Contribution of Trp63CreERT2-labeled cells to alveolar regeneration is independent of tuft cellsArticle Published on 2022-09-212022-11-15 Journal: eLife [Category] 바이오마커, 유전자 메커니즘, [키워드] alveolar alveolar epithelial cell alveolar epithelium alveolar regeneration Basal cell basal cells Biomarkers cause Cell Cell Biology Complete COVID-19 ectopic epithelial epithelial cell function IMPROVE increase independent Infection lineages lung lung parenchyma lung regeneration Lungs mechanism mice mouse mouse model Notch other organs proliferate promote promoted regenerative regenerative medicine regulate significantly stem cells suggested suppressed Tamoxifen tuft cell tuft cells viral infection Wnt [DOI] 10.7554/eLife.78217 PMC 바로가기
Specific Recognition of the 5′-Untranslated Region of West Nile Virus Genome by Human Innate Immune System인간의 타고난 면역 체계에 의한 웨스트 나일 바이러스 게놈의 5'-비번역 영역의 특이적 인식Article Published on 2022-06-132022-09-11 Journal: Viruses [Category] COVID19(2023년), SARS, 유전자 메커니즘, 치료제, [키워드] 5′-untranslated region all-atom molecular dynamics simulations Antiviral antivirals assist caused COVID-19 Dynamics emerging viruses Europe Genome highlighting Host immune response host protein Human immune immune system induce infection process Innate innate immune system Interaction knowledge mechanism molecular dynamics molecular mechanism molecular mechanisms neurological problems Nile oligoadenylate synthetase 1 outbreak Outbreaks pathogen proliferate Recognition recognition mechanism. Region repetition RNA RNA virus SARS-CoV-2 Specific spread to System therapeutic Trigger untranslated region Viral RNA virus West West Nile Virus [DOI] 10.3390/v14061282 PMC 바로가기 [Article Type] Article
Influencing Factors on College Students’ Willingness to Spread Internet Public Opinion: Analysis Based on COVID-19 Data in ChinaPublic Health Published on 2022-02-182022-10-31 Journal: Frontiers in Public Health [Category] COVID-19, COVID19(2023년), MERS, SARS, [키워드] adult attachment (AA) affecting affective applied China college conducted COVID-19 COVID-19 outbreak dissemination emotional emotional motivation (EM) ENhance Epidemic Epidemic prevention Factor influences on Internet key factor Perspective platform positive proliferate provided Public public health emergency public opinion questionnaire Questionnaires reliability Research Result Risk perception significantly SmaRT social motivation (SM) Spread student Validity [DOI] 10.3389/fpubh.2022.772833 PMC 바로가기 [Article Type] Public Health
Supplying the trip to antibody production—nutrients, signaling, and the programming of cellular metabolism in the mature B lineage항체 생산으로의 이동 - 영양소, 신호 전달, 성숙한 B 계통의 세포 대사 프로그래밍 제공Review Published on 2021-11-152022-09-11 Journal: Cellular and Molecular Immunology [Category] Fulltext, MERS, 유전자 메커니즘, 진단, [키워드] antibody B lymphocyte Cell cell surface receptor cell surface receptors cell type cell types cellular cellular metabolism COVID cytokine Cytokines elicit enzyme exhibiting Fatty acid focus gene transcription Germinal centres Glucose Glutamine Glycoproteins immune defense Infection Intermediary metabolism interstitium lead Lineage Lymphocytes mechanism metabolism microbe microbes microenvironment molecular nutrient pandemic Plasma cell Plasma cells plasmablast plasmablasts programming proliferate receive Recognition regulate secrete secreted secreting secretion Signal transduction Signaling Somatic hypermutation Stage sustained the cells Transcription translation turn Vaccine [DOI] 10.1038/s41423-021-00782-w PMC 바로가기 [Article Type] Review
Outbreaks of COVID-19 variants in US prisons: a mathematical modelling analysis of vaccination and reopening policies미국 교도소 내 COVID-19 변종 발병: 예방 접종 및 재개방 정책에 대한 수학적 모델링 분석Article Published on 2021-10-012022-09-11 Journal: The Lancet. Public Health [Category] SARS, 변종, [키워드] Abuse activities activity age Analysis balancing baseline benefit Cell center Characteristics Contact Control Coverage COVID-19 COVID-19 outbreak COVID-19 testing cumulative demographics dependent on disease control drug Drug Abuse evaluate expected family FIVE foundation Health Horowitz hospitalisation hospitalisations housing status Immunity Infection initial Intervention introduced maintain Mathematical modelling measure moderate NPI NPIs Open society outbreak Outbreaks outcome Participation populations prevention prison proliferate PROTECT provided reduce repeated resident risk scenario Science Society Sociodemographic trade-offs Transmission USA vaccination Vaccination Status Vaccine variant viral variant Viral variants widespread [DOI] 10.1016/S2468-2667(21)00162-6 PMC 바로가기 [Article Type] Article
Computer-aided prediction of inhibitors against STAT3 for managing COVID-19 associated cytokine stormCOVID-19 관련 사이토 카인 폭풍 관리를위한 STAT3에 대한 억제제의 컴퓨터 보조 예측Article Published on 2021-10-012022-08-31 Journal: Computers in biology and medicine [Category] 신약개발, [키워드] Accuracy Activation aromatic group aromatic groups AUC best build correlated COVID-19 COVID-19 pathogenesis COVID-19 patients cytokine Cytokine storm Cytokines Data analysis dataset develop drug FDA-Approved FDA-approved drug FDA-approved drugs identify inhibitor inhibitors lead machine learning classifier machine learning classifiers maximum outcome patients with COVID-19 Perindopril predict Predictive model predictive models proinflammatory cytokines Proinflammatory response proliferate second Severity of disease signaling pathway significantly STAT3 Tamoxifen the cytokine storm [DOI] 10.1016/j.compbiomed.2021.104780 PMC 바로가기 [Article Type] Article
Current therapeutic strategies for respiratory diseases using mesenchymal stem cellsReview Published on 2021-09-022022-10-30 Journal: MedComm [Category] COVID-19, [키워드] acute respiratory distress acute respiratory distress syndrome ARDS article Asthma Cell Characteristics chronic obstructive chronic obstructive pulmonary disease COPD current disadvantage dominant function functions Idiopathic pulmonary fibrosis immunoregulatory effects Inflammatory Inflammatory diseases IPF mechanism Mesenchymal stem cells MSC MSCs Perspective proliferate pulmonary disease pulmonary fibrosis Respiratory disease respiratory diseases stem cell syndrome therapeutic potential therapeutic strategy therapy undergo [DOI] 10.1002/mco2.74 PMC 바로가기 [Article Type] Review
Expression of SARS-CoV-2 Entry Factors in Human Alveolar Type II Cells in Aging and EmphysemaArticle Published on 2021-07-062022-10-28 Journal: Biomedicines [Category] COVID-19, [키워드] ACE2 aging alveolar type II cells ATII cause CD209L Cell described Diffuse alveolar damage disease emphysema expression facilitate Factor Host Human Infection lung transplant Lungs mRNA level Patient patients proliferate protein expression receptor Regulation RT-PCR SARS-CoV-2 SARS-CoV-2 entry factor SARS-COV-2 infection significantly increased smoker Smokers smoking Stress TMPRSS2 TMPRSS2 protease Type upregulation viral entry virus infection western blotting [DOI] 10.3390/biomedicines9070779 PMC 바로가기 [Article Type] Article
Intermittent Hypoxic Preconditioning: A Potential New Powerful Strategy for COVID-19 RehabilitationPharmacology Published on 2021-04-302022-10-31 Journal: Frontiers in Pharmacology [Category] COVID-19, [키워드] ACE2 receptor applied biochemical Cardiopulmonary cardiorespiratory cardiovascular systems cause chronic obstructive clinical clinical study COPD Coronary heart disease COVID-19 death diabetes dysfunction Dyspnea effective drug function heart failure HIF-1α host cells hypertension hypoxic immune function immune response IMPROVE Inflammation Inflammatory cytokine storm Intermittent intermittent hypoxic preconditioning Ischemia mechanism New organ other diseases oxidative stress pathophysiology Patient patients with COVID-19 physiological Pneumonia Potential Prognosis proliferate pulmonary disease rehabilitation Respiratory failure Respiratory system respiratory virus Safe severe cases Strategy the disease tissue Tolerance Treatment Vaccine virus [DOI] 10.3389/fphar.2021.643619 PMC 바로가기 [Article Type] Pharmacology
Analysis of the Long-Term Impact on Cellular Immunity in COVID-19-Recovered Individuals Reveals a Profound NKT Cell ImpairmentCOVID-19에서 회복된 개인의 세포 면역에 대한 장기적인 영향 분석은 심각한 NKT 세포 손상을 보여줍니다Research Article Published on 2021-04-272022-09-10 Journal: mBio [Category] MERS, SARS, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 affected analyzed caused CD4 CD4 and CD8 T cells CD8 T cell CD8 T cells Cell cell death cells cellular cellular immunity characterized Concomitant convalescence coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient COVID-19-convalescent individual COVID-19-convalescent individuals cytokine Cytokines decrease defined disease expression frequencies Frequency granzyme B GzmB immune signature immune system immunological change immunological changes Impact increase in increases in individual Interaction Ki67 Ki67 expression mononuclear cell mononuclear cells NKT NKT cell pandemic Patient Peripheral blood Peripheral blood mononuclear cells proliferate reduction in Regulatory Regulatory T cell respiratory SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome Coronavirus Significant significant decrease significantly sustained T cell T cell receptor T cells TCR the disease the patient while Wuhan [DOI] 10.1128/mBio.00085-21 PMC 바로가기 [Article Type] Research Article