Pulmonary edema – Communicable Diseases Research

Proteomic analysis and identification reveal the anti-inflammatory mechanism of clofazimine on lipopolysaccharide-induced acute lung injury in mice

Article

Published on 2022-11-012022-11-15
Journal: Inflammation research : official journal of the Eu [Category] 유전자 메커니즘, 진단,

Fatal Form of COVID-19 in a Young Male Bodybuilder Anabolic Steroid Using: The First Autopsied Case

Article

Published on 2022-09-292022-11-15
Journal: Medicina [Category] SARS, 진단,

Assessment of Tocilizumab (Humanized Monoclonal Antibody) for Therapeutic Efficacy and Clinical Safety in Patients with Coronavirus Disease (COVID-19)

코로나바이러스 감염증(COVID-19) 환자의 치료 효능 및 임상 안전성에 대한 토실리주맙(인간화 단클론항체) 평가

Article

Published on 2022-08-102022-09-12
Journal: Medicina [Category] SARS, 진단,

[키워드] activated acute respiratory distress added adverse effect airways alanine aminotransferase alkaline phosphatase ALP ALT analysis Anticoagulant ARDS assessment Autoimmune Bacterial baseline C-reactive protein characterized clinical coagulation parameter Coagulopathy control group COVID-19 COVID-19 cases COVID-19 patient COVID-19 patients CRP CRS Cytokine release syndrome Cytokine storm D-dimer discharged Efficacy Endpoint expired fatality ferritin Follow-up humanized monoclonal antibody include infection rate Inflammatory inflammatory conditions inflammatory parameter inflammatory parameters INR institution institutional protocol International lactate dehydrogenase LDH Manifestations material normalized patients of COVID-19 Platelet Pneumonia presenting Prothrombin time provided Pulmonary edema raised receiving respiratory tract infection Result Safety severe COVID-19 patients severe disease significantly higher statistically significant difference survival rate syndrome Teaching the disease the patient therapeutic efficacy Tocilizumab tocilizumab. treat Treatment Treatment protocol treatment regimen was performed
[DOI] 10.3390/medicina58081076 PMC 바로가기 [Article Type] Article

Comprehensive overview of COVID-19-related respiratory failure: focus on cellular interactions

Review

Published on 2022-07-302023-07-10
Journal: Cellular & Molecular Biology Letters [Category] COVID19(2023년),

[키워드] airway epithelial cells COVID-19 Cytokines endothelial cells Platelets Pulmonary edema SARS-CoV-2.
[DOI] 10.1186/s11658-022-00363-3 PMC 바로가기 [Article Type] Review

Actions of Novel Angiotensin Receptor Blocking Drugs, Bisartans, Relevant for COVID-19 Therapy: Biased Agonism at Angiotensin Receptors and the Beneficial Effects of Neprilysin in the Renin Angiotensin System

새로운 안지오텐신 수용체 차단 약물, 비사르탄, COVID-19 치료와 관련된 작용: 안지오텐신 수용체의 편향 작용 및 레닌 안지오텐신 시스템에서 네프릴리신의 유익한 효과

Article

Published on 2022-07-292022-09-11
Journal: Molecules [Category] COVID19(2023년), SARS, 바이오마커,

[키워드] 3CLpro ACE2 Action activated activating active site Agonism ANG Ang II angiotensin angiotensin converting enzyme Angiotensin II angiotensin II receptor blockers (ARBS) angiotensin II receptors Angiotensin receptor blockers anionic ARB/NEP docking ARBs AT1 AT2 biased agonism binding biphenyl bisartans blocker blocking cells charge relay system (CRS) complementary COVID-19 COVID-19 virus DNA driven by edema Effect endopeptidase enzyme Evidence explained furin G protein Human genome humoral hypertension in silico inhibit inhibiting inverse agonist involved modulating molecular molecular dynamics Molecular dynamics (MD) mRNA neprilysin novel opposite peptide peptides Protein Pulmonary edema RAS receptor Receptor Blockers receptors Renin SARS-COV-2 infection Sartans. Screening Serine serine proteases switching System tetrazole this system Treatment Vasoactive viral entry Zinc
[DOI] 10.3390/molecules27154854 PMC 바로가기 [Article Type] Article

Adverse perinatal outcomes in a large United States birth cohort during the COVID-19 pandemic

Observational Study

Published on 2022-05-012022-10-05
Journal: American journal of obstetrics & gynecology MFM [Category] 임상,

[키워드] 95% confidence interval adjusted adjusted odds ratio Adverse adverse outcome adverse perinatal outcomes age association Cohort Combined confidence interval coronavirus disease COVID-19 COVID-19 pandemic dataset death diagnosed with COVID-19 Diagnosis Disseminated intravascular coagulopathy examined high-risk pregnancy. highest Hospitalization Hospitalized in-hospital mortality Logistic regression mechanical ventilation Mortality National no difference no significant difference Observational cohort study Odds ratio outcome pandemic patients placental Pregnancy Preterm birth Prevalence Pulmonary edema raising risk significantly higher Stillbirth United State with COVID-19 women
[DOI] 10.1016/j.ajogmf.2022.100577 PMC 바로가기 [Article Type] Observational Study

Safety and preliminary efficacy of sequential multiple ascending doses of solnatide to treat pulmonary permeability edema in patients with moderate to severe ARDS in a randomized, placebo-controlled, double-blind trial: preliminary evaluation of safety and feasibility in light of the COVID-19 pandemic

Randomized Controlled Trial

Published on 2022-04-042022-10-05
Journal: Trials [Category] COVID19(2023년), SARS, 임상,

[키워드] activity Alter ARDS ARDS patient Ascending baseline causes Clinical characteristics clinical study clinical trial conducted COVID-19 COVID-19 ARDS patient COVID-19 pandemic COVID-19 patient doses double-blind DSMB edema Efficacy enrolled Enrollment Evidence exceptional feasibility groups indication interim analysis investigator less mandatory Multiple multiple ascending dose noradrenaline not differ observation period outcome Oxygenation pandemic parameter Patient patients with moderate permeability phase IIB placebo-controlled pulmonary Pulmonary edema pulmonary permeability Randomized required risk Safety Safety Monitoring Board SARS-CoV-2 Sepsis severe ARDS sick Solnatide Study design survival rate treat Trial Ventilation
[DOI] 10.1186/s13063-022-06182-3 PMC 바로가기 [Article Type] Randomized Controlled Trial

The INVENT COVID trial: a structured protocol for a randomized controlled trial investigating the efficacy and safety of intravenous imatinib mesylate (Impentri®) in subjects with acute respiratory distress syndrome induced by COVID-19

INVENT COVID 시험: COVID-19에 의해 유발된 급성 호흡곤란 증후군이 있는 피험자를 대상으로 정맥 이마티닙 메실레이트(Impentri®)의 효능과 안전성을 조사하는 무작위 대조 시험을 위한 구조화된 프로토콜

Study Protocol

Published on 2022-02-162022-09-10
Journal: Trials [Category] COVID19(2023년), MERS, SARS, 임상,

[키워드] 1:1 28-day mortality acute respiratory distress acute respiratory distress syndrome Admission ARDS Berlin criteria bis in die Chain Reaction changes in characterized clinical trial coronavirus disease Coronavirus disease 2019 COVID COVID-19 death decrease demonstrated discharge disease severity double-blind edema Efficacy and safety endothelial Endothelial dysfunction Estimated Extravascular lung water hypoxemic Hypoxemic respiratory failure ICU Imatinib imatinib mesylate immune response include increase in index Inflammation inflammatory conditions inhibitor intensive care intensive care unit intravenous Invasive mechanical ventilation IV infusion Kinase inhibitor life-threatening lung Lungs mechanical ventilation mechanically ventilated mesylate moderate-severe Mortality multicenter Older outcome Oxygenation pandemic parallel-group parameter parameters participant pharmacokinetics Placebo placebo-controlled polymerase chain polymerase chain reaction positive Prevent protocol Pulmonary edema randomization Randomized Randomized controlled trial recruitment reduce reduction in reflected respiratory distress Respiratory failure SARS-CoV2 secondary study period subject syndrome therapy Tolerability Trial registration tyrosine tyrosine kinase inhibitor Vascular vascular permeability Ventilation ventilator-free day Ventilator-free days water widespread
[DOI] 10.1186/s13063-022-06055-9 PMC 바로가기 [Article Type] Study Protocol

Development of computer-aided model to differentiate COVID-19 from pulmonary edema in lung CT scan: EDECOVID-net

폐 CT 스캔에서 코로나19와 폐부종을 구별하는 컴퓨터 지원 모델 개발: EDECOVID-net

Article

Published on 2022-02-012022-09-11
Journal: Computers in biology and medicine [Category] COVID19(2023년), SARS, 치료기술,

[키워드] Accuracy acetazolamide addition Administered Algorithm automatically benefit breathing carbon dioxide Computer-aided detection system (CADs) Consequences COVID-19 COVID-19 patient COVID-19 patients COVID-19 symptom COVID-19 symptoms CT images detection system development diagnosing early stages edema effort Features Hypotension knowledge Lung CT lung CT scan Lung CT scans machine machine learning matching mathematical Patient Perfusion Prevent pulmonary Pulmonary edema Pulmonary edema. risk spread of COVID-19 systemic hypotension systemically the patient Transport treat Ventilation with COVID-19 Work of breathing worsening
[DOI] 10.1016/j.compbiomed.2021.105172 PMC 바로가기 [Article Type] Article

Acyl-Coenzyme A Synthetase Long-Chain Family Member 4 Is Involved in Viral Replication Organelle Formation and Facilitates Virus Replication via Ferroptosis

Research Article

Published on 2022-01-182022-10-29
Journal: mBio [Category] COVID-19, COVID19(2023년), MERS, SARS,