CRL4B E3 ligase recruited by PRPF19 inhibits SARS-CoV-2 infection by targeting ORF6 for ubiquitin-dependent degradationResearch Article Published on 2024-02-242024-09-05 Journal: mBio [Category] update2024, [키워드] CRL4B E3 ligase ORF6 proteasomal degradation PRPF19 SARS-CoV-2 [DOI] 10.1128/mbio.03071-23 PMC 바로가기 [Article Type] Research Article
Targeting proteostasis of the HEV replicase to combat infection in preclinical modelsArticle Published on 2023-04-012023-06-11 Journal: Journal of hepatology [Category] E형 간염, [키워드] antiviral drugs Hepatitis Hepatitis E virus (HEV) Hsp90 ORF1 preclinical study proteasomal degradation Proteostasis Rodent model viral replication [DOI] 10.1016/j.jhep.2022.12.010
Structural similarity-based prediction of host factors associated with SARS-CoV-2 infection and pathogenesisSARS-CoV-2 감염 및 발병과 관련된 숙주 인자의 구조적 유사성 기반 예측Article Published on 2022-08-012022-09-11 Journal: Journal of biomolecular structure & dynamics [Category] SARS, 유전자 메커니즘, [키워드] Analysis Apoptosis axon guidance CASP3 CD4 CD4 degradation clathrin Clathrin-mediated endocytosis clathrin-mediated endocytosis. composed Degradation down-regulate eIF2a Endoplasmic reticulum endosome enriched pathway enrichment analysis ERGIC event Factor Factors Genome heme HOPS complex Host information inhibitor interferon IRF1 life cycle matrix protein mechanism medical intervention membrane occur organized pandemic Pathogenesis phosphorylate predicted proteasomal degradation Protein protein kinase protein-protein interaction public health replicate reveal RNA synthesis SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 life cycle Signaling similarity T cell therapeutic intervention TP53 translational Transport UBA52 UBC Vesicle viral entry viral pathogenesis Viral protein virion assembly Virus life cycle [DOI] 10.1080/07391102.2021.1874532 PMC 바로가기 [Article Type] Article
Differential Ubiquitination as an Effective Strategy Employed by the Blood-Brain Barrier for Prevention of Bacterial Transcytosis혈액-뇌 장벽이 세균의 세포간 이동을 예방하기 위해 사용하는 효과적인 전략으로서의 차별적 유비퀴틴화Article Published on 2022-01-182024-08-24 Journal: Retinal cases & brief reports [Category] 폐렴구균 감염증, [키워드] autophagy blood-brain barrier K48-ubiquitination K63-ubiquitination proteasomal degradation proteasome Streptococcus pneumoniae ubiquitin topology ubiquitination
SARS-CoV-2 Spike Antagonizes Innate Antiviral Immunity by Targeting Interferon Regulatory Factor 3SARS-CoV-2 스파이크는 인터페론 조절 인자 3을 표적으로 하여 선천적인 항바이러스 면역을 길항합니다Cellular and Infection Microbiology Published on 2022-01-102022-09-11 Journal: Frontiers in Cellular and Infection Microbiology [Category] 유전자 메커니즘, [키워드] Activation acute respiratory syndrome Analysis antiviral immune response biochemical blocked Cell cells Co-expression analysis control cells Corona virus COVID-19 COVID-19 pathogenesis cytokine Cytokines disease disease severity downstream ectopic expression evade experiment expressing expression expression of SARS-CoV-2 facilitate Factor Genes Host IFN-I IFNβ immunoassay immunoassays indicated infections inhibitor Innate innate immune response Innate immunity interferon interferon regulatory factor IRF3 mechanism NF-κB Pathogenesis Pattern recognition pattern recognition receptor proteasomal degradation Protein remained respiratory RIG-I RIG-I antiviral RNA SARS-CoV-2 SARS-CoV-2 spike Severe Acute Respiratory Syndrome Corona Virus Signaling spike Stat1 stimulated suppressed targeting the SARS-CoV-2 transcription factor type I interferon Viral viral burden Viral RNA virus Virus Disease virus infections [DOI] 10.3389/fcimb.2021.789462 PMC 바로가기 [Article Type] Cellular and Infection Microbiology
Exploring COVID-19 pathogenesis on command-line: A bioinformatics pipeline for handling and integrating omics data명령줄에서 COVID-19 발병 기전 탐색: omics 데이터를 처리하고 통합하기 위한 생물정보학 파이프라인Article Published on 2022-01-012022-09-11 Journal: Advances in protein chemistry and structural biolo [Category] SARS, 유전자 메커니즘, [키워드] Activation acute respiratory syndrome acute respiratory syndrome coronavirus Bioconductor bioinformatics cholesterol cholesterol metabolism cohort of patients comprehensive view coronavirus COVID-19 COVID-19 pathogenesis Data integration Differentially expressed genes ECM experiment global public health handling healthy highly pathogenic immune system activity infected individuals infected patients information knowledge leukocyte lung mapped marker mechanism metabolism molecules offer Open Access pathway Pathways plasma proteasomal degradation Protein Proteins proteome proteomics Quantitative raw data regulated robust robustness SARS-CoV-2 severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 transcript Transcriptome transcriptomics transcriptomics data transcripts virus Wuhan Wuhan, China [DOI] 10.1016/bs.apcsb.2022.04.002 PMC 바로가기 [Article Type] Article
Long-chain polyphosphates impair SARS-CoV-2 infection and replicationResearch Article Published on 2021-07-062022-10-04 Journal: Science Signaling [Category] SARS, 변종, 치료제, [키워드] ACE2 acute respiratory syndrome addition amino acid residue analyses Analysis angiotensin-converting enzyme 2 antiviral activities antiviral activity B.1.1.7 SARS-CoV-2 variant binding Blood Caco2 cell Cell composed conserved coronavirus delivery docking Effect ELISA facilitate functional genomic HIV-1 infection host receptor impair impairing in viral in vitro incubated Infection Inflammatory response inhibit SARS-CoV-2 inorganic Interaction investigated involved linear polymer mapped molecular docking Nasal Epithelial cells nebulized phosphate polymerase polyphosphate positive-sense presenting proinflammatory cytokines proteasomal degradation Protein RdRP reduced repeated Replication required resulting RNA transcript RNA-dependent RNA polymerase SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 RdRp SARS-CoV-2 replication site-directed mutagenesis structural proteins subgenomic RNAs tested therapeutic use Toxicity Vero E6 viral entry Viral RNA virus virus entry [DOI] 10.1126/scisignal.abe5040 PMC 바로가기 [Article Type] Research Article
ORF10–Cullin-2–ZYG11B complex is not required for SARS-CoV-2 infection423 Published on 2021-04-272022-10-29 Journal: Proceedings of the National Academy of Sciences of [Category] COVID-19, MERS, SARS, [키워드] acute respiratory syndrome Antiviral bind cellular complex coronavirus Critical CUL2 cultured cells Degradation E3 ubiquitin ligase Evidence example function gene product imperative in vitro Infection inhibit inhibitor Interaction investigated N terminus ORF10 Pathogenesis promote proteasomal degradation Protein protein-coding gene regulate regulated required SARS-CoV-2 SARS-COV-2 infection Significance subsequent the SARS-CoV-2 genome Transmission understanding unique viral genome virulence while ZER1 ZYG11B [DOI] 10.1073/pnas.2023157118 PMC 바로가기 [Article Type] 423
Targeted intracellular degradation of SARS-CoV-2 via computationally optimized peptide fusionsArticle Published on 2020-11-232022-10-04 Journal: Communications Biology [Category] SARS, 치료제, [키워드] Antiviral Antiviral strategies approved catastrophic caused COVID-19 pandemic Critical Degradation E3 ubiquitin ligase effective elicited fusion Health human cell human cells inhibit inhibiting novel coronavirus SARS-CoV-2 peptide platform proportions proteasomal degradation Protein design RBD Receptor binding domain Recombinant peptide therapy recruit robust SARS-CoV-2 Spike protein subsequent the SARS-CoV-2 therapeutic unique Vaccine variant viral spike protein virus [DOI] 10.1038/s42003-020-01470-7 PMC 바로가기 [Article Type] Article
Partial impairment of late-stage autophagic flux in murine splenocytes leads to sqstm1/p62 mediated nrf2-keap1 antioxidant pathway activation and induced proteasome-mediated degradation in malariaarticle Published on 2020-10-312024-09-01 Journal: Microbial Pathogenesis [Category] 말라리아, [키워드] Macroautophagy in splenocytes nrf2-keap1 pathway Plasmodium mediated autophagic regulation of splenocytes proteasomal degradation sqstm1/p62 role in malaria ubiquitination [Article Type] article