proteolytic cleavage – Communicable Diseases Research

An outlook on potential protein targets of COVID-19 as a druggable site

Article

Published on 2022-11-012022-11-15
Journal: Molecular biology reports [Category] COVID19(2023년), SARS, 변종, 치료제,

The Spike-Stabilizing D614G Mutation Interacts with S1/S2 Cleavage Site Mutations To Promote the Infectious Potential of SARS-CoV-2 Variants

Article

Published on 2022-10-122022-11-16
Journal: Journal of Virology [Category] COVID19(2023년), SARS, 변종,

[키워드] acute respiratory syndrome addition association carried Cell cleavage cleavage site cleaved coronavirus D614G D614G mutation Delta dependent on epistasis epistatic interaction evaluate expressing expression increasingly Mutation omicron pandemic pathogenic Potential Protein proteolytic proteolytic cleavage pseudovirions pseudovirus pseudoviruses remained resulting S1 subunit S1/S2 S1/S2 cleavage S1/S2 cleavage site SARS-CoV-2 SARS-CoV-2 variant Site spike spike mutation spikes Spread stabilizing effect successive wave Transmissibility variant variants variants of concern Viral particles viral spike viral variant virions wild-type Wuhan
[DOI] 10.1128/jvi.01301-22 PMC 바로가기

New Perspectives on Antimicrobial Agents: Molnupiravir and Nirmatrelvir/Ritonavir for Treatment of COVID-19

항균제에 대한 새로운 관점: 코로나19 치료를 위한 몰누피라비르 및 니르마트렐비르/리토나비르

Article

Published on 2022-08-162022-09-11
Journal: Antimicrobial Agents and Chemotherapy [Category] COVID19(2023년), SARS, 변종, 치료제,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus addition adjusted relative risk antimicrobial Antiviral cause childbearing potential children Complication Contraception coronavirus disease Coronavirus-2 COVID-19 cytochrome P450 Cytochrome P450 enzymes death drug Drug administration Drug-to-drug interaction Each Emergency use authorization food hospitalizations in vitro inhibit limit management medication metabolism Mild mild to moderate moderate molnupiravir morbidity and mortality Mutation New Nirmatrelvir Nirmatrelvir/ritonavir nonspecific outcome pandemic Patient polymerase polyprotein pregnant protease proteolytic cleavage reduction Relative risk Replication Respiratory disease risk Ritonavir SARS-CoV-2 Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus-2 significantly target tested Toxicity Treatment treatment regimen U.S. Food and Drug Administration variant viral replication virus virus production
[DOI] 10.1128/aac.02404-21 PMC 바로가기 [Article Type] Article

Hemagglutinin Subtype Specificity and Mechanisms of Highly Pathogenic Avian Influenza Virus Genesis

Review

Published on 2022-07-192023-06-22
Journal: Viruses [Category] 조류인플루엔자,

[키워드] Highly pathogenic avian influenza viruses low-pathogenic avian influenza viruses multibasic cleavage site Pathogen evolution proteolytic cleavage RNA-dependent RNA polymerase virulence
[DOI] 10.3390/v14071566 PMC 바로가기 [Article Type] Review

COVID-19 and Liquid Homeostasis in the Lung-A Perspective through the Epithelial Sodium Channel (ENaC) Lens

Review

Published on 2022-05-312023-07-09
Journal: Cells [Category] COVID19(2023년),

[키워드] airway liquid alveolar liquid COVID-19 epithelial Na+ channel Proteases proteolytic cleavage SARS-CoV-2 transepithelial ion transport.
[DOI] 10.3390/cells11111801 PMC 바로가기 [Article Type] Review

Molecular docking analysis reveals the functional inhibitory effect of Genistein and Quercetin on TMPRSS2: SARS-COV-2 cell entry facilitator spike protein

분자 도킹 분석을 통해 TMPRSS2: SARS-COV-2 세포 진입 촉진제 스파이크 단백질에 대한 제니스테인 및 퀘르세틴의 기능적 억제 효과가 나타남

Article

Published on 2022-05-162022-09-11
Journal: BMC Bioinformatics [Category] COVID19(2023년), SARS, 치료제,

[키워드] active site Analysis Anti-viral binding binding affinity binding free energy binding pocket Bioinformatics tools catalytic catalytic site cell entry Combination complex Compound compounds conformational coronavirus spike protein Critical docked docking docking analysis dynamic Efficacy exhibit form free energy functional Genistein host cell human cell hydrogen Hydrogen bond hydrophilic hydrophobic identify Infection inhibit inhibitory effect Innate immunity Interaction Medicines molecular docking molecular docking analysis molecular dynamic simulations molecular dynamics Molecular dynamics simulation performed Phyto compounds Prevent priming Protein proteolytic cleavage quercetin receptor ACE2 reduce residue reveal SARS-CoV-2 coronavirus SARS-COV-2 infection Schrodinger screened selected Serine serine protease Simulation Spike protein stable complex subsequent target target protein the spike protein therapeutic target TMPRSS TMPRSS2 transmembrane glycoprotein transmembrane serine protease transmembrane serine protease 2 type I type I transmembrane glycoprotein Vaccine virus weak interaction
[DOI] 10.1186/s12859-022-04724-9 PMC 바로가기 [Article Type] Article

Role of Tocilizumab in Down Regulating sCD163 Plasmatic Levels in a Cohort of COVID-19 Patients

COVID-19 환자 집단에서 sCD163 혈장 수준을 하향 조절하는 토실리주맙의 역할

Article

Published on 2022-04-042022-09-12
Journal: Frontiers in Immunology [Category] 진단,

[키워드] anti-IL-6 receptor Biomarker both group CD163 Cell Clinical outcome clinical utility Cohort comparable control group COVID-19 COVID-19 patient COVID-19 patients defined died discharge down-regulated early stage ELISA enrolled evaluated expressed Follow-up group groups healthy donor Hospital admission Hospitalization IL-6 Inflammatory involved Laboratory parameters lethality rate Level Lineage macrophages mechanical ventilation monoclonal antibody monocyte monocytes/macrophages outcome plasma Pneumonia pro-inflammatory proteolytic cleavage receptor reduce reduction in reductions in Regulating Regulation required role SARS-CoV-2 sCD163 severity of COVID-19 statistically stratified TCZ the disease Tocilizumab Treatment
[DOI] 10.3389/fimmu.2022.871592 PMC 바로가기 [Article Type] Article

Capturing a Crucial ‘Disorder-to-Order Transition’ at the Heart of the Coronavirus Molecular Pathology—Triggered by Highly Persistent, Interchangeable Salt-Bridges

Article

Published on 2022-02-162022-10-28
Journal: Vaccines [Category] COVID-19,

[키워드] anionic appear arginine baseline being binding catalytic cationic characteristic cleavage site coronavirus COVID-19 disorder disorder-to-order transition enthalpy entropy compensation entropy arrest events Evolution feature FLCS flexible furin cleavage Genome heart homologous Host increase in Interaction interactions Lineage Molecular pathology motif multiplicity offer persistent polybasic Protein proteolytic proteolytic cleavage residue respiratory viral diseases respiratory viruses S1/S2 junction salt-bridge salt-bridge dynamics SARS-CoV SARS-CoV-2 spike Spike–Furin interaction the SARS-CoV-2 Transmissibility
[DOI] 10.3390/vaccines10020301 PMC 바로가기 [Article Type] Article

In Silico Molecular Characterization of Human TMPRSS2 Protease Polymorphic Variants and Associated SARS-CoV-2 Susceptibility

Article

Published on 2022-02-032022-10-29
Journal: International Review of Cell and Molecular Biology [Category] COVID-19,

[키워드] 2019 coronavirus disease acute respiratory syndrome addition Alter Analysis analyzed Camostat mesylate cell entry characterization complex coronavirus COVID-19 develop docking drug examined global pandemic glycoprotein Health care system high affinity host susceptibility Human Infection inhibitors Interaction interactions intermolecular interaction investigated molecular molecular docking nafamostat pandemic Polymorphic Polymorphisms predicted protease inhibitors Protective proteolytic cleavage reported responsible S glycoprotein SARS-CoV-2 SARS-CoV-2 spike serine protease serine protease inhibitors Spike protein Spread Structural analysis susceptibility the SARS-CoV-2 TMPRSS2 transmembrane serine protease treating COVID-19 patients Type variant variants Variation
[DOI] 10.3390/life12020231 PMC 바로가기 [Article Type] Article

Cryptococcal Protease(s) and the Activation of SARS-CoV-2 Spike (S) Protein

Article

Published on 2022-01-272022-10-31
Journal: Cells [Category] COVID-19,