prospective observational cohort – Communicable Diseases Research

The impact of an enhanced health surveillance system for COVID-19 management in Serrana, Brazil

Research article

Published on 2022-12-012022-10-05
Journal: Public Health in Practice [Category] 진단,

The association between adverse reactions and immune response against SARS-CoV-2 spike protein after vaccination with BNT162b2 among healthcare workers in a single healthcare system: a prospective observational cohort study

단일 의료 시스템에서 의료 종사자들 사이에서 BNT162b2 백신 접종 후 SARS-CoV-2 스파이크 단백질에 대한 부작용과 면역 반응 사이의 연관성: 전향적 관찰 코호트 연구

Observational Study

Published on 2022-11-302022-09-12
Journal: Human vaccines & immunotherapeutics [Category] MERS, SARS, 임상, 진단,

[키워드] administration Adverse Adverse reaction Anti-spike IgG antibody anti-spike IgG level Antibody titer association Asthma BNT162b2 BNT162b2 vaccine conducted COVID-19 Cutoff determine Factor first dose healthcare healthcare worker help humoral humoral immune response Humoral response IgG IgG level immune response information Local majority median median age mRNA mRNA vaccine of BNT162b2 participant Participants prospective observational cohort reaction recipients recruited reported SARS-CoV-2 anti-spike IgG SARS-CoV-2 spike protein second dose significantly higher systemic adverse reactions systemic reaction vaccination Vaccine was collected were measured with COVID-19 women
[DOI] 10.1080/21645515.2022.2048559 PMC 바로가기 [Article Type] Observational Study

Plasma SARS-CoV-2 nucleocapsid antigen levels are associated with progression to severe disease in hospitalized COVID-19

Article

Published on 2022-09-142022-11-15
Journal: Critical Care [Category] SARS, 치료기술,

[키워드] 95% CI adjusted Antigen association AUROC baseline Clinical deterioration Clinical outcome clinical outcomes clinical status Coagulation collected Concentration correlated correlation correlations Course COVID-19 Cutoff death detectable Enrollment Hospital admission hospitalized COVID-19 hospitalized patient host response ICU admission IL-10 IMPROVE In-hospital increase in Inflammation IP-10 marker mechanical ventilation Multiple multiple logistic regression N-antigen Negative predictive value Pathogenesis Patient plasma plasma biomarker plasma concentration plasma sample Positive predictive value Primary outcome Prognosis prognostic progression prospective observational cohort RAGE risk stratification SARS-CoV-2 SARS-CoV-2 N-antigen SARS-CoV-2 nucleocapsid secondary outcome severe disease significantly Study participants subject tested tissue damage unlikely upper respiratory tract Viral antigen Viral RNA was used were assessed were measured WHO WHO ordinal scale with COVID-19 World Health Organization
[DOI] 10.1186/s13054-022-04153-3 PMC 바로가기

Decreased Antibody Response After Severe Acute Respiratory Syndrome Coronavirus 2 Vaccination in Patients With Down Syndrome

Observational Study

Published on 2022-09-042022-10-05
Journal: The Journal of Infectious Diseases [Category] SARS, 임상, 진단,

A prospective observational study of post-COVID-19 chronic fatigue syndrome following the first pandemic wave in Germany and biomarkers associated with symptom severity

Observational Study

Published on 2022-08-302022-10-05
Journal: Nature Communications [Category] 바이오마커, 임상, 진단, 치료법,

SARS-CoV-2 infections in infants in Haiti 2020-2021; evidence from a seroepidemiological cohort

아이티 2020-2021년 유아의 SARS-CoV-2 감염; 혈청 역학 코호트의 증거

Observational Study

Published on 2022-08-252022-09-11
Journal: PLoS ONE [Category] SARS, 임상, 진단, 치료기술, 치료제,

[키워드] age antibody Blood children Cohort collected country Course covariate COVID-19 case DBS sample DBS samples detectable ELISA estimate Evidence Frequency Haiti hazard highest independent independent of Infant Infants Infection initial less longitudinal samples over pandemic Patient patient age pregnant women prospective observational cohort Receptor binding domain reported Retrospective analysis S1 protein sampling SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 S1 protein Seroconversion seroconversion rates serological response seropositive seropositive sample subsequent tested the SARS-CoV-2
[DOI] 10.1371/journal.pone.0273482 PMC 바로가기 [Article Type] Observational Study

Host Predictors of Broadly Cross-Reactive Antibodies Against Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Variants of Concern Differ Between Infection and Vaccination

중증 급성 호흡기 증후군 코로나바이러스 2(SARS-CoV-2)에 대한 광범위한 교차 반응성 항체의 숙주 예측 인자는 감염과 예방 접종 사이에 차이가 있습니다.

Observational Study

Published on 2022-08-242022-09-11
Journal: Clinical Infectious Diseases: An Official Publicat [Category] SARS, 변종, 임상, 진단,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Against antibody Antibody Response B.1.1.7 B.1.351 B.1.617.2 BMI booster Clinical characteristics clinician Clinicians Cohort collected concern contributed coronavirus coronavirus 2 cross-reactive cross-reactive antibodies cross-reactive antibody disease severity enzyme enzyme-linked immunosorbent enzyme-linked immunosorbent assay Factor Health healthy highest Host identify IgG IgG antibodies IgG antibody IgG level immunization Immunocompromised Immunoglobulin Immunoglobulin G individual Infection information metabolic health mounted mRNA vaccination P.1 participant plasma sample plasma samples Population populations predict prospective observational cohort Protective Protective antibody RBD Receptor binding domain Regression model regression models researchers respiratory responses SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 variant severe acute respiratory syndrome Coronavirus Spike receptor binding domain tested These data vaccination Vaccine Variability variants variants of concern Viral Viral variants virus variants Wuhan younger people
[DOI] 10.1093/cid/ciab996 PMC 바로가기 [Article Type] Observational Study

Robust T-Cell Responses in Anti-CD20-Treated Patients Following COVID-19 Vaccination: A Prospective Cohort Study

COVID-19 백신 접종 후 항-CD20 치료 환자의 강력한 T-세포 반응: 전향적 코호트 연구

Observational Study

Published on 2022-08-242022-09-11
Journal: Clinical Infectious Diseases: An Official Publicat [Category] SARS, 임상, 진단, 치료기술,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus anti-CD20 anti-CD20 therapy anti-CD20 treatment antibodies antibody Antibody Response Arthritis Breakthrough infection CD20 CD4 CD4 T cell CD8 T cell CD8 T cells cohort study Complication Control controls coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 vaccination COVID-19 vaccine detectable dose Effectiveness effector molecule effector molecules expressed Follow-up had no humoral humoral responses individual Mild mRNA COVID-19 vaccines mRNA-based COVID-19 vaccine multiple sclerosis Ocrelizumab Patient patients treated Prospective prospective observational cohort reduction respiratory response response rate response rates rheumatic disease Rheumatic diseases rheumatoid arthritis risk rituximab seroconverted severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 severe coronavirus disease severe COVID-19 significantly lower specific antibodies spike T cell T cells T-cell T-cell Response T-cell responses Th1 phenotype treated treated patient vaccination
[DOI] 10.1093/cid/ciab954 PMC 바로가기 [Article Type] Observational Study

COVID-19 infection among vaccinated and unvaccinated: Does it make any difference?

Observational Study

Published on 2022-07-152022-10-04
Journal: PLoS ONE [Category] 임상,

[키워드] Admission Care Characteristics Cohort comorbid conditions Complication Computed tomography conducted COVID-19 infection COVID-19 patient Critical Critical care D-dimer levels death demographics determine develop discharge effective ferritin hospitalized patients immunization individual Infection invasive ventilation lab LDH LOS median medical records mortality rate NIV non-invasive ventilation outcome Patient patients Preliminary data presenting Primary outcome Probability procalcitonin profiles proportion prospective observational cohort recruited reduction in required secondary outcome serum severity significantly higher significantly increased Support the patient university vaccinate vaccination with COVID-19
[DOI] 10.1371/journal.pone.0270485 PMC 바로가기 [Article Type] Observational Study

Use of Tumor Necrosis Factor-α Antagonists Is Associated With Attenuated IgG Antibody Response Against SARS-CoV-2 in Vaccinated Patients With Inflammatory Bowel Disease

종양 괴사 인자-α 길항제의 사용은 염증성 장 질환이 있는 백신 접종 환자에서 SARS-CoV-2에 대한 약화된 IgG 항체 반응과 관련이 있습니다

Observational Study

Published on 2022-07-052022-09-11
Journal: Frontiers in Immunology [Category] COVID19(2023년), MERS, SARS, 임상, 진단, 치료기술,

[키워드] Against age antagonist antagonists anti-SARS-CoV-2 antibody anti-SARS-CoV-2 vaccination antibody Antibody concentrations Antibody titer Antibody titers Biologicals Blood blood sampling bowel Characteristics clinical Clinical characteristics Combination completion Concentration COVID-19 Crohn's disease defined demonstrated detectable disease Effect elapsed geometric geometric mean IBD IgG IgG antibodies IgG antibody IgG antibody titer IgG antibody titers immune response immunoassay immunomodulating Immunosuppressive medication immunosuppressive medications increased risk independent independent of Inflammatory Inflammatory bowel disease medication Microparticle monotherapy Most patients mRNA mRNA vaccines mRNA-based vaccine mRNA-based vaccines Multivariable models Patient patient age patients patients treated prospective observational cohort quantitative determination RBD receive receiving Receptor-binding domain regimen response S1 subunit sampling SARS-CoV-2 SARS-COV-2 infection Seroconversion serological response significantly lower Spike protein the receptor-binding domain the S1 subunit the spike protein titer TNF-α-antagonists treated Treatment Tumor ulcerative colitis vaccination Vaccine vector was used were measured were recorded
[DOI] 10.3389/fimmu.2022.920333 PMC 바로가기 [Article Type] Observational Study