Purifying selection leads to low protein diversity of the mitochondrial cyt b gene in avian malaria parasites정화 선택은 조류 말라리아 기생충의 미토콘드리아 cyt b 유전자의 낮은 단백질 다양성으로 이어진다.Article Published on 2023-09-112024-08-26 Journal: BMC Ecology and Evolution [Category] 말라리아, [키워드] Avian malaria cytochrome b host specificity purifying selection [DOI] 10.1186/s12862-023-02155-5 PMC 바로가기
Genetic Surveillance of SARS-CoV-2 Mpro Reveals High Sequence and Structural Conservation Prior to the Introduction of Protease Inhibitor PaxlovidArticle Published on 2022-08-302022-11-15 Journal: mBio [Category] COVID19(2023년), SARS, 변종, 치료제, [키워드] 3CLpro acute respiratory syndrome Analysis analyzed Antiviral antiviral drug Antiviral treatment antivirals baseline binding circulating cleavage clinical response conservation conserved Contact Coronaviral Coronaviridae family coronavirus COVID-19 COVID-19 pandemic Critical database determine drug target effort Emergency use authorization enzyme escape mutation EUA Evolution expected Genetic genomic GISAID globe health emergency implication inhibitor inhibitors initiative introduced isolate isolates M pro motifs MPro Mutation Nirmatrelvir pandemic progresse Paxlovid protease purifying selection raise reference sequence Region remained residue retrieved robust SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 Mpro SARS-CoV-2 viral selective sequence Sequencing starting point Surveillance the SARS-CoV-2 the spike protein Treatment unique variants variants of SARS-CoV-2 virus widespread Wuhan-Hu-1 [DOI] 10.1128/mbio.00869-22 PMC 바로가기
Purifying Selection Determines the Short-Term Time Dependency of Evolutionary Rates in SARS-CoV-2 and pH1N1 InfluenzaDiscoveries Published on 2022-02-172022-10-29 Journal: Molecular Biology and Evolution [Category] COVID-19, COVID19(2023년), MERS, SARS, 신종인플루엔자, [키워드] Accuracy Affect Analysis Bayesian both viruses clock rate correlated Course dependency elevated estimates evolutionary dynamics Evolutionary rate Genome sequencing growth growth rate H1N1 High-throughput sequencing infectious disease outbreak Influenza Logistic molecular molecular clock observation pandemic Pandemics parameter parameters pathogen Phylogenetic provide Purifying purifying selection Rate SARS-CoV-2 Selection sequence substitution rate the mean time time dependency timespan [DOI] 10.1093/molbev/msac009 PMC 바로가기 [Article Type] Discoveries
Causes and Consequences of Purifying Selection on SARS-CoV-2SARS-CoV-2에 대한 정제 선택의 원인과 결과Research Article Published on 2021-10-242022-09-10 Journal: Genome Biology and Evolution [Category] MERS, SARS, 변종, [키워드] Amino acid amino acids Analysis appearance cause classical codon usage complex consequence degenerate Deleterious disparate disrupt Evidence Evolution genomes humans implication Ka/K less lineages majority Missense Mutation mutation rate mutations nonsense mutation Nonsense mutations offspring parameters parent parents predicted Protein purging Purifying purifying selection SARS-CoV-2 Selection selective SNP synonymous Vaccine variant variants [DOI] 10.1093/gbe/evab196 PMC 바로가기 [Article Type] Research Article
SARS‐CoV‐2, an evolutionary perspective of interaction with human ACE2 reveals undiscovered amino acids necessary for complex stabilityOriginal Article Published on 2020-05-072022-10-31 Journal: Evolutionary Applications [Category] COVID-19, [키워드] ACE2 Amino acid Analysis Betacoronavirus betacoronavirus spike protein binding cell receptor complex conserved coronavirus Critical death determine directional effective ENhance evolutionary dynamics Factor FIVE genomic region glycine hACE2 host cells human ACE2 human cell human cells human host implicated IMPROVE infect Infection infections inhibiting binding Interaction modeling molecular dynamics performed Perspective Positive selection predict purifying selection receptor receptor ACE2 receptor‐binding domain residue reveal Salt Bridge SARS‐CoV‐2 SARS‐CoV‐2 selection pressure spike glycoprotein Spike protein stability viral evolution viral lineages viral spike protein virus [DOI] 10.1111/eva.12980 PMC 바로가기 [Article Type] Original Article
Comparative Analyses of Selection Operating on Nontranslated Intergenic Regions of Diverse Bacterial Speciesarticle Published on 2017-05-312024-09-01 Journal: Environmental Science & Policy [Category] 폐렴구균 감염증, [키워드] Bacterial genomics intergenic regions (IGRs) purifying selection whole-genome sequencing [Article Type] article