Hyperbaric oxygen for treatment of long COVID-19 syndrome (HOT-LoCO): protocol for a randomised, placebo-controlled, double-blind, phase II clinical trialArticle Published on 2022-11-022022-11-15 Journal: BMJ Open [Category] SARS, 진단, [키워드] approved assessment baseline Blood Cardiology case sery chronic fatigue syndrome chronic inflammation clinical clinical trial cognitive collected common COVID-19 defined domain double-blind dysfunction Effect effective Efficacy endothelial function Ethics evaluate fatigue healthy subject hyperbaric oxygen hypothese immunology IMPROVE Inconclusive independent individual initial institutional review board Long malaise mechanism monitoring board oxygen Oxygen therapy pandemic Patient peer-reviewed performed physical placebo-controlled placebo-controlled clinical trial positive Potential treatment product protocol Quality of life Questionnaires randomised rehabilitation medicine respiratory medicine (see thoracic medicine) secondary endpoint suggested survey Swedish Symptom syndrome the primary endpoint Treatment Trial VASCULAR MEDICINE. [DOI] 10.1136/bmjopen-2022-061870 PMC 바로가기
In silico evaluation of Philippine Natural Products against SARS-CoV-2 Main ProteaseArticle Published on 2022-10-072022-11-15 Journal: Journal of molecular modeling [Category] COVID19(2023년), SARS, 변종, 치료제, [키워드] Activation acute respiratory syndrome ADME ADMET antiviral drug betweenness Betweenness centrality binding site catalytic dyad Clinical treatment complex coronavirus COVID-19 database docking experiments drugs enzyme highest in silico In silico methods in vitro in vivo inhibitor inhibitory inhibitory effect Ligand molecular docking molecular dynamics MPro mutated variant natural natural products network network analysis offer pandemic Population potential mechanism predicted product protease Protein reported residue responsible risk SARS-CoV-2 SARS-CoV-2. severe COVID-19 Spread the SARS-CoV-2 trajectory Vaccine Vaccines viral replication WHO World Health Organization [DOI] 10.1007/s00894-022-05334-1 PMC 바로가기
Steric accessibility of the N-terminus improves the titer and quality of recombinant proteins secreted from Komagataella phaffiiArticle Published on 2022-09-052022-11-16 Journal: Microbial Cell Factories [Category] SARS, 변종, [키워드] addition addressed aggregation Alpha Amino acid applied benefit caused Cell cleavage cleave demonstrated eliminated extension extracellular space functional Golgi highest Host IMPROVE Modification N-terminal N-terminus observation occur peptide Pichia Pichia pastoris product Product quality protease Protein protein engineering protein sequence Proteins purification Receptor binding domain Recombinant protein recombinant proteins residue Saccharomyces cerevisiae secrete secreted secreted protein secretion signal signal peptide signal peptide. steric steric hindrance subunit the SARS-CoV-2 the signal peptide therapeutic vaccine antigen variant variants [DOI] 10.1186/s12934-022-01905-2 PMC 바로가기
Validation of laboratory developed serology assays for detection of IgG antibody to severe acute respiratory syndrome coronavirus 2 in the South African population남아프리카 인구에서 중증 급성 호흡기 증후군 코로나바이러스 2에 대한 IgG 항체 검출을 위해 실험실에서 개발한 혈청학 분석의 검증Article Published on 2022-09-012022-09-11 Journal: Journal of virological methods [Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 African antibody approved assays authority Beta characterization circulating collected commercial immunoassay Concordance confirmation continent Control coronavirus country Coverage cross-reactive antibodies cut-off value Delta demonstrated described determine diagnostic differentiation ELISA enzyme IFA IgA IgG IgG antibody IgM immunosorbent Infection infection rate investigated Laboratory Laboratory developed lateral flow limit Local mammalian molecular pandemic Patient persistence Population populations positive positive predictive values Predictive predictive values product Quality assurance resource respiratory RT-PCR RT-PCR positive patient SARS-CoV-2 SARS-CoV-2 spike protein sensitivity Serological assay serological assays serology assay serology assays Serology assays. serum sample serum samples severe acute respiratory syndrome Coronavirus shown small sample size South South Africa specificity Spike protein Surveillance tested Vaccine validation variant [DOI] 10.1016/j.jviromet.2022.114571 PMC 바로가기 [Article Type] Article
Decline in antibody responses to SARS-CoV-2 post-vaccination poses a risk to health care workers예방 접종 후 SARS-CoV-2에 대한 항체 반응 감소는 의료 종사자에게 위험을 초래합니다Article Published on 2022-09-012022-09-11 Journal: The Journal of Infection [Category] COVID19(2023년), SARS, 변종, [키워드] Abbreviations: HCW, health care worker Abstract African Antibody Response Care Decline HCW Health Health care Health care worker IGG, immunoglobulin g IGM, immunoglobulin m Immunoglobulin Immunoglobulin G immunoglobulin M interquartile interquartile range IQR IQR, interquartile range lateral flow lateral flow immunoassay LFIA LFIA, lateral flow immunoassay Medical Research Council POC POC, point-of-care product risk SA-MRC, South African Medical Research Council SAHPRA, South African Health Products Authority SARS-CoV-2 South variant VoC VOC, variant of concern. [DOI] 10.1016/j.jinf.2022.06.008 PMC 바로가기 [Article Type] Article
Plasma metabolome and cytokine profile reveal glycylproline modulating antibody fading in convalescent COVID-19 patients혈장 대사체 및 사이토카인 프로필은 회복기 COVID-19 환자에서 글리실프롤린 조절 항체 퇴색을 나타냅니다Article Published on 2022-08-232022-09-11 Journal: Proceedings of the National Academy of Sciences of [Category] SARS, 바이오마커, 진단, [키워드] accumulated Accuracy acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 alteration antibody association catalyzed cleavage conducted convalescent convalescent COVID-19 patient convalescent COVID-19 patients convalescent patient Convalescent patients coronavirus COVID-19 COVID-19 convalescent patients COVID-19 pandemic cytokine cytokine profile cytokine profiling Cytokines demonstrated dipeptide dipeptidyl peptidase Dipeptidyl peptidase 4 domain down-regulate DPP4 experiment feature Feature selection glycylproline healthy healthy subjects IL-12p40 immune response immune responses individual inhibitor inhibitory effect Inhibitory effects M-CSF machine-learning mechanism metabolite metabolites metabolome metabolomics metabolomics. mice modulating neutralizing antibody outcome peptide plasma Plasma cytokine product public health Quantitative respiratory SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 vaccination severe acute respiratory syndrome Coronavirus sitagliptin suppresse therapeutic Treatment vaccination Vaccination strategy with COVID-19 [DOI] 10.1073/pnas.2117089119 PMC 바로가기 [Article Type] Article
Amubarvimab/Romlusevimab: First ApprovalArticle Published on 2022-08-012022-11-15 Journal: Drugs [Category] SARS, 진단, [키워드] acute respiratory syndrome approval approved authorization China Combination coronavirus coronavirus disease COVID-19 COVID-19 in patient death Emergency high risk Hospitalization human IgG1 Mild monoclonal antibody Neutralizing product SARS-CoV-2 severe disease Shenzhen the spike protein Treatment university USA [DOI] 10.1007/s40265-022-01759-3 PMC 바로가기
Neutralizing SARS-CoV-2 Antibodies in Commercial Immunoglobulin Products Give Patients with X-Linked Agammaglobulinemia Limited Passive Immunity to the Omicron VariantArticle Published on 2022-08-012022-11-15 Journal: Journal of Clinical Immunology [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] agammaglobulinemia antibody appear collected Concentration COVID-19 Donor Immunity Immunoglobulin immunoglobulin replacement therapy in vitro individual infections Karolinska University Hospital Limited neutralize neutralizing capacity observation omicron original virus strain pandemic Passive passive immunity Patient plasma plasma concentration Prevent Primary Immunodeficiency product Protective reflect remained Sample SARS-CoV-2 SARS-CoV-2 antibody symptomatic the SARS-CoV-2 therapy unit variant were assessed X-linked agammaglobulinemia X-linked agammaglobulinemia. XLA [DOI] 10.1007/s10875-022-01283-9 PMC 바로가기
In-Silico targeting of SARS-CoV-2 NSP6 for drug and natural products repurposing의약품 및 천연물 용도 변경을 위한 SARS-CoV-2 NSP6의 In-Silico 표적화Article Published on 2022-08-012022-09-11 Journal: Virology [Category] COVID19(2023년), SARS, 신약개발, 치료제, [키워드] African binding binding site candidate Cell Compound compounds COVID-19 crystal structure database docking drug DrugBank Endoplasmic reticulum expansion FDA-approved drug inhibit inhibiting interactions involved molecular dynamics Molecular dynamics simulation molecular dynamics simulations natural natural products. non-structural protein NSP6 pandemic product receptor SARS-CoV-2 SARS-CoV-2 replication screened sigma South Stress stress response targeting [DOI] 10.1016/j.virol.2022.06.008 PMC 바로가기 [Article Type] Article
Surveillance for substandard and falsified medicines by local faith-based organizations in 13 low- and middle-income countries using the GPHF MinilabGPHF Minilab을 사용하여 13개 저소득 및 중간 소득 국가의 현지 신앙 기반 조직에서 표준 이하 및 위조 의약품에 대한 감시Article Published on 2022-07-302022-09-11 Journal: Scientific Reports [Category] MERS, 치료제, [키워드] Analysis API Chloroquine contribute country COVID-19 pandemic deficiency evaluate ingredient International less Local Medicine National organization pandemic product reported screened sensitivity study period substandard Surveillance treatment for COVID-19 WHO [DOI] 10.1038/s41598-022-17123-0 PMC 바로가기 [Article Type] Article