An update on inhibitors targeting RNA-dependent RNA polymerase for COVID-19 treatment: Promises and challengesArticle Published on 2022-11-012022-11-15 Journal: Biochemical pharmacology [Category] COVID19(2023년), SARS, 변종, 치료제, [키워드] addition Antiviral antiviral drug causative pathogen complex Coronaviruses COVID-19 COVID-19 pandemic effective Effectiveness enzyme highest human cell identification Infection inhibitor inhibitors Interaction promise RdRP Replication Research RNA-dependent RNA polymerase SARS-CoV-2 Structural analysis therapeutic drug transmissible variant Viral RNA [DOI] 10.1016/j.bcp.2022.115279 PMC 바로가기
In silico drug repurposing against SARS-CoV-2 using an integrative transcriptomic profiling approach: Hydrocortisone and Benzhydrocodone as potential drug candidates against COVID-19통합 전사체 프로파일링 접근법을 사용하여 SARS-CoV-2에 대한 인실리코 약물 용도 변경: COVID-19에 대한 잠재적 약물 후보로서 히드로코르티손 및 벤즈히드로코돈Article Published on 2022-09-012022-09-11 Journal: Infection, genetics and evolution : journal of mol [Category] COVID19(2023년), SARS, 변종, 신약개발, 유전자 메커니즘, 치료제, [키워드] ADAR alveolar cell Analysis Anti-viral antiviral immune response Benzhydrocodone binding affinity CASP1 cellular response Cellular responses Clinical studies clinical study complementary COVID-19 COVID-19 pathogenesis determine drug drug candidate Drug repurposing dysregulated enrichment enrichment analysis evaluated FDA-approved drug FOS hallmark HBEGF Host Hydrocortisone ICAM1 identify IFI35 immune system in silico in silico approaches in viral in vitro in vivo experiment infected with SARS-CoV-2 Infectious disease involved IRF2 JUN management MMP9 molecular molecular docking Pathogenesis pathway Pathways promise Protein protein-protein interaction Proteins Repurposed drug Repurposed drugs SARS-CoV-2 SARS-COV-2 infection Signal transduction STAT3 subject suggested transcriptomic transcriptomic profile transcriptomics up-regulated USP18 viral infectious disease [DOI] 10.1016/j.meegid.2022.105318 PMC 바로가기 [Article Type] Article
Competing Responses to Global Inequalities in Access to COVID Vaccines: Vaccine Diplomacy and Vaccine Charity Versus Vaccine LibertyCOVID 백신에 대한 접근의 글로벌 불평등에 대한 경쟁적인 대응: 백신 외교 및 백신 자선 단체 대 백신 자유Review Published on 2022-08-152022-09-11 Journal: Clinical Infectious Diseases: An Official Publicat [Category] 변종, [키워드] access agency alternatives Antidote coronavirus vaccine Coronavirus vaccines country COVAX COVID Critical Donor dose doses Effectiveness Evolution Government Health immunize include inequality intellectual property International liberty organized overcome promise provide response seeking Social Justice structural violence Structure the vaccine transfer vaccination Vaccine vaccine apartheid vaccine charity vaccine diplomacy vaccine liberty. viral variant Viral variants [DOI] 10.1093/cid/ciac361 PMC 바로가기 [Article Type] Review
RT-qPCR and ATOPlex sequencing for the sensitive detection of SARS-CoV-2 RNA for wastewater surveillance폐수 감시를 위한 SARS-CoV-2 RNA의 민감한 검출을 위한 RT-qPCR 및 ATOPlex 시퀀싱Article Published on 2022-07-152022-09-11 Journal: Water research [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, 치료기술, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 appear approach assays assessment China CDC Combination Concentration Concentration method condition coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 deep sequencing detect detection Detection limit detection rate Detection sensitivity enveloped virus greater handling impacted less limit of detection MONITOR multiplex Mutation N1 and N2 nucleic acid nucleic acid extraction offer ORF1ab pandemic PCR platform powerful tool Probability promise quantitation quantitative PCR recovery required Result reverse transcription RT-qPCR RT-qPCR assay RT-qPCR assays SARS-CoV-2 SARS-CoV-2 RNA Sequencing severe acute respiratory syndrome Coronavirus shown Spread Surveillance US CDC variants variants of concern viral genome virus VoC wastewater [DOI] 10.1016/j.watres.2022.118621 PMC 바로가기 [Article Type] Article
Current Therapeutics for COVID-19, What We Know about the Molecular Mechanism and Efficacy of Treatments for This Novel VirusCOVID-19에 대한 현재 치료제, 이 새로운 바이러스에 대한 분자 메커니즘 및 치료 효능에 대해 우리가 알고 있는 것Review Published on 2022-07-122022-09-11 Journal: International Journal of Molecular Sciences [Category] COVID19(2023년), SARS, 치료제, [키워드] anti-viral agent anti-viral agents Antiviral approved caused clinical trial Combination coronavirus coronavirus disease coronavirus disease 19 COVID-19 COVID-19 disease COVID-19 pandemic COVID-19 therapeutics current Defense early treatment effective therapy Efficacy Epidemics Evolution globe Hospitalization immunomodulatory individual molecular mechanism molecular mechanisms monoclonal antibodies monoclonal antibody morbidity and mortality Multiple multitude novel novel SARS-CoV-2 virus pandemic performed Prevent promise Randomized controlled trial remained SARS-CoV-2 SARS-CoV-2 virus searched Severe acute respiratory syndrome severe disease shown Spread the SARS-CoV-2 virus the United State Therapeutic approach therapeutic option Therapeutics Therapies therapy Treatment Trial United States Vaccine were used [DOI] 10.3390/ijms23147702 PMC 바로가기 [Article Type] Review
Differential chromatin accessibility in peripheral blood mononuclear cells underlies COVID-19 disease severity prior to seroconversion말초 혈액 단핵 세포의 차별적인 염색질 접근성은 혈청 전환 이전의 COVID-19 질병 중증도의 기초가 됩니다Article Published on 2022-07-092022-09-11 Journal: Scientific Reports [Category] COVID19(2023년), MERS, SARS, 바이오마커, 유전자 메커니즘, 진단, 치료기술, 치료법, 치료제, [키워드] Accessibility anti-spike protein IgG Antiviral ATAC-seq CD14 CD14+ monocytes Cell cell differentiation cell type cell types changes in chromatin classical Course COVID-19 COVID-19 disease severity defined diagnostic disease disease course dysregulated early disease effective epigenome Evolution hosts IgG immune response immune responses individual Infection interleukin interleukin signaling IRF1 IRF7 less Mild mild SARS-CoV-2 infection Mild symptom moderate moderate disease moderate symptom Modification modifications Monocytes mononuclear cell mononuclear cells morphology motif observation occurred offer Outpatient outpatients Pathways PBMC PBMCs performed Peripheral blood Peripheral blood mononuclear cells profile promise Regulation remodeling responses RNA-Seq robust SARS-CoV-2 SARS-COV-2 infection Sequencing Seroconversion severity Signaling single-cell analyses single-cell analysis Stage Symptom symptom severity the disease transcription factor transposase Trigger triggers upregulation with COVID-19 [DOI] 10.1038/s41598-022-15668-8 PMC 바로가기 [Article Type] Article
Saquinavir: From HIV to COVID-19 and Cancer Treatment사퀴나비르: HIV에서 COVID-19 및 암 치료까지Review Published on 2022-07-052022-09-11 Journal: Biomolecules [Category] COVID19(2023년), SARS, 신약개발, 치료제, [키워드] 3CLpro anticancer antivirals Apoptosis approval approved drug Cancer Cancer cells cancer treatment Cell changed clinical trial clinical trials Combination COVID-19 COVID-19 outbreak cytotoxicity disease drug Drug repurposing Effect Follow-up help HIV impede in silico in vitro in vivo increased survival Invasion lack mind Neuroblastoma pathway pharmacological promise protease Protease inhibitor Research saquinavir saquinavir. SARS-CoV-2 main protease shown tested the SARS-CoV-2 therapy translated Treatment virus [DOI] 10.3390/biom12070944 PMC 바로가기 [Article Type] Review
Current vaccine strategies against SARS-CoV-2: Promises and challengesSARS-CoV-2에 대한 현재 백신 전략: 약속과 도전Review Published on 2022-07-012022-09-11 Journal: The Journal of Allergy and Clinical Immunology [Category] COVID19(2023년), MERS, SARS, 변종, 비임상, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addressed Approved vaccines coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 current develop Future globe identify Immunity Infectious disease Mutation overcome pandemic path preclinical vaccines produced promise PROTECT Research respiratory SARS-CoV-2 SARS-CoV-2 spike protein severe acute respiratory syndrome Coronavirus Side effects Spike protein Spread targets the SARS-CoV-2 upper respiratory tract Vaccine Vaccine hesitancy vaccine strategies variants variants of concern [DOI] 10.1016/j.jaci.2022.05.008 PMC 바로가기 [Article Type] Review
Development of Metal Complexes for Treatment of Coronaviruses코로나바이러스 치료를 위한 금속 착체 개발Article Published on 2022-06-082022-09-11 Journal: International Journal of Molecular Sciences [Category] COVID19(2023년), SARS, 변종, 치료제, [키워드] advent analyzed antibody antiviral therapies binding affinity Complete complex complexes contradiction coronavirus coronavirus disease coronavirus variants country COVID-19 Critical death described determine development disease docking effective Epidemic Infection lockdown mechanism metal metal complexes New coronavirus pandemic PDB pharmacokinetics pharmacophore pharmacophore. Prevent promise protease Protein Protein Data Bank RCSB pdb (Protein Data Bank) database related disease required Research SARS-CoV-2 Spread Structure structures suggested Toxicity transfer Treatment Vaccine variants virus [DOI] 10.3390/ijms23126418 PMC 바로가기 [Article Type] Article
Rapid Antigen Assays for SARS-CoV-2: Promise and PerilSARS-CoV-2에 대한 신속한 항원 분석: 약속과 위험Review Published on 2022-06-012022-09-11 Journal: Clinics in laboratory medicine [Category] COVID19(2023년), SARS, 치료기술, [키워드] Antigen Characteristics COVID-19 COVID-19 pandemic democratization Diagnosis diagnostic diagnostic testing facilitated Influenza promise Rapid rapid antigen test rapid antigen testing Rapid antigen tests respiratory viral infection respiratory viral infections SARS-CoV-2 SARS-CoV-2 detection scalability [DOI] 10.1016/j.cll.2022.03.001 PMC 바로가기 [Article Type] Review