A Universal DNA Aptamer that Recognizes Spike Proteins of Diverse SARS-CoV-2 Variants of Concern다양한 SARS-CoV-2 변이체의 스파이크 단백질을 인식하는 범용 DNA 앱타머Article Published on 2022-03-102022-09-11 Journal: Chemistry (Weinheim an Der Bergstrasse, Germany) [Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료기술, 치료제, [키워드] Alpha Analysis aptamer Beta carried Complexes complexes concern COVID-19 Delta diagnostics DNA eight Epsilon Evidence experiment experiments expressing FIVE followed by Gamma high affinity High-throughput sequencing molecular omicron Omicron variants produced Protein Proteins provide pseudotyped lentivirus pseudotyped lentiviruses S1 domain SARS-CoV-2 sequence Sequence alignment Sequencing spike Spike protein Spike proteins target the spike protein Trimeric spike protein unique Universal variant variant spike variants variants of concern variants of concern. wildtype [DOI] 10.1002/chem.202200078 PMC 바로가기 [Article Type] Article
Mutants of human ACE2 differentially promote SARS-CoV and SARS-CoV-2 spike mediated infection인간 ACE2의 돌연변이는 SARS-CoV 및 SARS-CoV-2 스파이크 매개 감염을 차등적으로 촉진합니다Research Article Published on 2021-07-162022-09-10 Journal: PLoS Pathogens [Category] SARS, 변종, [키워드] abrogated abundance ACE2 ACE2 protein ACE2 sequence Affect allele bind binding biochemical Cell cell line cell surface cells change coding coronavirus coronavirus spike proteins correlated CoV spike proteins Cross-species transmission Cytopathic effect cytopathic effects determine Effect Efficiency engage events exomes expressed expression fraction Genetic genomic integration HEK 293T Human human ACE2 human Ace2 protein implication infect cells Infection inhibited Interaction Missense missense mutants Modification mutant mutants N501Y Non-linear relationship nucleotide overlapping parental promote Protein pseudotyped lentivirus pseudovirus entry pseudovirus infection Quantitative receptor protein reduced reducing reference sequence SARS-CoV SARS-CoV entry SARS-CoV-2 SARS-CoV-2 RBD binding SARS-CoV-2 replication SARS-CoV-2 spike SARS-CoV-2 spike proteins SARS-CoV-2 spike variants SARS-like coronavirus SARS-like coronaviruses sequence single nucleotide Spike protein Spike proteins susceptibility susceptibility to infection target cell target cells the cell the spike protein transgenic unique variant variants Viral viral spike virus virus viruses while zoonotic [DOI] 10.1371/journal.ppat.1009715 PMC 바로가기 [Article Type] Research Article