Single-residue linear and conformational B cell epitopes prediction using random and ESM-2 based projectionsProblem Solving Protocol Published on 2024-03-142024-09-05 Journal: Briefings in Bioinformatics [Category] update2024, [키워드] BiLSTM embedding Epitope prediction machine learning protein structure [DOI] 10.1093/bib/bbae084 PMC 바로가기 [Article Type] Problem Solving Protocol
Site-directed neutralizing antibodies targeting structural sites on SARS-CoV-2 spike proteinArticle Published on 2024-03-142024-09-05 Journal: New biotechnology [Category] update2024, [키워드] Epivolve immunization neutralizing antibody Pan-variant antibody protein structure SARS-CoV-2 Site-directed antibody Spike protein [DOI] 10.1016/j.nbt.2023.12.004 PMC 바로가기 [Article Type] Article
AlphaFold2 Reveals Structural Patterns of Seasonal Haplotype Diversification in SARS-CoV-2 Spike Protein VariantsArticle Published on 2024-02-212024-09-05 Journal: Biology [Category] update2024, [키워드] AlphaFold COVID-19 evolutionary pressure haplotypes Mutation pandemic protein structure recruitment Spike protein variant of concern [DOI] 10.3390/biology13030134 PMC 바로가기 [Article Type] Article
Inhibition of cleavage of human complement component C5 and the R885H C5 variant by two distinct high affinity anti-C5 nanobodiesResearch Article Published on 2023-06-232024-09-05 Journal: Brain stimulation [Category] update2024, [키워드] complement system Inflammatory diseases inhibitor Innate immunity nanobody protein structure single-domain antibody (sdAb nanobody) structural model [DOI] 10.1016/j.jbc.2023.104956 PMC 바로가기 [Article Type] Research Article
Highly accurate protein structure prediction and drug screen of monkeypox virus proteomeComment Published on 2023-01-012023-06-10 Journal: The Journal of Infection [Category] Fulltext, 원숭이두창, [키워드] AlphaFold2 drug screen Monkeypox protein structure [DOI] 10.1016/j.jinf.2022.08.006 PMC 바로가기 [Article Type] Comment
Phylogenomic and Structural Analysis of the Monkeypox Virus Shows Evolution towards Increased StabilityArticle Published on 2022-12-312023-06-09 Journal: Viruses [Category] Fulltext, 원숭이두창, [키워드] high mutation Monkeypox virus mutation rate Phylogenomics protein structure [DOI] 10.3390/v15010127 PMC 바로가기
Involvement of sialoglycans in SARS-COV-2 infection: Opportunities and challenges for glyco-based inhibitorsReview Published on 2022-12-012023-07-10 Journal: Iubmb Life [Category] COVID19(2023년), [키워드] drug design glycobiology protein structure structural biology [DOI] 10.1002/iub.2692 PMC 바로가기 [Article Type] Review
Structural investigations of proteins encoded by SARS-CoV-2Article Published on 2022-09-012022-11-16 Journal: FEBS Open Bio [Category] SARS, 변종, 유전자 메커니즘, [키워드] antibodies articles bases categories cellular cleaved commenced coronavirus COVID COVID-19 pandemic cysteine proteases described ENCODE Evolution example expressed Final Genome include knowledge MN908947.3 molecular mechanism other coronaviruses pandemic polyprotein positive-sense Protein protein structure purified reported Research ribonuclease RNA genome RNAs SARS-CoV-2 selected sequenced single-stranded small molecule drugs Spike protein structural property the disease the spike protein translation Vaccines variant viral transcript were expressed [DOI] 10.1002/2211-5463.13465 PMC 바로가기
A novel structure-based approach for identification of vertebrate susceptibility to SARS-CoV-2: Implications for future surveillance programmesSARS-CoV-2에 대한 척추동물 감수성 식별을 위한 새로운 구조 기반 접근 방식: 미래 감시 프로그램에 대한 의미Article Published on 2022-09-012022-09-11 Journal: Environmental research [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] ACE2 ACE2 ortholog ACE2 orthologs acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Analysis angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 approach binding affinity conservation contribute coronavirus Critical Cross-species transmission debatable dissociation Dissociation constant domain facilitate facilitated genetic determinant genetic determinants highlight Host host cell host cell receptor host cells host range hosts in vivo Intensive interacting residue Interaction isoform Ligand mechanism molecular interaction Outbreaks Pathogens Prevent profile Protein protein structure Receptor-binding domain SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike protein Scientific community severe acute respiratory syndrome Coronavirus spike Spike protein Surveillance susceptibility susceptible the SARS-CoV-2 understanding Vertebrate Vertebrate species. viral evolution virus entry zoonotic pathogens [DOI] 10.1016/j.envres.2022.113303 PMC 바로가기 [Article Type] Article
CoVM 2: Molecular Biological Data Integration of SARS-CoV-2 Proteins in a Macro-to-Micro MethodCoVM 2: 거시적 방법에서 SARS-CoV-2 단백질의 분자 생물학적 데이터 통합Article Published on 2022-08-022022-09-11 Journal: Biomolecules [Category] SARS, 변종, 치료기술, [키워드] accumulated addition Affect analyzed association B.1.617.2 binding binding affinity binding state Biological calculated causative agent changes in collected COVID-19 COVID-19 pandemic crystal structure crystal structures Data integration Delta docking examined glycoprotein human proteins human receptor human receptors information integration Interaction lack macro molecular Molecular biology Multiple Mutation omicron physical PPI network Protein protein interaction protein structure protein structure docking protein-protein interaction public health receptor protein Research S protein S proteins SARS-CoV-2 SARS-CoV-2 protein SARS-CoV-2 proteins selected sequence strain Structure structures variant variants Viral protein Viral proteins virus–host interactions [DOI] 10.3390/biom12081067 PMC 바로가기 [Article Type] Article