Breaking the Chain: Protease Inhibitors as Game Changers in Respiratory Viruses ManagementReview Published on 2024-07-252024-09-05 Journal: International Journal of Molecular Sciences [Category] update2024, [키워드] Adenovirus Human rhinovirus inhibitors Proteases respiratory viruses SARS-CoV-2 [DOI] 10.3390/ijms25158105 PMC 바로가기 [Article Type] Review
Mutational profiling of SARS-CoV-2 papain-like protease reveals requirements for function, structure, and drug escapeArticle Published on 2024-07-232024-09-05 Journal: Nature Communications [Category] update2024, [키워드] Proteases Viral proteins X-ray crystallography [DOI] 10.1038/s41467-024-50566-9 PMC 바로가기 [Article Type] Article
Aprotinin (I): Understanding the Role of Host Proteases in COVID-19 and the Importance of Pharmacologically Regulating Their FunctionReview Published on 2024-07-102024-09-05 Journal: International Journal of Molecular Sciences [Category] update2024, [키워드] angiotensin-converting enzyme type 2 (ACE2) Aprotinin COVID-19 kinin–kallikrein system (KKS) Proteases Renin–angiotensin–aldosterone system (RAAS) thrombosis [DOI] 10.3390/ijms25147553 PMC 바로가기 [Article Type] Review
Plasmodium falciparum proteases as new drug targets with special focus on metalloproteasesarticle Published on 2024-06-302024-09-01 Journal: Molecular and Biochemical Parasitology [Category] 말라리아, [키워드] drug resistance inhibitors malaria metalloproteases Plasmodium falciparum Proteases [Article Type] article
Aprotinin (II): Inhalational Administration for the Treatment of COVID-19 and Other Viral ConditionsReview Published on 2024-06-292024-09-05 Journal: International Journal of Molecular Sciences [Category] update2024, [키워드] angiotensin-converting enzyme type 2 (ACE2) Antifibrinolytic Aprotinin COVID-19 inhalational administration kinin–kallikrein system (KKS) Pharmacodynamic pharmacokinetic Proteases Renin–angiotensin–aldosterone system (RAAS) [DOI] 10.3390/ijms25137209 PMC 바로가기 [Article Type] Review
Host Cell Proteases Involved in Human Respiratory Viral Infections and Their Inhibitors: A ReviewReview Published on 2024-06-192024-09-05 Journal: Viruses [Category] update2024, [키워드] protease inhibitors Proteases respiratory proteases SARS-CoV-2 viruses [DOI] 10.3390/v16060984 PMC 바로가기 [Article Type] Review
Preclinical evaluation of the SARS-CoV-2 M pro inhibitor RAY1216 shows improved pharmacokinetics compared with nirmatrelvirArticle Published on 2024-03-292024-09-05 Journal: Nature Microbiology [Category] update2024, [키워드] Enzyme mechanisms Proteases X-ray crystallography [DOI] 10.1038/s41564-024-01618-9 PMC 바로가기 [Article Type] Article
Identification of receptors and factors associated with human coronaviruses in the oral cavity using single-cell RNA sequencingResearch Article Published on 2024-03-162024-09-05 Journal: Heliyon [Category] update2024, [키워드] human coronaviruses oral cavity Proteases Restriction factors SARS-CoV-2 scRNA-seq viral receptors [DOI] 10.1016/j.heliyon.2024.e28280 PMC 바로가기 [Article Type] Research Article
Neutrophil proteases are protective against SARS-CoV-2 by degrading the spike protein and dampening virus-mediated inflammationResearch Article Published on 2024-03-122024-09-05 Journal: JCI Insight [Category] update2024, [키워드] COVID-19 Inflammation Neutrophils Proteases serpins [DOI] 10.1172/jci.insight.174133 PMC 바로가기 [Article Type] Research Article
Targeting and monitoring ovarian cancer invasion with an RNAi and peptide delivery systemNanoparticles for RNA Therapeutics Published on 2024-03-042024-09-05 Journal: Proceedings of the National Academy of Sciences of [Category] update2024, [키워드] Layer-by-layer assembly Proteases RNAi delivery synthetic biomarker theranostics [DOI] 10.1073/pnas.2307802121 PMC 바로가기 [Article Type] Nanoparticles for RNA Therapeutics