Proinflammatory response – Communicable Diseases Research

Pigs lacking TMPRSS2 displayed fewer lung lesions and reduced inflammatory response when infected with influenza A virus

Genome Editing Original Research

Published on 2024-05-312024-09-05
Journal: Frontiers in Genome Editing [Category] update2024,

The Mobility of Eurasian Avian-like M2 Is Determined by Residue E79 Which Is Essential for Pathogenicity of 2009 Pandemic H1N1 Influenza Virus in Mice

Article

Published on 2023-11-302024-09-05
Journal: Viruses [Category] update2024,

[키워드] (H1N1)pdm09 influenza M2 NLRP3 pathogenicity Proinflammatory response
[DOI] 10.3390/v15122365 PMC 바로가기 [Article Type] Article

Emerging Role of ZBP1 in Z-RNA Sensing, Influenza Virus-Induced Cell Death, and Pulmonary Inflammation

Z-RNA 감지, 인플루엔자 바이러스 유발 세포 사멸 및 폐 염증에서 ZBP1의 새로운 역할

Review

Published on 2022-06-282022-09-11
Journal: mBio [Category] COVID19(2023년), SARS, 유전자 메커니즘,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Antiviral Apoptosis Cell cell death coronavirus Critical cytopathic death Defense epithelial epithelial cell functional highly pathogenic Host host cell host defense human disease IAV immune sensing immunopathology in vivo Infection Inflammasome Inflammation Inflammatory response Inflammatory responses Influenza influenza A influenza A virus influenza infections influenza viruses Innate Innate immunity Lung infection mechanism necroptosis nucleic acid outbreak Pandemics pathogenic pathogenicity proinflammatory Proinflammatory response promote pulmonary pyroptosis Respiratory illness Respiratory tract infections responses RIPK3 RNA RNA virus role SARS-CoV-2 Signaling triggering understanding viral infections viral strain virus Z-RNA ZBP1 zoonotic transmission
[DOI] 10.1128/mbio.00401-22 PMC 바로가기 [Article Type] Review

Repurposing of Mycobacterium indicus pranii for the severe form of COVID-19 patients in India: A cohort study

Randomized Controlled Trial

Published on 2022-05-012022-10-05
Journal: Journal of medical virology [Category] COVID19(2023년), SARS, 임상,

[키워드] acute respiratory syndrome BST C-reactive protein Chest chest CT scan clinical study cohort study complications Computed tomography conducted consecutive patient Controlled clinical trial coronavirus disease Coronavirus-2 COVID-19 COVID-19 patient Cytokine storm D-dimer levels decreased mortality disease double-blind Efficacy evaluate ferritin hospital India induce infected with SARS-CoV-2 Interleukins Jammu and Kashmir lung abnormality mechanical ventilation MIP Mortality Mycobacterium Mycobacterium indicus pranii normalized offer oxygen saturation placebo-controlled proinflammatory cytokines Proinflammatory response proinflammatory response and oxygen saturation. Randomized reduced reported repurposing restored SARS-CoV-2 severe COVID-19 severe COVID-19 patient significant increase significantly standard treatment Treatment two groups Ventilation
[DOI] 10.1002/jmv.27547 PMC 바로가기 [Article Type] Randomized Controlled Trial

Intrauterine Fetal Demise in the Third Trimester of Pregnancy Associated With Mild Infection With the SARS-CoV-2 Delta Variant Without Protection From Vaccination

예방 접종을 받지 않은 SARS-CoV-2 Delta 변이체의 경증 감염과 관련된 임신 3분기의 자궁 내 태아 사망

Article

Published on 2022-03-022022-09-11
Journal: The Journal of Infectious Diseases [Category] SARS, 변종,

Tocilizumab and COVID-19: Timing of Administration and Efficacy

Pharmacology

Published on 2022-02-182022-10-31
Journal: Frontiers in Pharmacology [Category] COVID-19,

[키워드] “cytokine storm” acute respiratory distress syndrome Admission Concentration Corticosteroids COVID-19 COVID-19 infection COVID-19 pandemic Cytokine storm demonstrated described Effect Efficacy and safety Evidence highlighting Host humanized monoclonal antibody immune immune dysregulation immunomodulatory impairment Infection intensive care intensive care unit interleukin-6 interleukin-6 receptor interleukine -6 receptor antagonist Intervention Invasive mechanical ventilation investigated key factor mechanical ventilation Mortality observational study outcome pathophysiology patients patients with COVID-19 Pneumonia positive result Potential treatment Prognostic factor Proinflammatory response Randomized controlled trial reported risk SARS-COV-2 infection selected shown Standard of care Support therapy Tocilizumab with COVID-19
[DOI] 10.3389/fphar.2022.825749 PMC 바로가기 [Article Type] Pharmacology

Vitamin D regulation of immune function during covid-19

Article

Published on 2022-01-292022-10-28
Journal: Reviews in Endocrine & Metabolic Disorders [Category] Coronavirus, COVID19(2023년), Fulltext, SARS,

[키워드] Activation adaptive Adaptive immunity airway epithelia alveolar Alveolar macrophages calcitriol Cathelicidin Cell chemokine clearance CYP27B1 cytokine Cytokine storm dead demonstrated dysregulation ENhance enzyme epithelia Express expresse help immune immune cells immune function infect Infection innate immune system Innate immunity investigated Ligand Local Lower respiratory tract lung macrophages mechanism metabolite modulating morbidity and mortality pandemic pathogen pathway pneumocyte producing Proinflammatory cytokine Proinflammatory response pulmonary Pulmonary alveolar macrophage reduce Regulation released respiratory pathogen rising SARS-CoV2 shown subsequent VDR viral infection viral neutralization virus Vitamin D Vitamin D receptor
[DOI] 10.1007/s11154-021-09707-4 PMC 바로가기 [Article Type] Article

Evidence of Microglial Immune Response Following Coronavirus PHEV Infection of CNS

Immunology

Published on 2022-01-102022-11-01
Journal: Frontiers in Immunology [Category] Coronavirus,

Clinical Management of COVID-19 in Cancer Patients with the STAT3 Inhibitor Silibinin

Perspective

Published on 2021-12-242022-10-28
Journal: Pharmaceuticals [Category] COVID-19,

[키워드] active cancer acute respiratory distress addition Admission ARDS arising C-reactive protein cascade caused clinical clinical trial Complete COVID-19 COVID-19 illness COVID-GRAM COVID-GRAM score Critical death demonstrated disease dysregulation EudraCT events exhibited high risk hospitalized patient IMPROVE inhibitor intensive care interstitial pneumonia Intervention invasive ventilation knowledge Legalon lymphocytopenia multiorgan failure outcome oxygen support Pathogenesis pathophysiology Patient patients Perspective predicted presenting Proinflammatory response pulmonary lesions receiving recruited required Research SARS-CoV-2 severe COVID-19 Side-effects silibinin STAT3 supportive care syndrome therapy transcriptional treating COVID-19 Treatment
[DOI] 10.3390/ph15010019 PMC 바로가기 [Article Type] Perspective

Carbon dioxide inhibits COVID-19-type proinflammatory responses through extracellular signal-regulated kinases 1 and 2, novel carbon dioxide sensors

이산화탄소는 세포 외 신호 조절 키나아제 1 및 2, 새로운 이산화탄소 센서를 통해 COVID-19 유형 전염증 반응을 억제합니다

Original Article

Published on 2021-11-062022-09-12
Journal: Cellular and Molecular Life Sciences [Category] MERS, SARS, 진단,

[키워드] activated acute respiratory syndrome Anti-inflammatory Bicarbonate Brain bronchial epithelial cells carbon dioxide cause caused cellular cellular pathways clinical study Concentration coronavirus COVID-19 cytokine developmental processes Dexamethasone Diseases drug Effect effective elevated Endothelial cell ERK1 ERK2 excessive inflammatory response Extracellular hydrogen peroxide IFNγ inactivated indicate Infection Inflammation inhibit inhibitor interleukin-6 kidneys kinase Lungs MAPK mitogen-activated protein kinase Modification oncogenesis pathway Prevent Proinflammatory cytokine Proinflammatory response RBD reactive oxygen specy Research S protein Safe SARS-CoV-2 severe coronavirus disease severe COVID-19 supplementary material the receptor-binding domain the spike protein TNFα Treatment tumour necrosis factor-α
[DOI] 10.1007/s00018-021-04005-3 PMC 바로가기 [Article Type] Original Article