Selection of Bis-Indolyl Pyridines and Triphenylamines as New Inhibitors of SARS-CoV-2 Cellular Entry by Modulating the Spike Protein/ACE2 Interfaces스파이크 단백질/ACE2 인터페이스를 조절하여 SARS-CoV-2 세포 진입의 새로운 억제제로서 비스-인돌릴 피리딘 및 트리페닐아민 선택Article Published on 2022-08-162022-09-11 Journal: Antimicrobial Agents and Chemotherapy [Category] COVID19(2023년), SARS, 변종, [키워드] 50% effective concentration ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus approaches association biochemical caused Cell cell lines cellular cellular receptor circulating circulating variant complex Compound coronavirus coronavirus disease COVID COVID-19 docking drug functional human cell lines identify in silico indicate Infection infectious agent inhibit inhibitor inhibitory inhibitory effect Interaction interface Lentiviral vector lentiviral vectors modulating molecular molecules New pandemic parameter pseudotyped pyridine receptor ACE2 S protein SARS-CoV-2 SARS-CoV-2 entry SARS-CoV-2 S protein SARS-CoV-2 strain screened selected Selection severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 spike susceptible the SARS-CoV-2 the Spike therapeutic purposes these compound these compounds triphenylamine variant viral entry viral infection viral replication virus wild-type [DOI] 10.1128/aac.00083-22 PMC 바로가기 [Article Type] Article
Pyridine Compounds with Antimicrobial and Antiviral Activities항균 및 항바이러스 활성을 갖는 피리딘 화합물Review Published on 2022-05-182022-09-11 Journal: International Journal of Molecular Sciences [Category] COVID19(2023년), SARS, 치료제, [키워드] activity analgesic Anti-inflammatory anticonvulsant antidiabetic antimicrobial antioxidant Antiviral antiviral activities binding caused Compound compounds correlation COVID-19 pandemic determine group groups heterocyclic compounds hydrocarbon IMPROVE Interaction life-threatening linker molecular docking studies molecules nucleus priority Protein pyridine Research SARS-CoV-2 virus singular specific protein synthesis the SARS-CoV-2 virus therapeutic water [DOI] 10.3390/ijms23105659 PMC 바로가기 [Article Type] Review