Coagulation Parameters in Post-Covid-19 Condition in Relation to Various Titers of Anti-SARS-CoV-2 IgG in Blood PlasmaOriginal Research Published on 2023-12-272024-09-05 Journal: International Journal of General Medicine [Category] update2024, [키워드] antithrombin III long-COVID protein C thrombomodulin [DOI] 10.2147/IJGM.S425496 PMC 바로가기 [Article Type] Original Research
Decreased protein C activity, lower ADAMTS13 antigen and free protein S levels accompanied by unchanged thrombin generation potential in hospitalized COVID-19 patientsFull Length Article Published on 2023-01-242024-09-05 Journal: Thrombosis research [Category] update2024, [키워드] ADAMTS13 COVID-19 Free protein S protein C Thrombin generation [DOI] 10.1016/j.thromres.2023.01.016 PMC 바로가기 [Article Type] Full Length Article
Multi-Design Differential Expression Profiling of COVID-19 Lung Autopsy Specimens Reveals Significantly Deregulated Inflammatory Pathways and SFTPC Impaired TranscriptionCOVID-19 폐 부검 표본의 다중 디자인 차등 발현 프로파일링은 상당히 규제 완화된 염증 경로 및 SFTPC 손상된 전사를 나타냅니다Article Published on 2022-03-162022-09-11 Journal: Cells [Category] SARS, 유전자 메커니즘, [키워드] Activation Autopsy carried cathepsin Cathepsin C CD163 CFB Clinical diagnosis complement Complement activation controls COVID-19 COVID-19 patient COVID-19-related death CTSC deaths deregulation develop differential expression effective effective therapy FFPE formalin formalin-fixed paraffin-embedded Gene expression profiling had no high viral load IFIT1 immune signature immunohistochemistry Impaired Inflammation ISG15 lung lung damage Macrophage macrophage polarization mechanism MS4A4A Nasopharyngeal swab OAS1 overexpression paraffin pathway pharmacological strategies PKM positive potential therapeutic targets Prevent probe Profiling Protein protein C pulmonary viral quantified required Respiratory disease RNA RNA-Seq RSAD2 SARS-CoV-2 SARS-COV-2 infection selected Seven SFTPC Siglec-1 SIGLEC1 signaling pathway specimen tissue sample tissue samples transcriptomic Transcriptomic profiling type I interferon Viral load were used [DOI] 10.3390/cells11061011 PMC 바로가기 [Article Type] Article
Comment on ‘SARS-CoV-2 suppresses anticoagulant and fibrinolytic gene expression in the lung’'SARS-CoV-2는 폐에서 항응고제 및 섬유소 용해 유전자 발현을 억제한다'에 대한 논평Comment Published on 2022-01-112022-09-10 Journal: eLife [Category] SARS, 유전자 메커니즘, [키워드] Analysis analyzed Anticoagulant asthmatic BALF Bronchoalveolar lavage fluid Coagulation coagulation cascade Coagulopathies Comment comparable Complete COVID-19 COVID-19 patient COVID-19 patients data set data sets dataset datasets expression extrinsic Factor FIBRIN fibrinogen fibrinolysis fibrinolytic Gene Expression Human increases in Inflammatory inhibitor Interaction Local Lungs master regulator mechanism Microbiome mRNA expression obese performed protein C reduced remained reported Retrospective analysis RNA-Seq RNA-sequencing SARS-CoV-2 significantly supported suppresse TFPI These data Tissue Factor Transcriptome transcriptomic analysis upregulation [DOI] 10.7554/eLife.74268 PMC 바로가기 [Article Type] Comment
Investigation of the Molecular Mechanism of Coagulopathy in Severe and Critical Patients With COVID-19COVID-19 중증 및 중환자에서 응고병증의 분자 기전 조사Immunology Published on 2021-12-162022-09-11 Journal: Frontiers in Immunology [Category] SARS, 유전자 메커니즘, 진단, [키워드] Anticoagulant antithrombin III (ATIII) association change Coagulation factors coagulation test coagulation tests Coagulopathy collected Control coronavirus disease Coronavirus disease 2019 COVID-19 Critical D-dimer D-dimer (DD) Degradation Disruption FDPs FIBRIN fibrin degradation products fibrinogen following test group healthy controls homeostasis individual investigated investigation involved Lupus lupus anticoagulant molecular mechanism nine p -values partial thromboplastin time pathology Patient patients performed plasma PROC Prognosis prognosis of patients pros Protein protein C protein C (PC) protein S Prothrombin time Regulatory reported severe patients significant difference THROMBOPLASTIN [DOI] 10.3389/fimmu.2021.762782 PMC 바로가기 [Article Type] Immunology
Relationship between serum soluble endothelial protein C receptor level and COVID-19 findings혈청 용해성 내피 단백질 C 수용체 수치와 코로나19 소견과의 관계Article Published on 2021-12-012022-09-11 Journal: Blood coagulation & fibrinolysis : an internationa [Category] SARS, 바이오마커, 치료기술, [키워드] activated Admission anti-inflammatory activity Anticoagulant association biochemical blood specimen blood specimens Chain Reaction clinically Coagulation coagulation cascade Coagulopathy collected Complication Computed tomography Course COVID-19 COVID-19 patient detect diagnosed e parameters endothelial enrolled EPCR GGO ground-glass opacity group Inflammation inflammatory process laboratory parameter Laboratory parameters laboratory-confirmed leads member negative patients no difference onset of symptom parameter Patient PCR positive Protein protein C qPCR test receptor reduce related disease relationship reported reverse transcription RT-qPCR RT-qPCR test serum shown significantly higher Symptoms Thorax thrombosis was performed [DOI] 10.1097/MBC.0000000000001070 PMC 바로가기 [Article Type] Article
Could Soluble Endothelial Protein C Receptor Levels Recognize SARS-CoV2-Positive Patients Requiring Hospitalization?가용성 내피 단백질 C 수용체 수준이 입원이 필요한 SARS-CoV2-양성 환자를 인식할 수 있습니까?Observational Study Published on 2021-11-012022-09-11 Journal: Shock (Augusta, Ga.) [Category] MERS, SARS, 바이오마커, 임상, [키워드] 95% CI activated activities activity Admission age an area Analysis Anti-inflammatory Anticoagulant APC BMI characteristic clinical impact Cohort contribute COVID-19 COVID-19 patient COVID-19 patients D-dimers elevated endothelial EPCR Factor Hospital admission Hospitalization hospitalized patient hospitalized patients identify inhibit investigated lead Level multiple logistic regression Multiple logistic regression analysis Outpatient outpatients Pathways Patient patients phenotype plasma point-of-care potential risk Predictive Predictive value prognostic Protein protein C receiver receiver operating characteristic receptor regulate reported ROC ROC Curve Symptoms was performed were measured [DOI] 10.1097/SHK.0000000000001780 PMC 바로가기 [Article Type] Observational Study
Pathogenic lipid-binding antiphospholipid antibodies are associated with severity of COVID-19병원성 지질 결합 항인지질 항체는 COVID-19의 중증도와 관련이 있습니다Article Published on 2021-09-012022-09-11 Journal: Journal of thrombosis and haemostasis : JTH [Category] SARS, 진단, 치료기술, 치료제, [키워드] accelerate analyzed antibody antiphospholipid antibodies antiphospholipid antibody association Blood Blood coagulation blood coagulation disorder C-reactive protein catastrophic Cell Clinical course Clinical severity Coagulation coagulation disorder Coagulopathy Cohort complex Concentration coronavirus coronavirus disease coronavirus disease 19 COVID-19 COVID-19 patient COVID-19 patients Critical D-dimer dependent on described detectable dimer disease severity endothelial endothelial cells endothelial protein C receptor EPCR expand hallmark Hospitalized hospitalized COVID-19 patients IgG induce Infection Inflammation inflammatory effects Inflammatory response Lipid manifestation marker median Microvascular thrombosis monocyte Monocytes Mortality outcome pathogenic Patient poor prognosis producing Protein protein C prothrombotic prothrombotic syndrome receptor respiratory secreting Severe acute respiratory syndrome severity of COVID-19 signaling pathway single center stroke syndrome thrombosis thrombotic Thrombus thrombus formation venous [DOI] 10.1111/jth.15455 PMC 바로가기 [Article Type] Article
A Prospective Study of Specialized Coagulation Parameters in Admitted COVID-19 Patients and Their Correlation With Acute Respiratory Distress Syndrome and OutcomePathology Published on 2021-08-262022-10-31 Journal: Cureus [Category] COVID-19, [키워드] abnormality absence activated addressed Admission Affect age antagonist Anticoagulant Anticoagulants Antithrombin aPTT ARDS ARDS patient association AUC automated benefit category Chrom chronic obstructive Coagulation coagulation abnormalities coagulation parameter coagulation test Coagulopathy Comorbidity complication of COVID-19 Contact COPD COVID patient COVID-19 COVID-19 case COVID-19 patient criteria cut-off Cytokine storm D-dimer D-dimer level dead Diabetes Mellitus diagnosis of COVID-19 dimer discharge distress elevated ELISA females fibrinogen fibrinolytic France Free history hospital hypertension ICU identify in-patient incidence INR International liquid male median age Mortality non-survivor normalized objective outcome outcomes Patient patients performed plasma predict Pregnancy presenting prognostic biomarker Prospective Prospective Study Protein protein C Prothrombin time protocol pulmonary disease recruited respiratory Result routine significantly significantly higher SOFA score STAR study inclusion Symptom syndrome therapy tissue plasminogen activator [DOI] 10.7759/cureus.17463 PMC 바로가기 [Article Type] Pathology
Supplementary research on K150del variant of activated protein C활성화된 단백질 C의 K150del 변이체에 대한 추가 연구Research Paper Published on 2021-05-152022-09-10 Journal: Aging (Albany NY) [Category] MERS, SARS, 변종, [키워드] 2019 coronavirus disease activated activated protein C activities administration alteration anti-apoptotic Anti-inflammatory Anti-inflammatory effects Anticoagulant APC apoptotic auxiliary Cell clinician Concentration coronavirus coronavirus disease COVID-19 cytoprotective activity differentially expressed gene Differentially expressed genes disease risk Effects functional HEK 293T help in viral infections Inflammatory lung tissue mutant performed predict Protein protein C reduced repeated Research restored signaling pathways therapeutic Transcriptome transcriptome analysis treated variant Viral viral infections virus virus defense [DOI] 10.18632/aging.202904 PMC 바로가기 [Article Type] Research Paper