Patients With Severe Acute Respiratory Syndrome Coronavirus 2 Infection중증 급성 호흡기 증후군 코로나바이러스 2 감염 환자의 비혈장 구획에서 프로드럭 Molnupiravir의 모체 뉴클레오사이드인 ß-d-N4-Hydroxycytidine의 약동학Clinical Trial Published on 2022-08-242022-09-11 Journal: Clinical Infectious Diseases: An Official Publicat [Category] [DOI] 10.1093/cid/ciac199 PMC 바로가기 [Article Type] Clinical Trial
A stability indicating RP-HPLC method for determination of the COVID-19 drug molnupiravir applied using nanoformulations in permeability studies투과성 연구에서 나노제형을 사용하여 적용된 COVID-19 약물 몰누피라비르의 측정을 위한 안정성을 나타내는 RP-HPLC 방법Article Published on 2022-05-302022-09-11 Journal: Journal of pharmaceutical and biomedical analysis [Category] [DOI] 10.1016/j.jpba.2022.114693 PMC 바로가기 [Article Type] Article
Remdesivir; molecular and functional measures of mitochondrial safety렘데시비르; 미토콘드리아 안전성의 분자 및 기능적 측정Article Published on 2021-12-152022-09-11 Journal: Toxicology and applied pharmacology [Category] [DOI] 10.1016/j.taap.2021.115783 PMC 바로가기 [Article Type] Article
Oral prodrug of remdesivir parent GS-441524 is efficacious against SARS-CoV-2 in ferretsremdesivir 부모 GS-441524의 경구 전구 약물은 흰 족제비에서 SARS-COV-2에 대해 효과적입니다.Article Published on 2021-11-052022-08-31 Journal: Nature Communications [Category] [DOI] 10.1038/s41467-021-26760-4 PMC 바로가기 [Article Type] Article
Emergence of varicella-zoster virus resistance to acyclovir: epidemiology, prevention, and treatmentReview Published on 2021-11-012023-05-31 Journal: Expert review of anti-infective therapy [Category] [DOI] 10.1080/14787210.2021.1917992 PMC 바로가기 [Article Type] Review
Preclinical characterization of an intravenous coronavirus 3CL protease inhibitor for the potential treatment of COVID19COVID19의 잠재적인 치료를 위한 정맥 코로나바이러스 3CL 프로테아제 억제제의 전임상 특성화Article Published on 2021-10-182022-09-10 Journal: Nature Communications [Category] [DOI] 10.1038/s41467-021-26239-2 PMC 바로가기 [Article Type] Article
Why Remdesivir Failed: Preclinical Assumptions Overestimate the Clinical Efficacy of Remdesivir for COVID-19 and Ebola렘데시비르가 실패한 이유: 전임상 가정이 COVID-19 및 에볼라에 대한 렘데시비르의 임상 효능을 과대평가함Article Published on 2021-09-172022-09-11 Journal: Antimicrobial Agents and Chemotherapy [Category] [DOI] 10.1128/AAC.01117-21 PMC 바로가기 [Article Type] Article
A Potent Leukocyte Transmigration Blocker: GT-73 Showed a Protective Effect against LPS-Induced ARDS in Mice강력한 백혈구 변환 차단제 : GT-73은 마우스에서 LPS- 유도 된 ARD에 대한 보호 효과를 나타냈다.Article Published on 2021-07-292022-08-31 Journal: Molecules [Category] [DOI] 10.3390/molecules26154583 PMC 바로가기 [Article Type] Article
Decoding molnupiravir-induced mutagenesis in SARS-CoV-2SARS-CoV-2에서 몰누피라비르 유발 돌연변이 유발 해독Editors' Pick Highlight Published on 2021-06-092022-09-10 Journal: The Journal of Biological Chemistry [Category] [DOI] 10.1016/j.jbc.2021.100867 PMC 바로가기 [Article Type] Editors' Pick Highlight