Role and mechanistic actions of protein kinase inhibitors as an effective drug target for cancer and COVIDMini Review Published on 2023-05-172024-09-05 Journal: Archives of Microbiology [Category] update2024, [키워드] Cancer Chronic inflammatory response COVID Cytokines protein kinases [DOI] 10.1007/s00203-023-03559-z PMC 바로가기 [Article Type] Mini Review
SARS-CoV-2 replication in airway epithelia requires motile cilia and microvillar reprogrammingArticle Published on 2023-01-052023-07-11 Journal: Cell [Category] COVID19(2023년), [키워드] airway epithelial cells cilia COVID-19 microvilli organoids protein kinases proteomics respiratory synctital virus respiratory virus SARS-CoV-2 [DOI] 10.1016/j.cell.2022.11.030 PMC 바로가기
When cyclin-dependent kinases meet viral infections, including SARS-CoV-2사이클린 의존성 키나제가 SARS-CoV-2를 포함한 바이러스 감염을 만날 때Review Published on 2022-07-012022-09-11 Journal: Journal of medical virology [Category] COVID19(2023년), SARS, 치료제, [키워드] Antiviral CDKs Cell cell division Critical Defense demonstrated DNA DNA viruses drug target function highlight Host in viral Infection kinase kinases molecular protein kinase protein kinases recent Regulation RNA RNA viruses SARS-CoV-2 Therapeutic strategies therapeutic strategy transcriptional regulation viral infection viral infections [DOI] 10.1002/jmv.27719 PMC 바로가기 [Article Type] Review
Association of Complement and MAPK Activation With SARS-CoV-2–Associated Myocardial InflammationSARS-CoV-2–관련 심근 염증과 보체 및 MAPK 활성화의 연관성Research Published on 2021-12-152022-09-10 Journal: JAMA Cardiology [Category] MERS, SARS, 유전자 메커니즘, [키워드] abundance age Analysis assessment biopsies C1q capture capture sequencing cardiac Cardiomyopathy cascade case sery CD163 center Characteristics characterized clade Cohort cohort of patients collected complement Complement cascade component confirmation cysteine Endomyocardial biopsy Ethnicity Exome exploratory exposure Factor finding Future Germany highest histologic Hospitalized immune pathway immune signature Immune-mediated implication Importance individual Infection Inflammatory inflammatory condition inflammatory conditions inhibitor Injury kinases lymphocyte Lymphocyte count lymphocyte counts Macrophage macrophages male MAPK mass mass spectrometry Maximilian measure median age mitogen mitogen-activated protein kinase Munich Myocardial inflammation myocardial injury myocarditis objective participant Participants pathway Pathways Patient patients with SARS-CoV-2 phenotype Point Protein protein kinase protein kinases proteinase Proteins proteomic Proteomic analysis reduce Referral Relevance Result RNA SARS-COV-2 infection Sequencing Serine setting signaling cascade similarities specimen specimens subunit the median threonine tissue transcript transcriptomic transcriptomic analysis Treatment strategies treatment strategy Tübingen university upregulated upregulation Viral viral myocarditis were measured [DOI] 10.1001/jamacardio.2021.5133 PMC 바로가기 [Article Type] Research
Machine learning identifies molecular regulators and therapeutics for targeting SARS‐CoV2‐induced cytokine releaseArticle Published on 2021-09-062022-10-31 Journal: Molecular Systems Biology [Category] COVID-19, SARS, [키워드] Baricitinib cellular Chemical biology Combination COVID‐19 COVID‐19 patient cytokine cytokine production cytokine release Dexamethasone domain downstream drugs EPHA7 identify immunology induce Inflammatory inhibit inhibiting inhibitor IRAK1 JAK1 kinase kinases Lung inflammation machine machine learning MAP3K8 MAPK12 massive Microbiology, Virology & Host Pathogen Interaction moderate molecular myeloid cell N‐terminal domain NTD outcomes outperform PBMCs phenotypic phenotypic screening Ponatinib protein kinases required SARS‐CoV‐2 SARS‐CoV‐2 infection SARS‐CoV‐2 signaling pathway Spike protein therapeutic option Treatment Trigger variants [DOI] 10.15252/msb.202110426 PMC 바로가기 [Article Type] Article
Revisiting Drug Development Against the Neglected Tropical Disease, Amebiasis소외된 열대 질병인 아메바증에 대한 약물 개발 재조명Article Published on 2021-02-242024-07-30 Journal: Frontiers in Cellular and Infection Microbiology [Category] 세균성이질, [키워드] Amebiasis drug repurposing and discovery drug targets metabolic enzymes metabolic kinases Proteases protein kinases protozoan parasite [DOI] 10.3389/fcimb.2020.628257 PMC 바로가기
Identification and functional analysis of the SARS-COV-2 nucleocapsid proteinSARS-COV-2 뉴클레오캡시드 단백질의 동정 및 기능분석Research Article Published on 2021-02-222022-09-10 Journal: BMC Microbiology [Category] MERS, 치료법, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Affect Analysis analyzed applied biological function coil composed conducted coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 depth analysis Drug discovery flow cytometry functional Health Organization hydrophobic identification identify increased expression kinases mass spectrometry MERS-CoV N protein nuclear protein nucleocapsid nucleocapsid protein Nucleocapsid protein (N protein) phosphorylated Phosphorylation phosphorylation site phosphorylation sites physicochemical Physicochemical properties Pneumonia predicted prediction Protein protein kinase protein kinases ProtParam tool PROVEAN random reliability respiratory Result SARS-CoV SARS-CoV-2 SARS-CoV-2 nucleocapsid server severe acute respiratory syndrome Coronavirus significantly similarity SOPMA tool Structure subcellular localization supplementary material target targets tertiary structure therapeutic targets transfected with TUBA1C TUBB6 Vaccine virus widespread World Health Organization [DOI] 10.1186/s12866-021-02107-3 PMC 바로가기 [Article Type] Research Article
The role of SARS‐CoV‐2 target ACE2 in cardiovascular diseasesReview Published on 2021-01-142022-10-29 Journal: Journal of Cellular and Molecular Medicine [Category] COVID-19, MERS, [키워드] ACE2 ACE2 expression antioxidant approach attack binding calcium ion cardiovascular disease cardiovascular diseases cardiovascular system Cell cells coronavirus disease COVID‐19 CVD Effect enzyme fibrosis functional growth factor identify mechanism multiple organ myocardial injury pandemic Pathways protein kinases RAS receptor responsible SARS‐CoV‐2 SARS‐CoV‐2 shown suggested target Therapies virus [DOI] 10.1111/jcmm.16239 PMC 바로가기 [Article Type] Review
Mutations in the phosphorylation sites of SARS-CoV-2 encoded nucleocapsid protein and structure model of sequestration by protein 14-3-3Article Published on 2020-10-292023-07-07 Journal: Biochemical and Biophysical Research Communication [Category] SARS, [키워드] C-TAK1 nucleocapsid protein Phosphorylation dependent binding and sequestration Protein 14-3-3 protein kinases SARS-CoV-2 [DOI] 10.1016/j.bbrc.2020.08.024 PMC 바로가기
The sequence at Spike S1/S2 site enables cleavage by furin and phospho-regulation in SARS-CoV2 but not in SARS-CoV1 or MERS-CoVArticle Published on 2020-10-092022-10-29 Journal: Scientific Reports [Category] COVID-19, SARS, [키워드] arginine basophilic Biochemistry caused clade cleavage cleave coronavirus enzyme furin in vitro in vivo insertion mechanism MERS-CoV Middle East Molecular biology motif Novel coronavirus outbreak phosphorylated Phosphorylation Protein protein kinases PRRA Regulatory required respiratory S1/S2 S1/S2 site S1/S2 subunits SARS-CoV2 secreted protein sequence Serine spike supported target cells the Spike viral entry [DOI] 10.1038/s41598-020-74101-0 PMC 바로가기 [Article Type] Article