proinflammatory mediator – Communicable Diseases Research

In vitro testing and computational analysis of specific phytochemicals with antiviral activities considering their possible applications against COVID-19

Research article

Published on 2022-02-012022-10-05
Journal: South African Journal of Botany [Category] 신약개발, 치료제,

Coagulation Disorders and Thrombosis in COVID-19 Patients and a Possible Mechanism Involving Endothelial Cells: A Review

Review

Published on 2022-02-012022-10-28
Journal: Aging and Disease [Category] COVID-19,

[키워드] addition adhesion molecules Adults affected angiotensin-converting enzyme 2 antibody Blood Cell cell activation changes in characterized circulation Coagulation coagulation disorder Coagulopathy contribute Coronavirus disease 2019 COVID-19 COVID-19 infection COVID-19 patient COVID-19 patients Critical case D-dimer death disease disorder dysfunction elevated endothelial cells Endothelium Evidence Express higher risk increased risk Inflammation Involving laboratory abnormalities mechanism Mortality nitric oxide Older organ dysfunction outcome pandemic pathophysiological Platelet predict proinflammatory mediator Prothrombin time released Research review SARS-CoV-2 severe cases subendothelial thrombosis tissue upregulation virus
[DOI] 10.14336/AD.2021.0704 PMC 바로가기 [Article Type] Review

Covid-19 and oral diseases: Crosstalk, synergy or association?

코로나19와 구강질환: 누화, 시너지, 연관성?

Review

Published on 2021-11-012022-09-11
Journal: Reviews in Medical Virology [Category] SARS, 유전자 메커니즘,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition Affect alterations angiotensin angiotensin-converting enzyme 2 association Bacterial Blister can not caused clinically cohort study coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patients Crosstalk Cytokines destruction disease Diseases dysfunction elevated Endothelial cell endothelial cells Endotheliitis erythematous Evidence exacerbating exhibit Express facilitate Gingiva gingivitis growth Gustatory Health human body hyperinflammation Immune-mediated impair Infection Infectious disease Inflammation Interaction lesion lesions Loss of Smell loss of smell and taste manifestation mechanism Multiple multiple organ multiple organs necrotic negative and positive oral cavity oral diseases. oral health oral infection oral manifestation oral tissue Pathogenesis Pathogens pathway Patient plaque plaques proinflammatory mediator proinflammatory mediators promote inflammation recent receptor reported salivary salivary gland SARS-CoV-2 severe acute respiratory syndrome Coronavirus Signs and symptoms subject subjects Symptom synergy Taste tissue homeostasis tissue inflammation viral entry viral infection viral replication virus virus spread
[DOI] 10.1002/rmv.2226 PMC 바로가기 [Article Type] Review

Profile of Circulatory Cytokines and Chemokines in Human Coronaviruses: A Systematic Review and Meta-Analysis

Immunology

Published on 2021-05-052022-11-01
Journal: Frontiers in Immunology [Category] COVID-19, MERS,

[키워드] 95% confidence interval activated articles CCL2/MCP-1 Characteristics circulating Circulatory Clinical features Cochrane Library coronavirus disease coronavirus diseases coronavirus strain coronavirus strains COVID-19 COVID-19 patient Cytokine storm database elevated evaluate Genetic highlight homology Human IL-10 IL-6 IL-8 Immune cell immune response immunopathology IMPROVE Increased inflammatory biomarkers Inflammatory cytokine inflammatory cytokine profile Inflammatory cytokines MERS MERS-CoV Meta-analysis observational study outcome phenotype potential therapeutic target profile proinflammatory mediator random-effects model Registration Result review SARS SARS-CoV SARS-CoV-2 screened searched Severe case severe cases severity severity of COVID-19 Severity of infection strain systematic review TNF was performed
[DOI] 10.3389/fimmu.2021.666223 PMC 바로가기 [Article Type] Immunology

Galectin-9, a Player in Cytokine Release Syndrome and a Surrogate Diagnostic Biomarker in SARS-CoV-2 Infection

갈렉틴-9, 사이토카인 방출 증후군의 플레이어이자 SARS-CoV-2 감염의 대리 진단 바이오마커

Comparative Study

Published on 2021-05-042022-08-31
Journal: mBio [Category] SARS, 바이오마커, 치료기술,

[키워드] activated Alpha baseline Biomarker C-reactive protein C-reactive protein (CRP characteristic chemokine chemokines clinical clinical evidence correlation COVID-19 COVID-19 infection COVID-19 patient COVID-19 patients cytokine Cytokine release syndrome Cytokine storm Cytokines diagnostic downregulation Evidence expression Galectin-9 growth factor HCs healthy control healthy controls IL-6 immune activation impacted implicated in vitro indicated individual interleukin interleukin-6 inverse correlation IP-10 MCP-1 MIP-1α monocyte Monocytes Mortality Necrosis neutrophil Neutrophils NK cell NK cells outbreak phenotype plasma positive correlation proinflammatory proinflammatory cytokines proinflammatory mediator proinflammatory mediators receiver operating characteristic Release ROC SARS-CoV-2 SARS-COV-2 infection surrogate TGF-β Therapeutic approach TNF-α transforming growth factor treated Tumor tumor necrosis tumor necrosis factor tumor necrosis factor alpha
[DOI] 10.1128/mBio.00384-21 PMC 바로가기 [Article Type] Comparative Study

SARS-CoV-2: Immune Response Elicited by Infection and Development of Vaccines and Treatments

SARS-CoV-2: 감염 및 백신 및 치료제 개발로 유발되는 면역 반응

Review

Published on 2020-12-112022-09-11
Journal: Frontiers in Immunology [Category] MERS, SARS, 진단, 치료기술, 치료제,

[키워드] acute respiratory syndrome coronavirus addition administration affected antiparasitic antivirals approach approved caused characterized clinical clinical evidence clinical manifestation clinical manifestations Clinical stages clinical trial clinical trials contribute convalescent serum coronavirus coronavirus 2 coronavirus disease COVID-19 COVID-19 disease current therapy deaths described development disease distress drug dry cough effective Evidence exacerbated FDA Fever food Food and Drug Administration headache Health Organization Human Hydroxychloroquine immune Immune cell immune cells immune response immunological imperative Infection Infectious disease information mediators Migration monoclonal antibody monoclonal antibody therapy neutralize organ pandemic Phase III clinical trials potential therapy Prevent proinflammatory mediator proinflammatory mediators respiratory respiratory distress response SARS-CoV-2 SARS-CoV-2 patients severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 Severe case severe cases Symptom tested therapy Treatment treatments Vaccine vaccine candidate Vaccines virus WHO World Health Organization
[DOI] 10.3389/fimmu.2020.569760 PMC 바로가기 [Article Type] Review

Taming the cytokine storm: repurposing montelukast for the attenuation and prophylaxis of severe COVID-19 symptoms

사이토카인 폭풍 길들이기: 심각한 COVID-19 증상의 약화 및 예방을 위한 몬테루카스트 용도 변경

Article

Published on 2020-12-012022-09-11
Journal: Drug discovery today [Category] 신약개발,

[키워드] activated acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 approved Asthma attenuation characterized clinical complication Clinical outcome clinical outcomes coronavirus COVID-19 cytokine cytokine production cytokine profile Cytokine storm decrease Hyperinflammatory immune response infections Inflammation involved mediators modulate Montelukast NF-κB NF-κB activation nuclear Patient proinflammatory mediator proinflammatory mediators Prophylaxis protein complex reduction in respiratory SARS-CoV-2 severe acute respiratory syndrome Coronavirus severe COVID-19 symptom suppress symptom severity Viral viral infections
[DOI] 10.1016/j.drudis.2020.09.013 PMC 바로가기 [Article Type] Article