The classical and alternative circulating renin‐angiotensin system in normal dogs and dogs with stage B1 and B2 myxomatous mitral valve diseaseCardiology Published on 2023-03-232024-09-05 Journal: Journal of Veterinary Internal Medicine [Category] update2024, [키워드] angiotensin converting enzyme 2 equilibrium dialysis heart failure neurohormones protease inhibition urine aldosterone to creatinine ratio [DOI] 10.1111/jvim.16687 PMC 바로가기 [Article Type] Cardiology
Design and synthesis of novel phe-phe hydroxyethylene derivatives as potential coronavirus main protease inhibitorsArticle Published on 2022-10-012022-11-15 Journal: Journal of biomolecular structure & dynamics [Category] COVID19(2023년), SARS, 치료제, [키워드] Antiviral caused clinical trial Compound conducted coronavirus COVID-19 COVID-19 patients derivative docking score example Lopinavir molecular molecular docking molecular dynamic simulation molecular dynamics MPro pandemic protease inhibition Protease inhibitor SARS-CoV-2 stability synthesis [DOI] 10.1080/07391102.2021.1905549 PMC 바로가기
Mass Spectrometric Assays Reveal Discrepancies in Inhibition Profiles for the SARS-CoV-2 Papain-Like Protease질량 분석 분석은 SARS-CoV-2 파파인 유사 프로테아제에 대한 억제 프로필의 불일치를 보여줍니다Article Published on 2022-05-042022-09-11 Journal: ChemMedChem [Category] COVID19(2023년), SARS, 치료제, [키워드] applied assays auranofin clinical development cysteine functional highlighting in vitro inhibit inhibition inhibitor inhibitors M pro mass mass spectrometry mechanisms MONITOR MPro Nirmatrelvir non-structural proteins Nucleophilic cysteine protease Papain Papain-like protease PF-07321332 PF-07321332/nirmatrelvir PLPro profile protease protease inhibition Proteases reported SARS-CoV-2 SARS-CoV-2 main protease SARS-CoV-2 main protease/Mpro SARS-CoV-2 papain-like protease/PLpro selected selective targets the SARS-CoV-2 utility viral protease inhibition. viral replication [DOI] 10.1002/cmdc.202200016 PMC 바로가기 [Article Type] Article
Role of Iron Chelation and Protease Inhibition of Natural Products on COVID-19 InfectionReview Published on 2021-05-252022-10-30 Journal: Journal of Clinical Medicine [Category] COVID-19, [키워드] acting affecting Analysis caused chelation Combination component Course COVID-19 demonstrated develop docking effective highlighting inhibition Injury International iron iron chelation metabolism natural natural products Patient product promote protease protease inhibition Protease inhibitor protease inhibitors protocol pulmonary fibrosis recent respiratory diseases role SARS-CoV-2 SARS-COV-2 infection supportive therapies the epidemic therapeutic use viral infection virus infectivity [DOI] 10.3390/jcm10112306 PMC 바로가기 [Article Type] Review
Potential anti-COVID-19 agents, cepharanthine and nelfinavir, and their usage for combination treatmentArticle Published on 2021-03-262022-10-04 Journal: iScience [Category] 비임상, 치료제, [키워드] acute respiratory syndrome anti-inflammatory drug Anti-SARS-CoV-2 Activity Antiviral antiviral activity approved drug binding calculated Cell culture combination treatment combined treatment coronavirus coronavirus disease dose drug candidate drug concentration Efficacy Human immunodeficiency virus inhibit inhibited limit lung Medical Substance nelfinavir pharmaceutical Pharmaceutical Preparation Potential predict predicted proliferation protease inhibition Protease inhibitor Remdesivir required SARS-CoV-2 SARS-CoV-2 entry SARS-CoV-2 replication screened suppressed synergistic target cell target cells Treatment viral clearance viral replication Virology [DOI] 10.1016/j.isci.2021.102367 PMC 바로가기 [Article Type] Article
Evaluation of the Antiviral Activity of Sitagliptin-Glatiramer Acetate Nano-Conjugates against SARS-CoV-2 VirusArticle Published on 2021-02-242022-10-28 Journal: Pharmaceuticals [Category] COVID-19, [키워드] 1:1 3CL 3CL Protease Acetate activity acute respiratory syndrome addition Antiviral binding affinity carried cause cellular characterization China Clinical efficacy clinical study complex component Concentration coronavirus Coronavirus replication COVID COVID-19 COVID-19 pandemic criteria docking Efficacy epithelial cell evaluate factorial design Factors FDA-approved drugs Glatiramer acetate half-maximal inhibitory concentration Health IC50 investigated Nanoparticles outbreak Prevent protease protease inhibition required responses SARS-CoV-2 selected shown sitagliptin target cell TEM the SARS-CoV-2 virus transmission electron microscopy treat VERO-E6 virus were assessed [DOI] 10.3390/ph14030178 PMC 바로가기 [Article Type] Article
New Tetromycin Derivatives with Anti-Trypanosomal and Protease Inhibitory Activities †Article Published on 2011-09-262022-10-30 Journal: Marine Drugs [Category] Coronavirus, [키워드] activity Analysis anti-trypanosomal antiparasitic assigned Axinella cathepsin B cathepsin L Compound cysteine protease derivative derivatives Leishmania major marine sponge New NMR spectroscopy protease protease inhibition SARS-CoV M Streptomyce Streptomyces axinellae Structure tested tetromycin Trypanosoma [DOI] 10.3390/md9101682 PMC 바로가기 [Article Type] Article